Johan Van Eerden

Intraannular functionalization of macrocyclic polyethers via organolithium chemistry; x-ray structure of 2-sulfinyl-1,3-xylyl-15-crown-4

The conversion of 2-lithio-1,3-xylyl crown ethers (2), obtained by reaction of the 2-bromo-1,3-xylyl crown ethers (1) with n_-butyllithium at −70 °C, with an electrophile is a generally applicable method for the synthesis of 1,3-xylyl crown ethers with intraannular acidic groups.

Synthesis, complexation, and X-ray structure of a new type of binucleating macrocycle incorporating both soft and hard ligating sites

A macrocyclic ligand with both a Schiff base moiety and a polyether cavity forms mono- and bi-nuclear complexes; X-ray analysis of the mononuclear Ba(ClO4)2 complex shows that Ba2+ is co-ordinated in the polyether cavity.