John R. Lindsay
University of Chicago
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Featured researches published by John R. Lindsay.
Annals of Otology, Rhinology, and Laryngology | 1976
Fumiro Suga; John R. Lindsay
Temporal bone histopathology of 17 aged patients who had spontaneous and gradually progressive bilateral sensorineural hearing losses associated with aging was studied. Six cases in the present material showed the gradually sloping audiometric curve; nine cases, abrupt high tone hearing loss; and two cases, the flat audiometric curve. The most prominent histopathological change in the inner ear was a decrease in the population of the spiral ganglion cells. However, diffuse senile atrophy was also often seen in the organ of Corti and the stria vascularis. A positive correlation between the degree of arteriosclerosis and the degree of sensorineural degeneration in the cochlea was not obtained in the present cases. Also, the correlation was not found to be consistent between the type of the audiometric curve and the localization of lesions in the sensory, the neural or the vascular elements in the cochlea. Our observations show that a certain type of audiometric curve does not necessarily indicate a lesion in a specific cochlear element.
Acta Oto-laryngologica | 1958
John R. Lindsay; Gustav K. von Schulthess
The clinical picture and the histological findings in a case of hydrops endolymphaticus cochleae is given. The case is remarkable because of an unusual degeneration of the first neurons in the apical turn of the right ear. There is also a beginning hydrops in the apical turn of the opposite ear. Neither clinically nor histologically could signs of a vestibular dysfunction be found. The findings are discussed.
Acta Oto-laryngologica | 1963
Henry B. Perlman; Michio Tsunoo; Alex Spence; John R. Lindsay
Normal values for blood flow velocity in some terminal vascular units of the cochlea (stria vascularis and spiral ligament) and for carotid blood pressure are presented along with the percentage changes produced by administration of epinephrine, norepinephrine, vasopressin and serotonin. Increases in flow velocity in these cochlear vessels can be produced. These are closely related to the measured increases in mean carotid blood pressure. Cochlear function as measured by the microphonic response to a moderate acoustic stimulus is not altered by this increase in cochlear blood flow. Some general relations between flow velocity, oxygen utilization and cell function are discussed.
Annals of Otology, Rhinology, and Laryngology | 1972
Joan T. Zajtchuk; Gregory J. Matz; John R. Lindsay
The etiology of hcrpes oticus was first postulated by Hunt1 after reviewing the excellent pathological work of Head and Campbell on spinal herpes zoster.2 Hunt attributed the pathology of herpes oticus to the geniculate ganglion. In his specimen the pars intermedius was degenerated and by the proximity of the geniculate ganglion to this sensory root, he concluded that the geniculate ganglion was the site of the pathology although this structure was avulsed at the time of the dissection.
Annals of Otology, Rhinology, and Laryngology | 1976
Naomi Fitch; John R. Lindsay; Herbert Srolovitz
Histological study of the temporal bones of an infant with the preauricular pit, cervical fistula, hearing loss syndrome revealed abnormalities in the middle ear, the vestibular system, and the cochlea. There is a gross bilateral abnormality in the form and relationship of the middle ear spaces, the middle cranial fossa and the inner ear. The horizontal canal lacks ampulla and crista; the posterior canal terminates a short distance from the ampulla. The cochlear cavity is approximately four fifths of normal size. The modiolus of the cochlea shows minor abnormalities. Spiral ganglion cells and peripheral nerve fibers are present in all coils, but are below normal in population in the basal and apical coils. The stria vascularis is slightly deformed and partly atrophic in the upper apical coil. An occasional concretion is present in the base of the stria vascularis in the middle and apical coils.
Annals of Otology, Rhinology, and Laryngology | 1976
Fumiro Suga; John R. Lindsay
The temporal bones of three cases of acoustic neurinoma are described to illustrate histopathological features of inner ear lesions due to chronic partial obstruction of blood circulation by the tumor in the internal auditory meatus. Degenerative changes in the inner ear due to acoustic neurinoma were evaluated and compared with changes in the opposite ear. The main pathological findings in the inner ear which were attributed to the tumor were degeneration of nerve fibers and of ganglion cells, degeneration of the stria vascularis, degeneration of the tectorial membrane, fibrosis and ossification of a semicircular canal. Fairly good preservation of sensory cells was observed in the presence of total degeneration of nerve fibers and ganglion cells and subtotal degeneration of the stria vascularis.
Annals of Otology, Rhinology, and Laryngology | 1979
Leonard R. Proctor; John R. Lindsay; H. B. Perlman; Gregory J. Matz
A case of herpes zoster oticus is presented in which the lateral and superior semicircular canals of the labyrinth were affected unilaterally. The results of several electronystagmographic examinations are described and correlated with the patients description of symptoms. This case study indicates that disease affecting the lateral semicircular canal is reliably detected by the conventional caloric test. However, the fact that the posterior semicircular canal remained intact could not be inferred from the results of the caloric test in this case. Also, the appearance of nystagmus upon eye closure appears to have been a more sensitive index of the state of the disease process than was the caloric test.
Annals of Otology, Rhinology, and Laryngology | 1966
John R. Lindsay; David D. Beal
There were 2 ears with a small focus of otosclerosis at the border of the round window membrane only, without any obstruction of the niche and with no other foci in the temporal bone. There were two cases from each of which only one ear has been processed with a single large focus of otosclerosis at the attachment of the round window membrane, with obstruction of the niche estimated at about eighty per cent.
Annals of Otology, Rhinology, and Laryngology | 1979
Robert I. Kohut; John R. Lindsay
The histologic findings in a serially sectioned temporal bone, from a patient who succumbed to brain abscess secondary to necrotizing (“malignant”) external otitis, are described. The mechanism of invasion of the ear canal appears to be due to local bone necrosis. This in turn extends to the submucosal vasculature of the pneumatic spaces. The infective process extends submucosally, establishing one or several sites of bone destruction. The lumen of the pneumatic space is not involved. In this process, the periphery of the fibrous inflammatory tissue formation is the site of active bone destruction. In pneumococcal petrositis, the peripheral fibrous elements are protective. The process in malignant external otitis may extend directly to adjacent central nervous system structures inoculating the structure with Pseudomonas. Development of Pseudomonas brain abscesses can be slow, allowing for new bone closure of the site from which the infection spreads as demonstrated in this specimen. Therefore, apparent local control of the disease can be established while a central infective process progresses.
Annals of Otology, Rhinology, and Laryngology | 1975
Joan T. Zajtchuk; John R. Lindsay
The temporal bone report of an operated case of osteogenesis imperfecta tarda is presented. Histological examination confirmed the presence of bilateral fixation of the footplate by otosclerosis as the cause of the conductive hearing loss. Fragility of bony septae in the mastoid and of the stapedial crura were observed. Sensorineural impairment in later years with a reduction in neural elements in the cochlea appear related to the extent and activity of the otosclerotic foci. Additional temporal bone reports of three cases of osteogenesis imperfecta congenita show lack of deposition of the skein-like bone in the endochondral layer, sparse bony septae in marrow spaces and deficiency of the periosteal layer. The stapedial crura were thin and in two cases both were deformed and fractured.