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Dive into the research topics where John P. Pitman is active.

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Featured researches published by John P. Pitman.


Vox Sanguinis | 2010

Reduced risk of transfusion‐transmitted HIV in Kenya through centrally co‐ordinated blood centres, stringent donor selection and effective p24 antigen‐HIV antibody screening

Sridhar V. Basavaraju; Jane Mwangi; J. Nyamongo; Clement Zeh; D. Kimani; Ray W. Shiraishi; R. Madoda; Jully A. Okonji; W. Sugut; S. Ongwae; John P. Pitman; Lawrence H. Marum

Background  Following a 1994 study showing a high rate of transfusion‐associated HIV, Kenya implemented WHO blood safety recommendations including: organizing the Kenya National Blood Transfusion Service (NBTS), stringent blood donor selection, and universal screening with fourth‐generation p24 antigen and HIV antibody assays. Here, we estimate the risk of transfusion‐associated HIV transmission in Kenya resulting from NBTS laboratory error and consider the potential safety benefit of instituting pooled nucleic acid testing (NAT) to reduce window period transmission.


Journal of Virological Methods | 2012

Comparison of HIV-1 detection in plasma specimens and dried blood spots using the Roche COBAS Ampliscreen HIV-1 test in Kisumu, Kenya

Jully A. Okonji; Sridhar V. Basavaraju; Jane Mwangi; Ray W. Shiraishi; Matthew Odera; Kenneth Ouma; John P. Pitman; Lawrence H. Marum; Chin-Yih Ou; Clement Zeh

The World Health Organization recommends screening donor blood for HIV in centralized laboratories. This recommendation contributes to quality, but presents specimen transport challenges for resource-limited settings which may be relieved by using dried blood spots (DBS). In sub-Saharan Africa, most countries screen donor blood with serologic assays only. Interest in window period reduction has led blood services to consider adding HIV nucleic acid testing (NAT). The U.S. Food and Drug Administration (FDA) mandates that HIV-1 NAT blood screening assays have a 95% detection limit at or below 100 copies/ml and 5000 copies/ml for pooled and individual donations, respectively. The Roche COBAS Ampliscreen HIV-1 test, version 1.5, used for screening whole blood or components for transfusion, has not been tested with DBS. We compared COBAS Ampliscreen HIV-1 RNA detection limits in DBS and plasma. An AIDS Clinical Trials Group, Viral Quality Assurance laboratory HIV-1 standard with a known viral load was used to create paired plasma and DBS standard nine member dilution series. Each was tested in 24 replicates with the COBAS Ampliscreen. A probit analysis was conducted to calculate 95% detection limits for plasma and DBS, which were 23.8 copies/ml (95% CI 15.1-51.0) for plasma and 106.7 copies/ml (95% CI 73.8-207.9) for DBS. The COBAS Ampliscreen detection threshold with DBS suggests acceptability for individual donations, but optimization may be required for pooled specimens.


Transfusion | 2015

Namibia's transition from whole blood-derived pooled platelets to single-donor apheresis platelet collections

John P. Pitman; Sridhar V. Basavaraju; Ray W. Shiraishi; Robert Wilkinson; Bjorn von Finckenstein; David W. Lowrance; Anthony A. Marfin; Maarten Postma; Mary Mataranyika; Cees Th. Smit Sibinga

Few African countries separate blood donations into components; however, demand for platelets (PLTs) is increasing as regional capacity to treat causes of thrombocytopenia, including chemotherapy, increases. Namibia introduced single‐donor apheresis PLT collections in 2007 to increase PLT availability while reducing exposure to multiple donors via pooling. This study describes the impact this transition had on PLT availability and safety in Namibia.


Blood Transfusion | 2015

The impact of external donor support through the U.S. President's Emergency Plan for AIDS Relief on the cost of red cell concentrate in Namibia, 2004-2011

John P. Pitman; Adele Bocking; Robert Wilkinson; Maarten Postma; Sridhar V. Basavaraju; Bjorn von Finckenstein; Mary Mataranyika; Anthony A. Marfin; David W. Lowrance; Cornelis Smit Sibinga

BACKGROUND External assistance can rapidly strengthen health programmes in developing countries, but such funding can also create sustainability challenges. From 2004-2011, the U.S. Presidents Emergency Plan for AIDS Relief (PEPFAR) provided more than


Transfusion Medicine | 2013

Knowledge and barriers related to reporting of acute transfusion reactions among healthcare workers in Namibia

Sridhar V. Basavaraju; Britta Lohrke; John P. Pitman; Sonal Pathak; Benjamin P.L. Meza; Ray W. Shiraishi; Robert Wilkinson; Naomi Bock; Mary Mataranyika; David W. Lowrance

8 million to the Blood Transfusion Service of Namibia (NAMBTS) for supplies, equipment, and staff salaries. This analysis describes the impact that support had on actual production costs and the unit prices charged for red cell concentrate (RCC) units issued to public sector hospitals. MATERIAL AND METHODS A costing system developed by NAMBTS to set public sector RCC unit prices was used to describe production costs and unit prices during the period of PEPFAR scale-up (2004-2009) and the 2 years in which PEPFAR support began to decline (2010-2011). Hypothetical production costs were estimated to illustrate differences had PEPFAR support not been available. RESULTS Between 2004-2006, NAMBTS sold 22,575 RCC units to public sector facilities. During this time, RCC unit prices exceeded per unit cost-recovery targets by between 40.3% (US


American Journal of Infection Control | 2017

A tale of 2 HIV outbreaks caused by unsafe injections in Cambodia and the United States, 2014-2015

Runa H. Gokhale; Romeo R. Galang; John P. Pitman; John T. Brooks

16.75 or N


Isbt Science Series | 2014

Investments in blood safety improve the availability of blood to underserved areas in a sub-Saharan African country.

John P. Pitman; Robert Wilkinson; Sridhar V. Basavaraju; B. von Finckenstein; C. T. Smit Sibinga; Anthony A. Marfin; Maarten Postma; Mary Mataranyika; J.L. Tobias; David W. Lowrance

109.86) and 168.3% (US


information and communication technologies and development | 2009

Design and deployment of a blood safety monitoring tool

Stephen Thomas; Adebola Osuntogun; John P. Pitman; Bright Mulenga; Santosh Vempala

48.72 or N


Transfusion Medicine | 2009

The need for computerized tracking systems for resource-limited settings: the example of Georgetown, Guyana.

Sridhar V. Basavaraju; John P. Pitman; N. Henry; C. McEwan; C. Harry; L. Hasbrouck; L. Marum

333.28) per year. However, revenue surpluses dwindled between 2007 and 2011, the final year of the study period, when NAMBTS sold 20,382 RCC units to public facilities but lost US


Isbt Science Series | 2017

Geographic distribution of blood collections in Haiti before and after the 2010 earthquake

A. Bjork; A. E. Jean Baptiste; E. Noel; N. P. D. Jean Charles; E. Polo; John P. Pitman

23.31 (N

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Sridhar V. Basavaraju

Centers for Disease Control and Prevention

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Ray W. Shiraishi

Centers for Disease Control and Prevention

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David W. Lowrance

Centers for Disease Control and Prevention

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Anthony A. Marfin

Centers for Disease Control and Prevention

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Clement Zeh

Centers for Disease Control and Prevention

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Jane Mwangi

Centers for Disease Control and Prevention

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Lawrence H. Marum

Centers for Disease Control and Prevention

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Adebola Osuntogun

Georgia Institute of Technology

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Benjamin P.L. Meza

Centers for Disease Control and Prevention

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