John P Devlin

The design and synthesis of immune regulatory agents: targets and approaches

This report will provide an assessment of the progress that has been made in the design of immune regulatory agents and will draw attention to those areas that are considered to offer the greatest promise. We will begin with a brief outline of the matrix of cellular events that are associated with the immune response. Compounds that have been reported to alter these events are discussed in the context of the segment of this matrix wherein their primary activity is observed. Emphasis is placed on the diverse structural groups encountered and the opportunities for innovation in synthesis and the analysis of structure-activity relationships. Substances that have demonstrated clinical potential are highlighted