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Dive into the research topics where John A. Kepler is active.

Publication


Featured researches published by John A. Kepler.


Biochemistry | 1995

THE SPONGISTATINS, POTENTLY CYTOTOXIC INHIBITORS OF TUBULIN POLYMERIZATION, BIND IN A DISTINCT REGION OF THE VINCA DOMAIN

Ruoli Bai; George F. Taylor; Zbigniew A. Cichacz; Cherry L. Herald; John A. Kepler; George R. Pettit; Ernest Hamel


Journal of Pharmacology and Experimental Therapeutics | 1976

Caffeine in plasma and saliva by a radioimmunoassay procedure.

Clarence Cook; Clyde Tallent; Ew Amerson; Mary Myers; John A. Kepler; George F. Taylor; Hd Christensen


Cancer Research | 1996

Characterization of the interaction of cryptophycin 1 with tubulin : Binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction

Ruoli Bai; Robert E. Schwartz; John A. Kepler; George R. Pettit; Ernest Hamel


Archive | 1999

20-keto-11 beta -arylsteroids and their derivatives having agonist or antagonist hormonal properties

C. Edgar Cook; John A. Kepler; Ping-Sheng Zhang; Yue-Wei Lee; C. Ray Tallent


Molecular Pharmacology | 2000

Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity

Pascal Verdier-Pinard; John A. Kepler; George R. Pettit; Ernest Hamel


Journal of Biological Chemistry | 2004

Direct Photoaffinity Labeling by Dolastatin 10 of the Amino-terminal Peptide of β-Tubulin Containing Cysteine 12

Ruoli Bai; David G. Covell; George F. Taylor; John A. Kepler; Terry D. Copeland; Nga Nguyen; George R. Pettit; Ernest Hamel


Archive | 1999

17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties

C. Edgar Cook; John A. Kepler; Rupa S. Shetty; Gary S. Bartley; David Yue-Wei Lee


Organic Letters | 2001

Effect of a 17α-(3-Hydroxypropyl)-17β-acetyl Substituent Pattern on the Glucocorticoid and Progestin Receptor Binding of 11β-Arylestra-4,9-dien-3-ones

Clarence Cook; Prasad Raje; Dyw Lee; John A. Kepler


Archive | 1999

17.beta.-acyl-17.alpha.-propynyl-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties:

Clarence Cook; John A. Kepler; Jill M. O'reilly


Journal of Organic Chemistry | 1987

An unequivocal synthesis of (methylazoxy)methanol acetate and ([14C]methylazoxy)methanol acetate

John A. Kepler; George F. Taylor

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Yue-Wei Lee

Research Triangle Park

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Ernest Hamel

National Institutes of Health

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