John W. Remington

Effect of Progesterone and Other Hormones on Liver Glycogen.

Summary Progesterone as well as cortical extract raised the liver glycogen levels of intact fasting ferrets. Pseudopregnancy probably enhanced the effectiveness of progesterone. In a small number of rats cortical extracts had similar effects, while progesterone, testosterone propionate and stilboestrol gave little if any response.

Low-iodine goiter and the resistance of the rat to thyreotropic stimulation.

Summary 1. Normal rats receiving pituitary stimulation showed a slight positive thyroid response, as determined by differences in fresh weight, dry matter content, iodine content, and histological picture. 2. Rats with hyperplastic goiters, produced by an iodine-deficient diet, were just as resistant to pituitary stimulation as were the normals, 3. Iodine administration at a level which will just protect the normal rat against thyroid hyperplasia does not affect this resistance. 4. On the basis of the criteria used, the low-iodine hyperplastic goiter seems to differ from the reported spontaneous goiter, in that it does not alter the natural resistance of the rat to thyrotropic stimulation.