Is this you? Create Your Porfile
Avatar

John L. Kane

Genzyme

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where John L. Kane is active.

Explore More

Publication

Featured researches published by John L. Kane.

Bioorganic & Medicinal Chemistry Letters | 2009

Discovery of novel sphingosine kinase 1 inhibitors.

Yibin Xiang; Gary Asmussen; Michael Booker; Bradford Hirth; John L. Kane; Junkai Liao; Kevin D. Noson; Christopher Yee

Sphingosine kinase 1 (SK1) is an important enzyme that regulates the balance between ceramide and sphingosine-1-phosphate (S1P). Potent and novel SK1 inhibitors (6ag, 9ab and 12aa) have been discovered through a series of modifications of sphingosine (1), the substrate of this enzyme.

Bioorganic & Medicinal Chemistry Letters | 2010

Discovery of novel sphingosine kinase-1 inhibitors. Part 2 *

Yibin Xiang; Bradford Hirth; John L. Kane; Junkai Liao; Kevin D. Noson; Christopher Yee; Gary Asmussen; Maria Fitzgerald; Christine Klaus; Michael Booker

Building on our initial work, we have identified additional novel inhibitors of sphingosine kinase-1 (SK1). These new analogs address the shortcomings found in our previously reported compounds. Inhibitors 51 and 54 demonstrated oral bioavailability in a rat PK study.

Bioorganic & Medicinal Chemistry Letters | 2003

Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria.

John L. Kane; Bradford Hirth; Beirong Liang; Brian B. Gourlie; Sharon Nahill; Gary Barsomian

Bioorganic & Medicinal Chemistry Letters | 2005

Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport.

Bradford Hirth; Shuang Qiao; Lisa M. Cuff; Brian M. Cochran; Marko J. Pregel; Jill S. Gregory; Scott F. Sneddon; John L. Kane

Archive | 2008

2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors

Craig S. Siegel; Cecilia M. Bastos; David J. Harris; Angeles Dios; Edward R. Lee; Richard Silva; Lisa M. Cuff; Mikaela Levine; Cassandra Celatka; Frederic Vinick; Thomas H. Jozefiak; Yibin Xiang; John L. Kane; Junkai Liao

Archive | 2001

Modulators of TNF-α signaling

Scott F. Sneddon; John L. Kane; Bradford Hirth; Frederic Vinick; Shuang Qiao; Sharon Nahill; John M. Williams; Hans-Peter Biemann

Archive | 2007

Novel small molecules with selective cytotoxicity against human microvascular endothelial cell proliferation

John L. Kane; Bradford Hirth; Christopher Yee; Hans-Peter Biemann; Marko J. Pregel

Archive | 2009

INHIBITORS OF SPHINGOSINE KINASE 1

Yibin Xiang; Bradford Hirth; John L. Kane; Junkai Liao; Kevin D. Noson; Christopher Yee

Archive | 2015

TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS

John L. Kane; Gloria Matthews; Markus Metz; Michael Kothe; Jinyu Liu; Andrew Scholte

Archive | 2017

Colony stimulating factor-1 receptor (csf-1r) inhibitors

John L. Kane; Claude Barberis; Mark Czekaj; Paul Erdman; Barret Giese; Michael Kothe; Tieu-Binh Le; Jinyu Liu; Liang Ma; Markus Metz; Vinod F. Patel; Andrew Scholte; Patrick Shum; Limli Wei

Explore More

Collaboration

Dive into the John L. Kane's collaboration.

Top Co-Authors
Avatar

Bradford Hirth

Genzyme

View shared research outputs
Top Co-Authors
Avatar

Junkai Liao

Genzyme

View shared research outputs
Top Co-Authors
Avatar

Yibin Xiang

Genzyme

View shared research outputs
Top Co-Authors
Avatar

Frederic Vinick

Genzyme

View shared research outputs
Top Co-Authors
Avatar

Lisa M. Cuff

Genzyme

View shared research outputs
Top Co-Authors
Avatar

Angeles Dios

Genzyme

View shared research outputs
Top Co-Authors
Avatar

Cassandra Celatka

Genzyme

View shared research outputs
Top Co-Authors
Avatar

Cecilia M. Bastos

Genzyme

View shared research outputs
Top Co-Authors
Avatar

Christopher Yee

Genzyme

View shared research outputs
Top Co-Authors
Avatar

Craig S. Siegel

Genzyme

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge