John Hidalgo

Preparation and Properties of a Heat‐Treated Human Plasma Protein Fraction

By precipitating a particular mixture of albumins and globulins from an Effluent IV‐1 prepared by a modified fractionation procedure, a safe and osmotically active fraction was obtained from human plasma in high yield. The HTPF thus obtained is devoid of cat depressor activity. Both fibrinogen and gamma globulin can be recovered from plasma by the method described.

Effect of drugs on the cardiac conditioned response of dogs

Abstract Dogs were conditioned to an anxiety response characterized by an increase in heart rate upon presentation of a musical tone. Meprobamate, chlordiazepoxide and diazepam effectively prevented the cardiac conditioned response. Phenobarbital and chlorpromazine were less effective. Amphetamine, 1.5 mg kg orally, also blocked the cardiac conditioned response. Atropine, meperidine, caffeine, imipramine and α-methyl-dopa had no effect on the cardiac conditioned response. Morphine and methyl phenidate were clearly active only in doses producing marked side effects. Ethanol in relatively small doses was mildly effective.

Etoxadrol (CL-1848C) a new dissociative anesthetic: studies in primates and other species.

L-l848C, the dextrorotatory isomer of c 2-ethyl-2-phenyl-4(2-piperidyl) (1,3dioxolane hydrochloride) from the dace mate, is a new agent which in primates has anesthetic properties similar to those of ketamine. The overt effects of CG1848C and ketamine in other animal species are also similar. Ketamine has been reported to induce in man a profound analgesia and somnolence,’ for which Domino and associates2 first proposed the term “dissociative anesthetic.”

Influence of dosage regimen on responses of the arcuate nucleus to subcutaneous injection of a protein hydrolysate

The effect of administration of a glutamate-containing protein hydrolysate on the arcuate nucleus of 10-day-old mice was studied by two methods. Arcuate nucleus damage resulted when administration was by a single large subcutaneous dose (100 ml/kg). When the same total dose was administered subcutaneously in five small doses (20 ml/kg) over a period of 8 h, the damage to the arcuate nucleus did not occur. The latter method of administration was to simulate a clinical infusion. The results demonstrate that there is no hazard to the arcuate nucleus w-en glutamate-containing protein hydrolysates are administered by infusion.

Cardiovascular profile of the antihypertensive agent, guanadrel.

Summary Guanadrel was evaluated for its cardiovascular profile and was found to possess properties which are desirable in the treatment of hypertension. The compound causes blockade of the sympathetic nerve ending and depletion of peripheral and “hypothalamic” catecholamines. Guanadrel does not deplete intestinal norepinephrine, which may be the reason for the fact that it does not produce diarrhea when administred experimentally or clinically.