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Featured researches published by John D. Higgins.
Drug Development and Industrial Pharmacy | 2002
Shun Por Li; Stephen A. Martellucci; Adam C. Kinyon; Michael B. Hay; John D. Higgins
ABSTRACT The effect of different grades of hydroxyethyl cellulose (HEC) and hydroxypropyl methylcellulose (HPMC) on the film-formation and taste-masking ability for ibuprofen granules was evaluated. Three batches of coated ibuprofen granules were prepared using a roto-granulator, each with a different coating composition. Two grades of HEC [MW 300,000 (H) and MW 90,000 (L)] were combined with three different grades of HPMC [MW 11,000 (L), MW 25,000 (M) and MW 35,000 (H)] to prepare the coating solutions. Mechanical strength and physical properties of the polymer films were evaluated. Films made from HPMC (L)/HEC (H), HPMC (M)/HEC (H), and HPMC (H)/HEC (H) were stronger and more flexible than the HPMC (L)/HEC (L) films. The assay, dissolution, particle size distribution, and environmental scanning electron microscopy (ESEM) data of the three batches of the coated ibuprofen granules were similar. These data indicated that the two grades of HEC had equivalent film-coating properties. However, the HPMC (L)/HEC (L) film-coated granules showed better taste-masking characteristics (no burning after-taste) than the HPMC (L)/HEC (H) and HPMC (M)/HEC (H) film-coated granules. The ESEM data of the polymer films indicated that both HPMC (L)/HEC (H) and HPMC (M)/HEC (H) films exhibited more roughness and contained larger particles than the HPMC (L)/HEC (L) films. A hydration/dehydration study of the films revealed that HPMC (L)/HEC (H) and HPMC (M)/HEC (H) films were more susceptible to moisture effects, which subsequently led to a faster hydration rate of the polymer films. These data suggest that the molecular weight of the HEC affects the taste-masking ability of the resultant polymer film. The HEC (L) mixed well with the HPMC (L) to yield a uniform film that was more resistant to moisture effects. Hence, for optimum coating applications, particular attention should be paid to the molecular weight of the coating polymers to ensure that they are comparable to each other.
Archive | 1998
Brid Burruano; Michael R Hoy; John D. Higgins
Archive | 1998
Lena A. Ohannesian; David Nadig; John D. Higgins; Max Rey; Stephen A. Martellucci
Archive | 1999
Clemence K. Dartey; John D. Higgins; Brid Burruano
Archive | 1999
John D. Higgins; Stephen A. Martellucci
Archive | 1999
Lena A. Ohannesian; David Nadig; John D. Higgins; Max Rey; Stephen A. Martellucci
Archive | 1999
John D. Higgins; Stephen A. Martellucci
Archive | 1999
Lena A. Ohannesian; David Nadig; John D. Higgins; Max Rey; Stephen A. Martellucci
Archive | 1999
John D. Higgins; Stephen A. Martellucci
Archive | 1999
Brid Burruano; Michael R Hoy; John D. Higgins