John P. Phair

Influenza virus infection of the guinea pig: Immune response and resistance

Guinea pigs were inoculated by intranasal inoculation with unadapted, influenza virus A/England/42/72, and virus was recovered from nasal washings between 3 and 10 days post-inoculation. Infected animals did not exhibit a febrile response to infection, did not produce local antibody and produced only relatively low levels of serum antibody. However, they developed delayed-type hypersensitivity to influenza virus, demonstrable by both skin tests and macrophage migration inhibition tests, which was similar to that of man. The relevance of the influenza virus specific delayed hypersensitivity in immunity to infection was examined in this model. Guinea pigs previously infected with virus or passively immunized with hyperimmune serum were relatively resistant to reinfection with influenza virus A/England/42/72. Inoculation of guinea pigs with spleen cells from immune donor animals, together with or without immune serum, did not give or enhance resistance to challenge virus infection. The results do not suggest a role for delayed hypersensitivity response in immunity to influenza virus infection.

Evaluation of the efficacy of minocycline therapy for staphylococcal soft-tissue infection.

Ten patients with soft-tissue infections due to Staphylococcus aureus were treated with minocycline, a semisynthetic tetracycline with potent in vitro antistaphylococcal effects. Serum concentrations averaged three to five times the concentration of minocycline required to inhibit growth of S. aureus in vitro. Clearing of the infecting organism was slow (less than 50% of lesions were sterile on day 10 of therapy), but clinical improvement was noted in 8 of 10 patients.

Virulence in Rats of Gentamicin-Carbenicillin-Resistant Pseudomonas

Strains of Pseudomonas aeruginosa, with resistance to gentamicin and carbenicillin which is R factor mediated, showed no alteration in virulence as tested by intraperitoneal injection of rats.

Morton Hamburger (1907-1970): An Appreciation

Morton Hamburger was born August 18, 1907, in Baltimore. He was educated at Johns Hopkins University, receiving his BA in 1928. Under the influence of his uncle, Louis Hamburger, MD, he returned to Hopkins after working abroad for a period and attained his MD degree in 1934. After two years of internship at Lakeside Hospital in Cleveland, he was attracted to Cincinnati by Marion Blankenhorn, MD. Dr. Blankenhorn and his chief resident, Eugene Stead, stimulated Morton Hamburgers interest in careful clinical observation and investigation, which led to a year as research associate at the University of Chicago in the laboratory of O. H. Robertson, MD. There his interest in pneumonia was developed and friendship with Dr. Robertson established which lasted until Dr. Robertsons death in 1966. Dr. Hamburger returned to Cincinnati in 1938 as Dr. Blankenhorns chief resident. His integrity and ability were recognized and the following year he was