John Fahey

Examining Caesarean Section Rates in Canada Using the Robson Classification System

OBJECTIVE To determine the groups within the obstetric population contributing most substantially to the Caesarean section rate in five Canadian provinces. METHODS Hospital births from five participating provinces were grouped into Robsons 10 mutually exclusive and totally inclusive classification categories. The relative contribution of each group to the overall CS rate, relative size of group, and CS rate were calculated for British Columbia, Alberta, Ontario, Nova Scotia, and Newfoundland and Labrador for the four-year period from 2007-2008 to 2010-2011. RESULTS In all five provinces (accounting for approximately 64% of births in Canada), and for all years examined, the group making the largest relative contribution to the CS rate was women with at least one previous CS and a term, singleton, cephalic-presenting pregnancy (Robson Group 5). The CS rate for this group ranged from 76.1% in Alberta to 89.9% in Newfoundland and Labrador in 2010 to 2011, accounting for 11.3% of all deliveries. The rate of CS for Group 5 decreased slightly over the four years, except in Ontario. The next largest contributing group was nulliparous women with a term, singleton, cephalic-presenting pregnancy. Those with induced labour or Caesarean section before labour (Robson Group 2) had CS rates ranging from 34.4% in Nova Scotia to 44.6% in British Columbia (accounting for 13.1% of all deliveries), and those with spontaneous onset of labour (Robson Group 1) had CS rates of 14.5% to 20.3% in 2010 to 2011 (accounting for 23.6% of all deliveries). CONCLUSION All hospitals and health authorities can use this standardized classification system as part of a quality improvement initiative to monitor Caesarean section rates. This classification system identifies relevant areas for interventions and resources to reduce rates of Caesarean section.

An Outcome-based Approach for the Creation of Fetal Growth Standards: Do Singletons and Twins Need Separate Standards?

Contemporary fetal growth standards are created by using theoretical properties (percentiles) of birth weight (for gestational age) distributions. The authors used a clinically relevant, outcome-based methodology to determine if separate fetal growth standards are required for singletons and twins. All singleton and twin livebirths between 36 and 42 weeks’ gestation in the United States (1995–2002) were included, after exclusions for missing information and other factors (n = 17,811,922). A birth weight range was identified, at each gestational age, over which serious neonatal morbidity and neonatal mortality rates were lowest. Among singleton males at 40 weeks, serious neonatal morbidity/mortality rates were lowest between 3,012 g (95% confidence interval (CI): 3,008, 3,018) and 3,978 g (95% CI: 3,976, 3,980). The low end of this optimal birth weight range for females was 37 g (95% CI: 21, 53) less. The low optimal birth weight was 152 g (95% CI: 121, 183) less for twins compared with singletons. No differences were observed in low optimal birth weight by period (1999–2002 vs. 1995–1998), but small differences were observed for maternal education, race, parity, age, and smoking status. Patterns of birth weight-specific serious neonatal morbidity/neonatal mortality support the need for plurality-specific fetal growth standards.

Twin-twin transfusion syndrome: a population-based study.

OBJECTIVE: To study the incidence and mortality and morbidity rates of twin–twin transfusion syndrome in a complete population-based cohort in Nova Scotia. METHODS: A population-based cohort study of all monochorionic diamniotic twin pregnancies of 20 weeks of gestation or longer born to Nova Scotia (Canada) residents between 1988 and 2000 was examined. The effect of gestational age adjustment and birth weight discordancy of more than 20% on mortality and 1-year survival was studied. Other outcomes studied included birth depression, respiratory distress syndrome, chronic lung disease, interventricular hemorrhage, periventricular leukomalacia, acute renal failure, and congestive heart failure. RESULTS: Of 404 monochorionic-diamniotic twin pregnancies examined, 48 were identified with twin–twin transfusion syndrome. Total mortality rates per pregnancy were significantly greater in the twin–twin transfusion syndrome group than in the remainder of our monochorionic diamniotic population (P < .01). However, when adjusted for gestational age, mortality failed to achieve statistical significance. Similarly, no differences were noted for 1-year survival and other outcomes of liveborn infants after gestational age adjustment. Discordance in birth weight predicted a higher incidence of morbid outcomes per pregnancy, but this effect was lost after gestational age adjustment. CONCLUSION: Increased morbidity and mortality of twins with twin–twin transfusion syndrome is likely to be due to a higher incidence of preterm birth. Birth weight discordancy was not found to be an independent predictor of mortality after controlling for gestational age and twin-twin transfusion syndrome. LEVEL OF EVIDENCE: II-2

The effect of specimen temperature on the polymerization of a resin-composite

OBJECTIVE To use rapid scan FT-IR and Knoop microhardness to determine the effect of specimen temperature on the rate and extent of polymerization of a dental resin. METHODS Two-millimeter thick specimens of shade A2 Tetric EvoCeram were light cured for 20s at 22, 26, 30, and 35°C. The IR spectrum was obtained at the bottom of the specimens at a rate of 3 measurements per second for the first 5 min, and then again 2h later. The Knoop microhardness was measured at the bottom of the samples in the region where the IR spectrum was recorded at 5 min and 2h after light curing. Data were statistically analyzed using mixed model ANOVA (with Fishers PLSD) to examine the effect of temperature, time and their interaction. The rate of conversion was determined using first differences and smoothed using a cubic spline procedure. RESULTS The bottom surfaces of the samples light cured at 22, 26, 30 and 35°C were all significantly different from each other (p<0.05). The higher temperature resulted in higher degree of conversion and Knoop microhardness values, and faster maximum rate of polymerization, which also occurred sooner. One second after the light was turned on, the rate of conversion was 106% faster at 35°C than at 22°C (p=0.003). Regression analysis showed a positive linear correlation between the degree of conversion and Knoop microhardness (r²=0.93). SIGNIFICANCE A relatively small difference in temperature can have a large and significant effect on the rate and extent of polymerization of dental resin. Consequently laboratory studies comparing the performance of resins should be conducted at clinically relevant temperatures.

Trends in Optimal, Suboptimal, and Questionably Appropriate Receipt of Antenatal Corticosteroid Prophylaxis

OBJECTIVE: To conduct a population-based study to assess rates of optimal, suboptimal, and questionably appropriate administration of antenatal corticosteroid (betamethasone or dexamethasone) use. METHODS: All live births in Nova Scotia, Canada, from 1988 to 2012 were included in the study. Temporal trends in optimal (proportion of live births at 24–34 weeks of gestation exposed to antenatal corticosteroids between 24 hours and 7 days before delivery), suboptimal (proportion of live births at 24–34 weeks of gestation exposed to antenatal corticosteroids less than 24 hours or more than 7 days before delivery), and questionably appropriate exposure to antenatal corticosteroids (proportion of live births 35 weeks of gestation or greater exposed to antenatal corticosteroids) were quantified using odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Among 246,459 live births between 1988 and 2012, 2.5% received a partial or a full course of antenatal corticosteroids. The rate of antenatal corticosteroid exposure for neonates born between 28 and 32 weeks of gestation increased from 39.5% in 1988–1992 to 79.3% in 2008–2012, whereas exposure for those born at 33–34 weeks of gestation increased from 14.3 to 49.7%. Optimal antenatal corticosteroid receipt increased from 10% in 1988 to 23% in 2012 (OR 2.7, 95% CI 1.6–4.5), suboptimal administration increased from 7 to 34% (OR 6.7, 95% CI 3.9–11.6), and questionably appropriate administration increased from 0.2% in 1988 to 1.7% in 2012 (OR 7.5, 95% CI 4.9–11.3). Of the women who received antenatal corticosteroids in 2012, 52% delivered at 35 weeks of gestation or greater. CONCLUSION: Temporal increases in optimal exposure to antenatal corticosteroids have been matched by increases in suboptimal and questionably appropriate receipt of antenatal corticosteroids, highlighting the need for accurate preterm delivery prognostic models. LEVEL OF EVIDENCE: II

Temporal trends and regional variations in severe maternal morbidity in Canada, 2003 to 2007.

OBJECTIVE To identify temporal trends and regional variations in severe maternal morbidity in Canada using routine hospitalization data. METHODS We used a previously identified set of International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10CA) and Canadian Classification of Interventions (CCI) codes to estimate rates of severe maternal morbidity in Canada (excluding Quebec) for 2003 to 2007 using the Discharge Abstract Database of the Canadian Institute for Health Information (CIHI). Rates and 95% confidence intervals were calculated by year and within each province and territory and contrasted using the chi-square or Fisher exact test. RESULTS The overall rate of severe maternal morbidity was 13.8 per 1000 deliveries (95% CI 13.6 to 14.0). Five provinces or territories had rates that were significantly higher than those in the rest of the country: Newfoundland and Labrador (19.0 per 1000; 95% CI 17.2 to 20.8), Saskatchewan (16.9 per 1000; 95% CI 15.9 to 18.0), Alberta (15.4 per 1000; 95% CI 14.9 to 15.9), Northwest Territories (22.5 per 1000; 95% CI 18.0 to 27.7), and Nunavut (20.2 per 1000; 95% CI 14.2 to 27.8). Rates of some illnesses declined (e.g., eclampsia rates decreased from 12.4 in 2003 to 5.7 per 10 000 deliveries in 2007, P<0.001), while others increased (e.g., postpartum hemorrhage with blood transfusion rates increased from 36.6 in 2003 to 44.3 per 10 000 deliveries in 2007, P<0.001). Interprovincial/territorial contrasts showed several disparities with respect to specific maternal illnesses. CONCLUSION The observed temporal trends and regional disparities in severe maternal morbidity may represent important population health phenomena, and further investigation is required to assess their importance.

Contribution of prepregnancy body mass index and gestational weight gain to caesarean birth in Canada

BackgroundOverweight and obese women are known to be at increased risk of caesarean birth. This study estimates the contribution of prepregnancy body mass index (BMI) and gestational weight gain (GWG) to caesarean births in Canada.MethodsWe analyzed data from women in the Canadian Maternity Experiences Survey who had a singleton term live birth in 2005-2006. Adjusted odds ratios for caesarean birth across BMI and GWG groups were derived, separately for nulliparous women and parous women with and without a prior caesarean. Population attributable fractions of caesarean births associated with above normal BMI and excess GWG were calculated.ResultsThe overall caesarean birth rate was 25.7%. Among nulliparous and parous women without a previous caesarean birth, rates in obese women were 45.1% and 9.7% respectively, and rates in women who gained above their recommended GWG were 33.5% and 8.0% respectively. Caesarean birth was more strongly associated with BMI than with GWG. However, due to the high prevalence of excess GWG (48.8%), the proportion of caesareans associated with above normal BMI and excess GWG was similar [10.1% (95% CI: 9.9-10.2) and 10.9% (95% CI: 10.7-11.1) respectively]. Overall, one in five (20.2%, 95% CI: 20.0-20.4) caesarean births was associated with above normal BMI or excess GWG.ConclusionsOverweight and obese BMI and above recommended GWG are significantly associated with caesarean birth in singleton term pregnancies in Canada. Strategies to reduce caesarean births must include measures to prevent overweight and obese BMI prior to conception and promote recommended weight gain throughout pregnancy.

Intra- and inter-brand accuracy of four dental radiometers

This study measured the accuracy and precision of four commercial dental radiometers. The intra-brand accuracy was also determined. The light outputs from 14 different curing lights were measured three times using four brands of dental radiometers and the results were compared to two laboratory-grade power meters that were used as the “gold standard”. To ensure proper representation, three examples of each brand of dental radiometer were used. Data collected was analyzed using ANOVA, with 95% confidence intervals, comparing the laboratory-grade meters to the dental radiometers. Bioequivalence was established where the confidence interval for the irradiance values was within ±20% of the “gold standard” reading. Forest plots were used to highlight bioequivalence values. The two laboratory-grade meters differed by less than 0.6%. Overall, all three examples of the Bluephase and SDI radiometers as well as two examples of the LEDRadiometer and one CureRite meter were bioequivalent to the gold standard. However, the type of curing light measured had a significant effect on the accuracy of the radiometer. There was significant variability of the irradiance readings between radiometer brands, and between irradiance values recorded by the three samples of each brand studied. This made it impossible to definitively rank the radiometer brands for accuracy. Within the ±20% bioequivalence limits of this study, there was a clinically significant difference in the irradiance readings between radiometer brands and the choice of curing light affected the results. There was also significant variation in irradiance readings reported by different examples of the same brand of radiometer. Whether in clinical practice or in research, dental radiometers should not be used when either the irradiance or energy delivered needs to be accurately known.

Effects of socioeconomic position and clinical risk factors on spontaneous and iatrogenic preterm birth

BackgroundThe literature shows a variable and inconsistent relationship between socioeconomic position and preterm birth. We examined risk factors for spontaneous and iatrogenic preterm birth, with a focus on socioeconomic position and clinical risk factors, in order to explain the observed inconsistency.MethodsWe carried out a retrospective population-based cohort study of all singleton deliveries in Nova Scotia from 1988 to 2003. Data were obtained from the Nova Scotia Atlee Perinatal Database and the federal income tax T1 Family Files. Separate logistic models were used to quantify the association between socioeconomic position, clinical risk factors and spontaneous preterm birth and iatrogenic preterm birth.ResultsThe study population included 132,714 singleton deliveries and the rate of preterm birth was 5.5%. Preterm birth rates were significantly higher among the women in the lowest (versus the highest) family income group for spontaneous (rate ratio 1.14, 95% confidence interval (CI) 1.03, 1.25) but not iatrogenic preterm birth (rate ratio 0.95, 95% CI 0.75, 1.19). Adjustment for maternal characteristics attenuated the family income-spontaneous preterm birth relationship but strengthened the relationship with iatrogenic preterm birth. Clinical risk factors such as hypertension were differentially associated with spontaneous (rate ratio 3.92, 95% CI 3.47, 4.44) and iatrogenic preterm (rate ratio 14.1, 95% CI 11.4, 17.4) but factors such as diabetes mellitus were not (rate ratio 4.38, 95% CI 3.21, 5.99 for spontaneous and 4.02, 95% CI 2.07, 7.80 for iatrogenic preterm birth).ConclusionsSocioeconomic position and clinical risk factors have different effects on spontaneous and iatrogenic preterm. Recent temporal increases in iatrogenic preterm birth appear to be responsible for the inconsistent relationship between socioeconomic position and preterm birth.

Recent Changes in Maternal Characteristics by Socioeconomic Status

OBJECTIVE To describe changes in maternal characteristics by socioeconomic status, in order to provide a context for recent changes in the frequency of obstetric procedures and outcomes, and information for health planning purposes. METHODS All NS residents who delivered between 1988 and 2007 were included in the study. Information on maternal characteristics was obtained from the Nova Scotia Atlee Perinatal Database, and socioeconomic status information was obtained through a confidential link with federal income tax T1 Family Files (1988 to 2003). RESULTS Total births to women < 20 years of age were high (31.5% in 2003) and increased in the lowest family income group between 1988 and 2003, while rates were low (0.7% in 2003) and decreased in the highest family income group. Total births to women >/= 35 years increased by 136% (95% CI 122, 150) between 1988-89 and 2006-07. Births to women with a weight >/= 90 kg also increased, while those to smokers decreased in all socioeconomic groups. The proportion of births to multiparous women with a previous low birth weight infant did not change (-5 %, 95% CI -14, 6), although births to women with a previous perinatal death declined by 52% (95% CI -60,-42). CONCLUSION Large secular changes have occurred in maternal characteristics over the past two decades, and the magnitude of these changes has differed by socioeconomic status.