John B. Field

Effect of Heparin and Treburon in Postprandial Hyperlipemia

Conclusions 1. Heparin or Treburon given intramuscularly were equally effective in producing a sharp fall in alimentary lipomicronemia within 30 to 60 minutes. 2. The alterations noted in serum fat emulsions were not related to changes in cholesterol, its fractions, or lipid phosphorus. These chemical determinations were not significantly influenced by either heparin or Treburon. 3. Treburon given intravenously produced a sharp drop in the lipid particle count within 5 to 15 minutes and this was maximal within one hour of injection. 4. Treburon given sublingually was ineffective.

Reversal of Nitrogen Mustard Intoxication by a Serotonin Antagonist.

Summary The intraperitoneal administration of a pyrazolone compound before and after a single intraperitoneal nearly-lethal dose of nitrogen mustard had been given to mice produced a marked reduction of the mortality expected from the nitrogen mustard. Furthermore the leukopenia resulting from the nitrogen mustard was considerably less in extent and duration.

Qualitative Colorimetric Assay of Tyrosinase Substrates and Inhibitors.

Summary 1. A qualitative in vitro colorimetric assay for potato tyrosinase substrates and inhibitors is described. 2. L-tyrosine, tyrosine ethyl ester, and chloracetyl-L-tyro-sine were found to be suitable substrates, and the latter 2 compounds were attacked more rapidly than tyrosine itself. 3. These findings are in agreement with reported manometric studies on the specificity and velocity of plant tyrosinase. 4. The potato tyrosinase system was compared with one employing the enzyme from the Harding-Passey mouse melanoma.

Increased Growth Produced by Gelatin in Trout Fed Meatless Diets.

Summary It has been shown that growing trout require a diet containing fresh meat. Mixed diets devoid of fresh meat did not produce any increase in the growth of trout, Varying the nature of the dried liver fractions used did not stimulate growth. When these diets were enclosed in gelatin capsules and force fed to the fish, a marked gain in weight was obtained. Supplementing the meatless diets with gelatin resulted in satisfactory initial growth. The supplemented diets did not sustain continuing growth beyond 7 weeks suggesting that further deficiencies exist in these rations.