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Tetrahedron Letters | 1996

Investigation of an unusual rearrangement

David Bernard Smith; Todd R. Elworthy; David J. Morgans; Janis T. Nelson; John W. Patterson; Alfredo Vasquez; Ann Marie Waltos

Abstract An unusual rearrangement of allyl phenyl ethers 3 related to mycophenolic acid has been investigated. The intramolecularity of the rearrangement has been established via a crossover experiment.


Journal of Medicinal Chemistry | 1996

Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase by nuclear variants of mycophenolic acid.

Peter H. Nelson; Stephen F. Carr; Bruce H. Devens; Elsie M. Eugui; Fidencio Franco; Carlos Gonzalez; Ronald Charles Hawley; David G. Loughhead; David J. Milan; Eva Papp; John W. Patterson; Sussan Rouhafza; Eric Brian Sjogren; David Bernard Smith; Rebecca A. Stephenson; Francisco Xavier Talamas; Ann-Marie Waltos; Robert James Weikert; John C. Wu


Archive | 1995

5-substituted derivatives of mycophenolic acid

David J. Morgans; David Bernard Smith; Francisco Xavier Talamas; Dean R. Artis; Alicia Cervantes; Todd R. Elworthy; Mario Fernandez; Fidencio Franco; Ronald Charles Hawley; Teresa Lara; David G. Loughhead; Peter H. Nelson; John W. Patterson; John C. Rohloff; Eric Brian Sjogren; Alejandra Trejo; Ann Marie Waltos; Robert James Weikert


Archive | 2004

Enzyme inhibition immunoassay

Mitali Ghoshal; Gerald Sigler; Raymond A. Hui; Ronald Charles Hawley; Eva Hoess; Erasmus J. Huber; John W. Patterson; Salvatore J. Salamone; Allan Dorn


Journal of Medicinal Chemistry | 1992

3-Carboxy-5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide, a new prodrug for the antiarthritic agent 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide.

John W. Patterson; Paul S. Cheung; Michael J. Ernest


Archive | 1995

6-substituted mycophenolic acid and derivatives

John W. Patterson; David J. Morgans; David Bernard Smith; Francisco Xavier Talamas; Dean R. Artis; Alicia Cervantes; Todd R. Elworthy; Mario Fernandez; Fidencio Franco; Ronald Charles Hawley; Teresa Lara; David G. Loughhead; Peter H. Nelson; Eric Brian Sjogren; Alejandra Trejo; Ann Marie Waltos; Robert James Weikert


Archive | 1990

4-isoxazolecarboxamide derivatives

John W. Patterson; Bruce H. Devens


Journal of Medicinal Chemistry | 1984

Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines.

Klaus K. Weinhardt; Colin C. Beard; Charles Alois Dvorak; Michael Marx; John W. Patterson; Adolph P. Roszkowski; Margery Schuler; Stefan H. Unger; Paul J. Wagner; Marshall B. Wallach


Archive | 1995

4-AMINO DERIVATIVES OF 5-SUBSTITUTED MYCOPHENOLIC ACID

David J. Morgans; Eric Brian Sjogren; David Bernard Smith; Francisco X. Talam as; Dean R. Artis; Alicia Cervantes; Todd R. Elworthy; Mario Fern andez; Fidencio Franco; Ronald Charles Hawley; Teresa Lara; David G. Loughhead; Peter H. Nelson; John W. Patterson; Alejandra Trejo; Ann Marie Waltos; Robert James Weikert


Archive | 2003

Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase

Mitali Ghoshal; Gerald Sigler; Raymond A. Hui; Ronald Charles Hawley; Eva Hoess; Erasmus J. Huber; John W. Patterson; Salvatore J. Salamone; Allan R. Dorn

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