John P. Wyatt

Panlobular and Centrilobular Emphysema: Correlation of Clinical Findings with Pathologic Patterns

Excerpt Two distinct types of pulmonary emphysema have been recognized by post-mortem examination of the lungs by macrosection technics. Seventy-five such cases (39 centrilobular, 36 panlobular) ha...

EVOLUTION OF ENDOMETRIAL CARCINOMA STUDIED BY SEQUENTIAL CURETTINGS

ENDOMETRIAL cancer is pre-eminently a maiignant disease beginning at the menopause or late in the fourth decade of life (Pack and Le Fevre, 1930). Previous reports of endometrial cancer in girls under 19 years of age have been documented by Hirst (1929), Hertig and Sommers (1949), and Ladinski (1915) Case 15. The example previously presented by Taussig (1925) probably represents an instance of exaggerated hyperplasia. The single report (Adams, 1916) of endometrial carcinoma in a 24-year-old girl probably illustrates an example of mixed mesodermal tumour with dominance of epithelial development. Because of this rarity, the documentation of the following case is of value. Furthermore, tracing the development of fundic carcinoma through sequential curettings is of even greater significance, as the biopsy material offers morphological evidence of the biological steps leading to the ultimate development of endometrial cancer.

The Acute Toxicity of Reactor Polyphenyls on the Lung

Mice were exposed to an aerosol of a polyphenyl reactor coolant for several hours daily up to eight days. The oil concentration was comparable to that measured in the atmosphere at the reactor site. No evidence of lung injury was detected by light microscopy. At the ultrastructural level, many type 2 alveolar epithelial cells showed central vacuolation of mitochondria. These ceils exhibited the normal turnover time of around 35 days. Following the cessation of aerosol exposure, the succeeding generation of epithelial cells showed no abnormality.

RADIATION SURVIVAL: IMPROVED RATES FOLLOWING CHLORTETRACYCLINE ADMINISTRATION.

Oral administration of chlortetracycline to mice before and after 1100 rads whole body x-irradiation resulted in a substantially enhanced survival rate (88%) over nontreated animals. This occurred in spite of severe pancytopenia as illustrated by the depression of marrow DNA and leukocyte values. Antibiotic administration solely in the preirradiation or postirradiation periods produced a smaller increase in survival (56%). The results are attributed to the control of endogenous and exogenous bacterial infection before and after irradiation rather than a radioprotective effect.

“Chronic Obstructive Lung Disease”: Syndrome of Clinical Expediency

Careful antemortem appraisal and pathologic investigations on a whole-lung basis can bring about significant advances in understanding of chronic pulmonary disease. With this approach, omnibus terms such as “obstructive lung syndrome,” “asthma and emphysema,” and “chronic irreversible lung disease” can be eliminated and the etiologic and pathogenic factors in these disparate forms of disease elucidated.