Jon Come
Scripps Research Institute
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Publication
Featured researches published by Jon Come.
Journal of Medicinal Chemistry | 2015
Philip N. Collier; David Messersmith; Arnaud Le Tiran; Upul K. Bandarage; Christina Boucher; Jon Come; Kevin M. Cottrell; Veronique Damagnez; John D. Doran; James P. Griffith; Suvarna Khare-Pandit; Elaine Krueger; Mark Ledeboer; Brian Ledford; Yusheng Liao; Sudipta Mahajan; Cameron Stuver Moody; Setu Roday; Tiansheng Wang; Jinwang Xu; Alex Aronov
A series of high affinity second-generation thiazolopiperidine inhibitors of PI3Kγ were designed based on some general observations around lipid kinase structure. Optimization of the alkylimidazole group led to inhibitors with higher levels of PI3Kγ selectivity. Additional insights into PI3K isoform selectivity related to sequence differences in a known distal hydrophobic pocket are also described.
Nucleosides, Nucleotides & Nucleic Acids | 1994
Robert Chen; Michael G. Goodman; Dennis C. Argentieri; Stanley C. Bell; Levelle E. Burr; Jon Come; Jacquelyn H. Goodman; Dieter H. Klaubert; Bruce E. Maryanoff; Barbara L. Pope; Marianne S. Rampulla; Mary R. Schott; Allen Reitz
Abstract 7-Allyl-8-oxoguanosine (loxoribine, 5) was selected from a series of guanosine derivatives for further evaluation as an immunostimulant. Numerous related analogs were also synthesized and evaluated: 2′,3′-ketals of 5 are particularly interesting because they are active, apparently without being cleaved to the free nucleoside.
Journal of Medicinal Chemistry | 1994
Allen B. Reitz; Michael G. Goodman; Barbara L. Pope; Dennis C. Argentieri; Stanley C. Bell; Levelle E. Burr; Erika Chourmouzis; Jon Come; Jacquelyn H. Goodman
Archive | 2003
Upul K. Bandarage; Jon Come; Emanuele Perola; Govinda Rao Bhisetti; Jeffrey O. Saundres
Archive | 2017
Albert Pierce; Alex Aronov; Amaud Le Tiran; Anne Laure Grillot; David Messersmith; Elaine Krueger; Hardwin O'dowd; James A. Henderson; Jian Wang; Jingrong Cao; Jon Come; Philip N. Collier; Robert J. Davies; Ronald Grey; Suganthini Nanthakumar; Upul K. Bandarage; Yusheng Liao
Archive | 2010
Alex Aronov; Jon Come; Robert J. Davies; Albert Pierce; Jian Wang; Suganthini Nanthakumar; Jingrong Cao; Upul K. Bandarage; Elaine Krueger; Amaud Le Tiran; Yusheng Liao; David Messersmith; Philip N. Collier; Ronald Grey; Hardwin O'dowd; James A. Henderson; Anne-Laure Grillot
Archive | 2008
Albert Pierce; Jon Come; John J. Court; Huai Gao; Gregory Henkel; Michael Liu; Timothy Neuberger
Archive | 2007
Jeremy Green; Jingrong Cao; Upul K. Bandarage; Jon Come; Craig Marhefka
Archive | 2007
Jeremy Green; Jingrong Cao; Upul K. Bandarage; Jon Come; Craig Marhefka
Archive | 2007
Upul K. Bandarage; Jingrong Cao; Jon Come; Jeremy Green; Craig Marhefka
Collaboration
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