John Kapp

The Effect of Isordil and Cyclospasmol on Vascular Spasm Induced in the Basilar Artery of the Cat

Vasospasm of the basilar artery of the cat was induced by subarachnoid bleeding and was observed by a transoral approach to the vessel. Intravenous Isordil (2 to 4 mg/kg) given following vasospasm produced vasodilatation with minimal arterial hypotension. Cyclospasmol, administered intravenously after vasospasm or orally prior to vasospasm, was ineffective in relieving or preventing basilar artery spasm.

Further physiological observations during induced basilar artery spasm in cats and dogs

Abstract In these experiments, it was determined that the previously described basilar artery spasm in the cat induced by direct exposure to blood or platelet fraction could be similarly produced in the dog. It was also found that spasmogenic platelet fraction was not deactivated by in vitro exposure to CSF for 24 hours, and that platelet fraction was active when injected intrathecally in vivo , thus expanding the significance of our earlier report of the spasmogenic properties of platelet fractions when irrigated directly upon the basilar artery of the cat.

Prevention of air embolism in the decerebrate preparation.

Abstract A method for rapid decerebration by suction and a simple technique to prevent air embolism is described