John P. Pitman
Centers for Disease Control and Prevention
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Publication
Featured researches published by John P. Pitman.
Vox Sanguinis | 2010
Sridhar V. Basavaraju; Jane Mwangi; J. Nyamongo; Clement Zeh; D. Kimani; Ray W. Shiraishi; R. Madoda; Jully A. Okonji; W. Sugut; S. Ongwae; John P. Pitman; Lawrence H. Marum
Background Following a 1994 study showing a high rate of transfusion‐associated HIV, Kenya implemented WHO blood safety recommendations including: organizing the Kenya National Blood Transfusion Service (NBTS), stringent blood donor selection, and universal screening with fourth‐generation p24 antigen and HIV antibody assays. Here, we estimate the risk of transfusion‐associated HIV transmission in Kenya resulting from NBTS laboratory error and consider the potential safety benefit of instituting pooled nucleic acid testing (NAT) to reduce window period transmission.
Journal of Virological Methods | 2012
Jully A. Okonji; Sridhar V. Basavaraju; Jane Mwangi; Ray W. Shiraishi; Matthew Odera; Kenneth Ouma; John P. Pitman; Lawrence H. Marum; Chin-Yih Ou; Clement Zeh
The World Health Organization recommends screening donor blood for HIV in centralized laboratories. This recommendation contributes to quality, but presents specimen transport challenges for resource-limited settings which may be relieved by using dried blood spots (DBS). In sub-Saharan Africa, most countries screen donor blood with serologic assays only. Interest in window period reduction has led blood services to consider adding HIV nucleic acid testing (NAT). The U.S. Food and Drug Administration (FDA) mandates that HIV-1 NAT blood screening assays have a 95% detection limit at or below 100 copies/ml and 5000 copies/ml for pooled and individual donations, respectively. The Roche COBAS Ampliscreen HIV-1 test, version 1.5, used for screening whole blood or components for transfusion, has not been tested with DBS. We compared COBAS Ampliscreen HIV-1 RNA detection limits in DBS and plasma. An AIDS Clinical Trials Group, Viral Quality Assurance laboratory HIV-1 standard with a known viral load was used to create paired plasma and DBS standard nine member dilution series. Each was tested in 24 replicates with the COBAS Ampliscreen. A probit analysis was conducted to calculate 95% detection limits for plasma and DBS, which were 23.8 copies/ml (95% CI 15.1-51.0) for plasma and 106.7 copies/ml (95% CI 73.8-207.9) for DBS. The COBAS Ampliscreen detection threshold with DBS suggests acceptability for individual donations, but optimization may be required for pooled specimens.
Transfusion | 2015
John P. Pitman; Sridhar V. Basavaraju; Ray W. Shiraishi; Robert Wilkinson; Bjorn von Finckenstein; David W. Lowrance; Anthony A. Marfin; Maarten Postma; Mary Mataranyika; Cees Th. Smit Sibinga
Few African countries separate blood donations into components; however, demand for platelets (PLTs) is increasing as regional capacity to treat causes of thrombocytopenia, including chemotherapy, increases. Namibia introduced single‐donor apheresis PLT collections in 2007 to increase PLT availability while reducing exposure to multiple donors via pooling. This study describes the impact this transition had on PLT availability and safety in Namibia.
Blood Transfusion | 2015
John P. Pitman; Adele Bocking; Robert Wilkinson; Maarten Postma; Sridhar V. Basavaraju; Bjorn von Finckenstein; Mary Mataranyika; Anthony A. Marfin; David W. Lowrance; Cornelis Smit Sibinga
BACKGROUND External assistance can rapidly strengthen health programmes in developing countries, but such funding can also create sustainability challenges. From 2004-2011, the U.S. Presidents Emergency Plan for AIDS Relief (PEPFAR) provided more than
Transfusion Medicine | 2013
Sridhar V. Basavaraju; Britta Lohrke; John P. Pitman; Sonal Pathak; Benjamin P.L. Meza; Ray W. Shiraishi; Robert Wilkinson; Naomi Bock; Mary Mataranyika; David W. Lowrance
8 million to the Blood Transfusion Service of Namibia (NAMBTS) for supplies, equipment, and staff salaries. This analysis describes the impact that support had on actual production costs and the unit prices charged for red cell concentrate (RCC) units issued to public sector hospitals. MATERIAL AND METHODS A costing system developed by NAMBTS to set public sector RCC unit prices was used to describe production costs and unit prices during the period of PEPFAR scale-up (2004-2009) and the 2 years in which PEPFAR support began to decline (2010-2011). Hypothetical production costs were estimated to illustrate differences had PEPFAR support not been available. RESULTS Between 2004-2006, NAMBTS sold 22,575 RCC units to public sector facilities. During this time, RCC unit prices exceeded per unit cost-recovery targets by between 40.3% (US
American Journal of Infection Control | 2017
Runa H. Gokhale; Romeo R. Galang; John P. Pitman; John T. Brooks
16.75 or N
Isbt Science Series | 2014
John P. Pitman; Robert Wilkinson; Sridhar V. Basavaraju; B. von Finckenstein; C. T. Smit Sibinga; Anthony A. Marfin; Maarten Postma; Mary Mataranyika; J.L. Tobias; David W. Lowrance
109.86) and 168.3% (US
information and communication technologies and development | 2009
Stephen Thomas; Adebola Osuntogun; John P. Pitman; Bright Mulenga; Santosh Vempala
48.72 or N
Transfusion Medicine | 2009
Sridhar V. Basavaraju; John P. Pitman; N. Henry; C. McEwan; C. Harry; L. Hasbrouck; L. Marum
333.28) per year. However, revenue surpluses dwindled between 2007 and 2011, the final year of the study period, when NAMBTS sold 20,382 RCC units to public facilities but lost US
Isbt Science Series | 2017
A. Bjork; A. E. Jean Baptiste; E. Noel; N. P. D. Jean Charles; E. Polo; John P. Pitman
23.31 (N