John S. Lawrence

THE DYNAMICS OF LEUKOPENIA AND LEUKOCYTOSIS

Excerpt Many features of the physiology of leukocytes are controversial. The origin of certain cells—for example, the monocyte and the plasma cell—is disputed. The functions of many of the cell spe...

Antisera to neutrophils, lymph node cells, and thymus cells of the guinea pig: hematological effects and antibody localization.

SUMMARY The hematological and the immunological studies of antincutrophilicserum(ANS),and antilymphocytic serum(ALS) show remarkable agreement. Thus,ANS produces its significant effects on stabs and neytrophils whereas ATS has a distinct effect on stabs and neutriphils and, also a very distinct effect on the lymphcyts. ALS produces a significant reduction in blood and marrow neutrophils. Precipitating antibodies to neutrophil antigens are present in both ANS and ATS. No precipitating antibodies have been demonstrable in and about Hassalls corpuseles by immunofluorescent technique. The findings may be of importance in the interpretation of certain experimental results dealing with immunosuppression by means of antisera for white blood cells.