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Dive into the research topics where Jolanta Pajewska is active.

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Featured researches published by Jolanta Pajewska.


New Journal of Chemistry | 2003

Replacing proline at the apex of heptapeptide-based chloride ion transporters alters their properties and their ionophoretic efficacy

Paul H. Schlesinger; Riccardo Ferdani; Jolanta Pajewska; Robert Pajewski; George W. Gokel

A membrane anchored heptapeptide, (C18H37)2NHCOCH2OCH2CO–NH–Gly–Gly–Gly–Pro–Gly–Gly–Gly–OCH2Ph, has proved to be a selective chloride anion transporter that functions in phospholipid bilayer membranes. When Pro was replaced by the natural amino acid Leu, the activity decreased dramatically. In the present study, Pro is replaced by pipecolic acid (homoproline, Pip); the resulting anchored heptapeptide is a membrane active, chloride selective transporter.


New Journal of Chemistry | 2007

The effect of midpolar regime mimics on anion transport mediated by amphiphilic heptapeptides

Robert Pajewski; Jolanta Pajewska; Ruiqiong Li; Megan M. Daschbach; Elizabeth A. Fowler; George W. Gokel

Nine amphiphilic heptapeptides, synthetic anion transporters (SATs) of the form (C18H37)2N–Y–(Gly)3-Pro-(Gly)3–OCH2Ph were prepared. The unit (OH2)Y represents the diacids succinic, glutaric, diglycolic, 3-thiaglutaric, N-methyliminodiglycine, isophthalic, and terephthalic acids. Additionally, Y was absent or present as acetic acid affording the structure (C18H37)2N–(Gly)3-Pro-(Gly)3–OCH2Ph or (C18H37)2N–(Gly)4-Pro-(Gly)3–OCH2Ph. The diglycolic acid derivative was reported previously but the remaining compounds are new. These nine peptides mediated release of Cl– from DOPC/DOPA vesicles with varying efficacy. Chloride release diminished for the Y-containing amphiphilic heptapeptides in the order glutaric, succinic > 3-thiaglutaric > terephthalic > acetic, N-methyliminodiacetic, > no Y, isophthalic. The release of Cl– was generally exponential over time but the curve shapes were distinctly sigmoidal for the more flexible diacids. Computational studies were undertaken to assess differences in conformation. Overall, it appeared that Cl– release for those SATs that could adopt a linear conformation on the N-terminal side of proline correlated best with the polarity of the diacid.


Chemical Communications | 2003

Anchor chain length alters the apparent mechanism of chloride channel function in SCMTR derivatives.

Paul H. Schlesinger; Natasha Djedovič; Riccardo Ferdani; Jolanta Pajewska; Robert Pajewski; George W. Gokel

Two membrane-anchored heptapeptides have been prepared and their pore-formation behavior in phospholipid bilayer membranes has been found to differ profoundly as a result only of alkyl chain length.


Chemical Communications | 2006

Glycine position permutations and peptide length alterations change the aggregation state and efficacy of ion-conducting, pore-forming amphiphiles

Riccardo Ferdani; Robert Pajewski; Jolanta Pajewska; Paul H. Schlesinger; George W. Gokel

Changes in the peptide chain of amphiphilic heptapeptides known to form ion-conducting pores in bilayers dramatically alter transport efficacy and the aggregation number of pore formation.


Chemical Communications | 2003

The C-terminal ester of membrane anchored peptide ion channels affects anion transport.

Natasha Djedovič; Riccardo Ferdani; Egan Harder; Jolanta Pajewska; Robert Pajewski; Paul H. Schlesinger; George W. Gokel

Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.


Chemical Communications | 2002

A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes

Paul H. Schlesinger; Riccardo Ferdani; Robert Pajewski; Jolanta Pajewska; George W. Gokel

The heptapeptide sequence Gly-Gly-Gly-Pro-Gly-Gly-Gly, when anchored to diglycolic acid derived (C18H37)2NCOCH2OCH2COOH, forms chloride-selective ion channels in phospholipid liposomes but the related heptapeptide Gly-Gly-Gly-Leu-Gly-Gly-Gly, and tripeptide Gly-Gly-Gly do not.


Journal of Inclusion Phenomena and Macrocyclic Chemistry | 2001

Solid-State Evidence for Alkali Metal to Arene Pi-Complexation

Riccardo Ferdani; Jiaxin Hu; W. Matthew Leevy; Jolanta Pajewska; Robert Pajewski; Victor Barbour; Leonard J. Barbour; George W. Gokel

We report a variety of alkali metal cation-π interactions, documented by X-ray crystallography. These include interactions with the neutral arenes benzene, phenol, and indole. We also include structural results for lithium, sodium, potassium, rubidium, and cesium cation-π complexes in which the arene has enhanced electron richness owing to an adjacent or integral charge.


Journal of the American Chemical Society | 2002

SCMTR: A Chloride-Selective, Membrane-Anchored Peptide Channel that Exhibits Voltage Gating

Paul H. Schlesinger; Riccardo Ferdani; Jun Liu; Jolanta Pajewska; Robert Pajewski; Mitsuyoshi Saito; Hossein Shabany; George W. Gokel


New Journal of Chemistry | 2005

The C-and N-terminal residues of synthetic heptapeptide ion channels influence transport efficacy through phospholipid bilayers

Natasha Djedovič; Riccardo Ferdani; Egan Harder; Jolanta Pajewska; Robert Pajewski; Michelle E. Weber; Paul H. Schlesinger; George W. Gokel


Bioorganic & Medicinal Chemistry | 2004

Functional, synthetic organic chemical models of cellular ion channels.

George W. Gokel; Paul H. Schlesinger; Natasha Djedovič; Riccardo Ferdani; Egan Harder; Jiaxin Hu; W. Matthew Leevy; Jolanta Pajewska; Robert Pajewski; Michelle E. Weber

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George W. Gokel

University of Missouri–St. Louis

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Robert Pajewski

Washington University in St. Louis

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Riccardo Ferdani

Washington University in St. Louis

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Paul H. Schlesinger

Washington University in St. Louis

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Natasha Djedovič

Washington University in St. Louis

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Egan Harder

Washington University in St. Louis

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Ruiqiong Li

Washington University in St. Louis

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Jiaxin Hu

Washington University in St. Louis

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Michelle E. Weber

Washington University in St. Louis

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W. Matthew Leevy

Washington University in St. Louis

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