John F. McGarrity

Hydrolysis of very reactive methylation agents - a rapid injection N. M. R. investigation.

Abstract By use of the recently described Rapid Injection N. M. R. technique it has been possible to measure the hydrolysis rates of 1 , 2 , and 3 at various temperatures; the activation parameters for these rapid reactions have been determined and discussed.

A facile synthesis of (2R,3E)-4-iodobut-3-en-2-ol and (2S,3E)-4-iodobut-3-en-2-yl chloroacetate

Abstract (2R,3E)-4-Iodobut-3-en-2-ol (( R )- 1 and (2S,3E)-4-Iodobut-3-en-2-yl chloroacetate (( S )- 7 ) of high enantiomeric purity can be prepared by a lipase catalysed kinetic resolution of racemic (E)-4-Iodobut-3-en-2-yl chloroacetate ( 7 ). The alcohol ( R )- 1 can be separated from the ester ( S )- 7 by a simple distillation.

Kinetics and mechanism of the acid-catalysed hydrolysis of diazomethane

The mechanism of the acid-catalysed hydrolysis of diazomethane in aqueous tetrahydrofuran has been elucidated and the rate constant for protonation by the hydronium ion has been evaluated as being ca. 108 l mol–1 s–1.