John W. Blunt

Review: Marine natural products

Covering: 2010. Previous review: Nat. Prod. Rep., 2011, 28, 196. This review covers the literature published in 2010 for marine natural products, with 895 citations (590 for the period January to December 2010) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1003 for 2010), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

Chapter 8:1H-NMR Spectroscopy: The Method of Choice for the Dereplication of Natural Product Extracts

The rapid dereplication (assessment of novelty) of crude extracts is an essential part of all natural product discovery programs. 1H-NMR data collection is now practicable at the nanomolar scale, opening the way to 1H-NMR-based dereplication approaches. In this chapter, the applicability of 1H-NMR-based approaches to dereplication is described using examples of dereplication strategy based on available NMR-oriented databases.