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Dive into the research topics where John H. Fitchen is active.

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Featured researches published by John H. Fitchen.


Vaccine | 1995

Plant virus expressing hybrid coat protein with added murine epitope elicits autoantibody response.

John H. Fitchen; Roger N. Beachy; Mich B. Hein

A modified tobacco mosaic virus (TMV) was used to direct the synthesis of TMV coat protein hybrids containing a 13 amino acid sequence of the murine zona pellucida ZP3 protein. This hybrid protein was found to be robust and accumulate to high concentrations in inoculated plants. Virus-like particles containing the hybrid coat protein could be readily purified from infected plant tissue. Parenteral immunization with these virus-like particles as antigen resulted in serum antibody recognizing ZP3 epitope in C57BL/6J and BALB/cBy mice. The antibodies recognized synthetic ZP3 peptide and the authentic murine ZP3 glycoprotein. Antibodies were recruited in vivo to the zone pellucida in female mice.


Annual Review of Microbiology | 1993

Genetically Engineered Protection Against Viruses in Transgenic Plants

John H. Fitchen; Roger N. Beachy


Proceedings of the National Academy of Sciences of the United States of America | 1999

Protective immunity against murine hepatitis virus (MHV) induced by intranasal or subcutaneous administration of hybrids of tobacco mosaic virus that carries an MHV epitope

Moses Koo; Mohammed Bendahmane; Gerard A. Lettieri; Alyssa D. Paoletti; Thomas E. Lane; John H. Fitchen; Michael J. Buchmeier; Roger N. Beachy


Journal of Virology | 1997

Studies of coat protein-mediated resistance to tobacco mosaic tobamovirus: correlation between assembly of mutant coat proteins and resistance.

Mohammed Bendahmane; John H. Fitchen; Guangming Zhang; Roger N. Beachy


Archive | 1995

Method for using tobacco mosaic virus to overproduce peptides and proteins

John H. Fitchen; Roger N. Beachy


Annals of the New York Academy of Sciences | 1996

Use of Plant Viruses for Delivery of Vaccine Epitopesa

Roger N. Beachy; John H. Fitchen; Mich B. Hein


Virology | 1995

Studies of coat protein-mediated resistance to TMV. I. The PM2 assembly defective mutant confers resistance to TMV.

W.Gregg Clark; John H. Fitchen; Roger N. Beachy


Archive | 1997

J chain polypeptide targeting molecule linked to an imaging agent

Andrew C. Hiatt; Mich B. Hein; John H. Fitchen


Archive | 1997

Epithelial cell targeting agent

Mich B. Hein; Andrew C. Hiatt; John H. Fitchen


Archive | 1998

Novel epithelial tissue targeting agent

Mich B. Hein; Andrew C. Hiatt; John H. Fitchen

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Roger N. Beachy

Donald Danforth Plant Science Center

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Thomas E. Lane

Scripps Research Institute

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W.Gregg Clark

Washington University in St. Louis

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Moses Koo

Gyeongsang National University

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