Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where John D. Higgins is active.

Publication


Featured researches published by John D. Higgins.


Drug Development and Industrial Pharmacy | 2002

Evaluation of the film-coating properties of a hydroxyethyl cellulose/hydroxypropyl methylcellulose polymer system.

Shun Por Li; Stephen A. Martellucci; Adam C. Kinyon; Michael B. Hay; John D. Higgins

ABSTRACT The effect of different grades of hydroxyethyl cellulose (HEC) and hydroxypropyl methylcellulose (HPMC) on the film-formation and taste-masking ability for ibuprofen granules was evaluated. Three batches of coated ibuprofen granules were prepared using a roto-granulator, each with a different coating composition. Two grades of HEC [MW 300,000 (H) and MW 90,000 (L)] were combined with three different grades of HPMC [MW 11,000 (L), MW 25,000 (M) and MW 35,000 (H)] to prepare the coating solutions. Mechanical strength and physical properties of the polymer films were evaluated. Films made from HPMC (L)/HEC (H), HPMC (M)/HEC (H), and HPMC (H)/HEC (H) were stronger and more flexible than the HPMC (L)/HEC (L) films. The assay, dissolution, particle size distribution, and environmental scanning electron microscopy (ESEM) data of the three batches of the coated ibuprofen granules were similar. These data indicated that the two grades of HEC had equivalent film-coating properties. However, the HPMC (L)/HEC (L) film-coated granules showed better taste-masking characteristics (no burning after-taste) than the HPMC (L)/HEC (H) and HPMC (M)/HEC (H) film-coated granules. The ESEM data of the polymer films indicated that both HPMC (L)/HEC (H) and HPMC (M)/HEC (H) films exhibited more roughness and contained larger particles than the HPMC (L)/HEC (L) films. A hydration/dehydration study of the films revealed that HPMC (L)/HEC (H) and HPMC (M)/HEC (H) films were more susceptible to moisture effects, which subsequently led to a faster hydration rate of the polymer films. These data suggest that the molecular weight of the HEC affects the taste-masking ability of the resultant polymer film. The HEC (L) mixed well with the HPMC (L) to yield a uniform film that was more resistant to moisture effects. Hence, for optimum coating applications, particular attention should be paid to the molecular weight of the coating polymers to ensure that they are comparable to each other.


Archive | 1998

Method for producing water dispersible sterol formulations

Brid Burruano; Michael R Hoy; John D. Higgins


Archive | 1998

Alkali metal and alkaline-earth metal salts of acetaminophen

Lena A. Ohannesian; David Nadig; John D. Higgins; Max Rey; Stephen A. Martellucci


Archive | 1999

Stable salad dressings

Clemence K. Dartey; John D. Higgins; Brid Burruano


Archive | 1999

Sterol esters in tableted solid dosage forms

John D. Higgins; Stephen A. Martellucci


Archive | 1999

Pharmaceutical composition containing a salt of acetaminophen and at least one other active ingredient

Lena A. Ohannesian; David Nadig; John D. Higgins; Max Rey; Stephen A. Martellucci


Archive | 1999

Sterolester in tablettierter fester Arzneiform Sterol esters in tableted solid dosage form

John D. Higgins; Stephen A. Martellucci


Archive | 1999

Preparation pharmaceutique contenant un sel d'acetaminophene et au moins un autre principe actif

Lena A. Ohannesian; David Nadig; John D. Higgins; Max Rey; Stephen A. Martellucci


Archive | 1999

Sterolester in tablettierter fester Arzneiform

John D. Higgins; Stephen A. Martellucci


Archive | 1999

A process for the preparation of water-dispersible sterol formulations

Brid Burruano; Michael R Hoy; John D. Higgins

Collaboration


Dive into the John D. Higgins's collaboration.

Top Co-Authors

Avatar

Adam C. Kinyon

Pennsylvania State University

View shared research outputs
Top Co-Authors

Avatar

Michael B. Hay

Pennsylvania State University

View shared research outputs
Researchain Logo
Decentralizing Knowledge