John L. Ott | Researchain

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Featured researches published by John L. Ott.

Annals of the New York Academy of Sciences | 1971

IN VITRO AND IN VIVO METHODOLOGY FOR DETECTING AND EVALUATING INHIBITORS OF TRANSFER OF RESISTANCE FACTORS

John L. Ott; Lois J. Short; Donald H. Holmes

The transfer of antimicrobial resistance factors among the Enterobacteriaceae and a concern about their possible role in disease problems is of continuing worldwide interest. We wish to report here a simple in vitro plating procedure useful in a search for compounds that have an inhibitory effect on resistance transfer. An in vivo system employing gnotobiotic mice in which transfer of a resistance factor occurs efficiently between bacterial strains will also be described. In Vitro System

The Journal of Antibiotics | 1988

Enzymatic and chemical modifications of lipopeptide antibiotic A21978C: The synthesis and evaluation of daptomycin (LY146032).

Manuel Debono; Bernard J. Abbott; R. Michael Molloy; David S. Fukuda; Ann H. Hunt; Veronica M. Daupert; Frederick T. Counter; John L. Ott; Claude B. Carrell; Leonard C. Howard; La Verne D. Boeck; Robert L. Hamill

The Journal of Antibiotics | 1989

Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives

Manuel Debono; K. E. Willard; Herbert A. Kirst; Julie A. Wind; Gary D Crouse; Eddie Vi-Ping Tao; Jeffrey T. Vicenzi; F. T. Counter; John L. Ott; Earl E. Ose; Satoshi Omura

The Journal of Antibiotics | 1990

A80915, a new antibiotic complex produced by Streptomyces aculeolatus. Discovery, taxonomy, fermentation, isolation, characterization, and antibacterial evaluation.

David S. Fukuda; Jon S. Mynderse; Patrick J. Baker; Donnis M. Berry; Laverne Dwaine Boeck; Raymond C. Yao; Frederick P. Mertz; Walter Mitsuo Nakatsukasa; James A. Mabe; John L. Ott; F. T. Counter; P. W. Ensminger; Norris E. Allen; W. E. Alborn; J N Hobbs

Journal of Medicinal Chemistry | 1985

Orally absorbable cephalosporin antibiotics. 2. Structure-activity studies of bicyclic glycine derivatives of 7-aminodeacetoxycephalosporanic acid.

Stjepan Kukolja; Susan Elizabeth Draheim; Bernard J. Graves; David C. Hunden; Janice L. Pfeil; Robin D. G. Cooper; John L. Ott; F. T. Counter

The Journal of Antibiotics | 1990

A54145 a new lipopeptide antibiotic complex: microbiological evaluation.

F. T. Counter; Norris E. Allen; David S. Fukuda; J N Hobbs; John L. Ott; P. W. Ensminger; Jon S. Mynderse; D. A. Preston; C. Y. E. Wu

Journal of Medicinal Chemistry | 1988

Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.

Herbert A. Kirst; John E. Toth; Manuel Debono; K. E. Willard; Brenda Alethia Truedell; John L. Ott; F. T. Counter; A. M. Felty-Duckworth; Robert S. Pekarek

The Journal of Antibiotics | 1982

Structure-activity studies among 16-membered macrolide antibiotics related to tylosin.

Herbert A. Kirst; Gene M. Wild; Richard H. Baltz; Robert L. Hamill; John L. Ott; F. T. Counter; Earl E. Ose

Journal of Medicinal Chemistry | 1975

Chemistry of cephalosporin antibiotics. 28. Preparation and biological activity of 3-(substituted)vinyl cephalosporins.

J. Alan Webber; John L. Ott; Robert T. Vasileff

The Journal of Antibiotics | 1989

Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides.

Herbert A. Kirst; K. E. Willard; Manuel Debono; John E. Toth; Brenda Alethia Truedell; James Patrick Leeds; John L. Ott; A. M. Felty-Duckworth; F. T. Counter; Earl E. Ose; Gary D Crouse; J. M. Tustin; Satoshi Omura

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