Johannes Hensel

Infrasonic and low-frequency insert earphone hearing threshold

Low-frequency and infrasonic pure-tone monaural hearing threshold data down to 2.5 Hz are presented. These measurements were made by means of a newly developed insert-earphone source. The source is able to generate pure-tone sound pressure levels up to 130 dB between 2 and 250 Hz with very low harmonic distortions. Behavioral hearing thresholds were determined in the frequency range from 2.5 to 125 Hz for 18 otologically normal test persons. The median hearing thresholds are comparable to values given in the literature. They are intended for stimulus calibration in subsequent brain imaging investigations.

A simple electrical lumped-element model simulates intra-cochlear sound pressures and cochlear impedance below 2 kHz

Low-frequency sounds displace large parts of the basilar membrane (BM) and can have a modulating and possibly disturbing effect on hearing at other frequencies. A better understanding of the transfer of such sounds onto the BM is therefore desirable. Lumped-element models have previously been employed to determine the low-frequency acoustic properties of the cochlea. Although helpful in illustrating schematically the role of the helicotrema, BM compliance, and the round window on low-frequency hearing, these models, when applied quantitatively, have not been able to explain experimental data in detail. Building on these models, an extended electrical analog requires just 13 lumped elements to capture, in surprising detail, the physiologically determined frequency-dependence of intra-cochlear pressure and cochlear impedance between 10 Hz and 2 kHz. The models verification is based on data from cat, guinea pig, and humans, who differ principally in their low-frequency cochlear acoustics. The modeling data suggest that damping within the helicotrema plays a less prominent role than previously assumed. A resonance feature, which is often observed experimentally near 150 Hz in these animals and near 50 Hz in humans, is presumably a phenomenon local to the apex and not the result of a standing wave between stapes and helicotrema.

Altered cortical and subcortical connectivity due to infrasound administered near the hearing threshold – Evidence from fMRI

In the present study, the brain’s response towards near- and supra-threshold infrasound (IS) stimulation (sound frequency < 20 Hz) was investigated under resting-state fMRI conditions. The study involved two consecutive sessions. In the first session, 14 healthy participants underwent a hearing threshold—as well as a categorical loudness scaling measurement in which the individual loudness perception for IS was assessed across different sound pressure levels (SPL). In the second session, these participants underwent three resting-state acquisitions, one without auditory stimulation (no-tone), one with a monaurally presented 12-Hz IS tone (near-threshold) and one with a similar tone above the individual hearing threshold corresponding to a ‘medium loud’ hearing sensation (supra-threshold). Data analysis mainly focused on local connectivity measures by means of regional homogeneity (ReHo), but also involved independent component analysis (ICA) to investigate inter-regional connectivity. ReHo analysis revealed significantly higher local connectivity in right superior temporal gyrus (STG) adjacent to primary auditory cortex, in anterior cingulate cortex (ACC) and, when allowing smaller cluster sizes, also in the right amygdala (rAmyg) during the near-threshold, compared to both the supra-threshold and the no-tone condition. Additional independent component analysis (ICA) revealed large-scale changes of functional connectivity, reflected in a stronger activation of the right amygdala (rAmyg) in the opposite contrast (no-tone > near-threshold) as well as the right superior frontal gyrus (rSFG) during the near-threshold condition. In summary, this study is the first to demonstrate that infrasound near the hearing threshold may induce changes of neural activity across several brain regions, some of which are known to be involved in auditory processing, while others are regarded as keyplayers in emotional and autonomic control. These findings thus allow us to speculate on how continuous exposure to (sub-)liminal IS could exert a pathogenic influence on the organism, yet further (especially longitudinal) studies are required in order to substantialize these findings.

Equivalent hearing threshold levels for the Etymotic Research ER-10C otoacoustic emission probe

Objective: To determine the equivalent threshold sound pressure levels (ETSPL) for a commercially available distortion product otoacoustic emission (DPOAE) probe, and to study the impact of probe fitting and eartip size on the calibration. Design: Twenty-eight otologically normal test subjects participated in the ETSPL determination for the Etymotic Research ER-10C probe. Study sample: ETSPLs were determined up to 16 kHz and were compared to the reference hearing thresholds associated with the ER-3A insert earphone. Both ‘regular’ and ‘baby’ foam eartips were used. Results: At most frequencies, no significant threshold differences were observed between the insert earphone and the DPOAE probe. However, at 1 kHz and 4 kHz, the mean thresholds for the insert earphone were generally lower than those for the DPOAE probe, suggesting systematic differences at those frequencies. Repeated calibration runs resulted in deviations of about 0.6 dB. Similar deviations were noticed when using foam eartips of different sizes up to 10 kHz. Conclusions: Knowing the reference thresholds for DPOAE probes enables measurements of (subjective) hearing thresholds and (objective) otoacoustic emissions using the same probe. Probe fitting and eartip size had negligible effect on the determination of ETSPLs. The obtained data may be proposed for inclusion in future audiometry standards.

Evaluation of cost-efficient auditory MEG stimulation

An acoustic source based on a piezoelectric transducer and commonly available parts was designed to measure auditory evoked MEG. Its magnetic and acoustic properties were tested and MEG measurements were made. The obtained datasets were analyzed and the auditory event related fields were calculated using free software package FieldTrip (www.fieldtriptoolbox.org). The setup successfully delivers sounds at frequencies of interest from 1 kHz to 8 kHz and it is suitable for auditory evoked MEG measurements as data recorded with the MEG showed the auditory M100 response.

Distortion product otoacoustic emissions upon ear canal pressurization

The purpose of this study was to quantify the change in distortion product otoacoustic emission (DPOAE) level upon ear canal pressurization. DPOAEs were measured on 12 normal-hearing human subjects for ear canal static pressures between -200 and +200 daPa in (50 ± 5) daPa steps. A clear dependence of DPOAE levels on the pressure was observed, with levels being highest at the maximum compliance of the middle ear, and decreasing on average by 2.3 dB per 50 daPa for lower and higher pressures. Ear canal pressurization can serve as a tool for improving the detectability of DPOAEs in the case of middle-ear dysfunction.