John Hughes Reynolds

Chemical and Biological Studies of a Cigarette That Heats Rather Than Burns Tobacco

Cigarettes can be developed that heat rather than burn tobacco. Such products would be expected to have less “tar” and other combustion products than cigarettes that burn tobacco. With one product of this type, benzo(a)pyrene, N‐nitrosamines, phenolic compounds, acetaldehyde, acrolein, hydrogen cyanide, and N‐heterocyclic compounds have been reduced 10‐ to 100‐fold compared to the Kentucky reference (1R4F) cigarette, a representative low‐tar cigarette. The yields of nicotine and carbon monoxide from this new cigarette are less than the yields of 95% and 75%, respectively, of the cigarettes sold in the United States during 1988. Nicotine absorption from smoking this new cigarette is not significantly different from that of tobacco‐burning cigarettes yielding equivalent levels of nicotine. The urine mutagenicity of smokers of new cigarettes is significantly less (P < .05) than that of smokers of tobacco‐burning cigarettes and is not significantly different (P > .10) from that of nonsmokers. We conclude that cigarettes which heat rather than burn tobacco can reduce the yield of tobacco combustion products. This simplification of smoke chemistry had no effect on nicotine absorption in smokers and resulted in a reduction of biological activity in smokers as measured by urine mutagenicity.

Type a personality: Correlations with personality variables and nonverbal emotional expressions during interpersonal competition

Abstract Facial and other nonverbal behaviors of 52 male and female participants in an interpersonal anagrams competition were correlated with a variety of self-report personality measures. Facial expressions suggestive of negative affect were significantly positively correlated with the Framingham Type A scale and the Job Involvement and Hard-Driving subscales of the Jenkins Activity Survey. A composite nonverbal index correlated significantly with Framingham Type A, Jenkins Job Involvement and the Extraversion scale of the Eysenck Personality Questionnaire. The pattern of correlations between the nonverbal and personality measures supported the view that Type A individuals are characterized by both self-reports of and facial expression of more anger/hostility than are Type B individuals.

Absorption of Nicotine from a Cigarette That Does Not Burn Tobacco

Ten smokers participated in a study to compare the absorption of nicotine from the smoke aerosol of a new cigarette that heats, but does not burn tobacco (test) with a cigarette that burns tobacco (reference). The average plasma nicotine concentrations obtained by the 7th test cigarette (13 ng/ml) and 7th reference cigarette (24 ng/ml) were proportional to the nicotine yielded by the two cigarettes as determined under Federal Trade Commission machine-smoking conditions. These data demonstrate that the smoke aerosol obtained by smoking a cigarette which heats tobacco produces plasma profiles of nicotine that are similar to the profiles obtained from smoking a cigarette that burns tobacco.