John Kenwright

Axial movement and tibial fractures. A controlled randomised trial of treatment

Diaphyseal fractures of the tibia in 80 patients were treated by external skeletal fixation using a unilateral frame, either in a fixed mode or in a mode which allowed the application of a small amount of predominantly axial micromovement. Patients were allocated to each regime by random selection. Fracture healing was assessed clinically, radiologically and by measurement of the mechanical stiffness of the fracture. Both clinical and mechanical healing were enhanced in the group subjected to micromovement, compared to those treated with frames in a fixed mode possessing an overall stiffness similar to that of others in common clinical use. The differences in healing time were statistically significant and independently related to the treatment method. There was no difference in complication rates between treatment groups.

Strain rate and timing of stimulation in mechanical modulation of fracture healing

Fracture of the long bones results in a repair process that has the potential to restore the anatomic morphology and mechanical integrity of the bone without scar tissue. The repair process can occur in two patterns. In the first, under conditions of rigid stabilization, direct osteonal remodeling of the fracture line can occur with little or no external callus, a process known as direct bone repair. The second pattern of repair involves bridging of the fragments with external callus and formation of bone in the fracture site by endochondral healing. This type of repair is known as indirect bone healing and occurs under less rigid interfragmentary stabilization. The rate of healing and the extent of callus in this type of repair can be modulated by the mechanical conditions at the fracture site. Applying cyclic interfragmentary micromotion for short periods has been shown to influence the repair process significantly, and characteristics of this stimulus influence the healing response observed. In the current study, a short term interfragmentary cyclic micromovement applied at a high strain rate induced a greater amount of periosteal callus than the same stimulus applied at a low strain rate. This high strain rate stimulus applied later in the healing period significantly inhibited the progress of healing. The beneficial effect of this particular biophysic stimulus early in the healing period may be related to the viscoelastic nature of the differentiating connective tissues in the early endochondral callus. In the early endochondral callus, high rates of movement induce a greater deformation of the fracture fragments because of the stiffening of the callus. Alternatively, the transduction pathway may involve streaming potentials as a result of the high movement rate.

Leg lengthening over an intramedullary nail

Distraction osteogenesis is widely used for leg lengthening, but often requires a long period of external fixation which carries risks of pin-track sepsis, malalignment, stiffness of the joint and late fracture of the regenerate. We present the results of 20 cases in which, in an attempt to reduce the rate of complications, a combination of external fixation and intramedullary nailing was used. The mean gain in length was 4.7 cm (2 to 8.6). The mean time of external fixation was 20 days per centimetre gain in length. All distracted segments healed spontaneously without refracture or malalignment. There were three cases of deep infection, two of which occurred in patients who had had previous open fractures of the bone which was being lengthened. All resolved with appropriate treatment. This method allows early rehabilitation, with a rapid return of knee movement. There is a lower rate of complications than occurs when external fixation is used on its own. The time of external fixation is shorter than in other methods of leg lengthening. The high risk of infection calls for caution.

Mechanical influences on tibial fracture healing

Selected studies are summarized that measure interfragmentary fracture displacement in 6° of freedom at intervals throughout healing in groups of patients with tibial diaphyseal fractures treated by external skeletal fixation. The results are compared with those obtained from experimental studies in which the ideal mechanical conditions for fracture healing were predicted. A finite element analysis model of the healing tibial fracture also was developed. Measured data were used for the analysis, and stress and strain patterns were defined for different stages of healing. Interfragmentary movement measured in the first 6 weeks after injury usually is a magnitude smaller in patients treated by external fixation than in patients treated with cast immobilization. This movement can be much smaller than that predicted to be optimal by experimental studies. A greater amplitude can be achieved, even in stable fractures, by ensuring patient activity. The interfragmentary movement is elastic during loading activity and is generally sinusoidal during steady walking. At the time of dynamization (the unlocking of the frame), a permanent set occurs at the fracture site in all planes. The cyclical movement range in each plane often decreases immediately after unlocking. The model analysis study of fracture healing predicts that tissue damage may occur in the later (hard callus) phase of healing, even while the fixation device is in place, because of abnormally high stresses and strains. This study indicates that fracture mechanics should be controlled more rigorously to provide amplitudes of movement in the first 4 to 6 weeks after fracture. The rigidity of fixation should be increased in the subsequent weeks until the fracture has healed and the frame is removed.

Tibial external fixation, weight bearing, and fracture movement.

Axial fracture movement and loading has been measured during weight bearing in 45 patients with tibial diaphyseal fractures treated with unilateral external skeletal fixation. Mean axial fracture displacement reached a maximum of 0.6 mm between seven and 12 weeks postfracture. Very little movement occurred during the first five weeks after fracture. A micromovement module attached to the fixator increased axial movement at the fracture site by 50% during walking. Weight bearing reached 75% of mean body weight by ten weeks after the fracture. Weight bearing was not decreased by any biofeedback mechanism. A randomized prospective clinical study of diaphyseal tibial fractures treated with external fixation showed a significant reduction in time to healing when micromovement was imposed. Controlled fracture site movement can be imposed very early after fixator frame application when mechanical stimulation may be most effective, and the active loading by the patient is least.

Fibula and its ligaments in load transmission and ankle joint stability

A study was made of the role of the fibula in weightbearing and its contribution to ankle joint stability in 10 anatomic specimen lower limbs. On axial loading of the lower limb, the fibula was found to take an average of 17% of a 1500 N axial load. The proportion of the load carried by the fibula increased with the total loading. It also increased when the line of load was displaced laterally and when the ankle joint was in dorsiflexion and decreased when the line of loading shifted medially or the joint was plantar flexed. With loading, the lateral malleolus migrated distally relative to the medial malleolus, except after fibular osteotomy, when it migrated proximally. There was an approximately inverse relationship between proportional fibular loading and distal fibular migration. Cutting the inferior tibiofibular ligament reduced the proportional load in the fibula and increased its distal migration. The interosseous membrane modified the load distribution between the tibia and the fibula, with the distal fibula carrying a higher proportion of the axial load than did the proximal. Surgical repair of a ruptured inferior tibiofibular ligament, using either 1 or 2 screws, was associated with an abnormal pattern of load distribution and fibular displacement.

Biomechanical measurement of fracture healing

Three techniques for measuring fracture healing are presented. These techniques are: (1) use of strain gauge measurements of the forces in an external fixator to determine fracture stiffness, (2) measurement of the vibration modes of a fractured long bone compared to the unfractured contralateral and (3) comparison of the ultrasound velocity across the fracture site with that for the normal unfractured bone. Examples of clinical results obtained using these techniques are presented, and the advantages and disadvantages of each technique are discussed.

Fracture after distraction osteogenesis

We reviewed 173 patients undergoing distraction osteogenesis to determine the incidence, location and timing of fractures occurring as a complication of the procedure. There were 17 fractures in 180 lengthened segments giving an overall rate of fracture of 9.4%. Unexpectedly, the pattern and location of the fractures were very variable; six were within the regenerate itself, six at the junction between the regenerate and the original bone and five at distant sites in the limb. Of those occurring in the regenerate, five were noted to be associated with compression and partial collapse of the regenerate. In three patients collapse and deformity developed gradually in the distracted segment over the six months after removal of the frame. The method of treatment of these fractures should be chosen to take into account multiple factors, which are additional and often different from those to be considered during management of acute traumatic injuries. Internal fixation appears to be most appropriate for displaced fractures, although in small children, or in those in whom there has been, or is, infection of the screw tracks, a new period of treatment using external fixation may be needed. Fixation by intramedullary nailing was associated with a risk of infection, even if screw tracks were assessed as healthy at the time of insertion of the nail. Internal fixation with the use of plates is safe for displaced, unstable fractures in children.

The morphological basis of increased stiffness of rabbit tibialis anterior muscles during surgical limb-lengthening

When the tibialis anterior muscle of the rabbit is progressively stretched during surgical limb distraction, the muscle fibres lengthen by addition of new serial sarcomeres, provided that stretch is carried out at an appropriate rate. However, in spite of the apparent adaptation to the new functional length, range of joint movement is greatly decreased. In this study we have first, made measurements of the passive tension developed by distracted muscles over the range of joint movement and secondly made quantitative measurements of endomysial and perimysial connective tissue content. It was found that at all ankle joint angles greater than 90°, the passive tension developed by the distracted muscles was greater than both contralateral and sham‐operated controls. Image analysis showed that the ratio of collagen to contractile material was increased in distracted muscles compared with muscles from sham‐operated controls, due to increased deposition of collagen type III. Scanning electron microscopy showed the presence of a dense perimysial weave surrounding the distracted muscle fibres. These quantitative and qualitative changes in the connective tissue component could account for the increased stiffness demonstrated by the physiological measurements. It would seem that in distracted muscle the connective tissue element adapts less readily than the contractile component, with prolonged stretch leading to damage to the perimysial and endomysial network, with subsequent fibrosis and loss of muscle compliance. Such changes could help explain the loss of range of movement noted in the distracted limbs of patients undergoing surgical limb‐lengthening and in other conditions that result in muscle contractures.

Fracture stiffness measurement in the assessment and management of tibial fractures.

Fracture stiffness results obtained from patients with tibial fractures treated with external skeletal fixation are reviewed. A threshold value of bending fracture stiffness at which removal of the external fixator and functional loading of the fracture can be prescribed is proposed to be 15 N m degree(-1). The logarithm of the bending stiffness was found to give a linear relationship with time post-fracture, thus implying that stiffness increases exponentially with time. From three previous studies of mechanical measurements of fracture healing, the fracture stiffnesses at which independent weight-bearing was permitted were determined and were found to be comparable with the threshold value of stiffness proposed in this paper. A review of previously published data for the in-vivo stiffness of intact tibiae showed that the stiffness required for functional healing of a tibial fracture is between 17 and 25% of that of the intact tibia.