Jon K. Linderman
Ames Research Center
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Featured researches published by Jon K. Linderman.
Life Sciences | 1996
Jon K. Linderman; Robert J. Talmadge; K. L. Gosselink; Phuong N. Tri; Roland R. Roy; R. E. Grindeland
The purpose of this study was to investigate whether the soleus muscle undergoes atrophy and alterations in myosin heavy chain (MHC) composition during non-weight bearing in the absence of synergists. Thirty-two female rats were randomly assigned to four groups: control (C), synergistic ablation (ABL) of the gastrocnemius and plantaris muscles to overload the soleus muscle, hindlimb suspension (HLS), or a combination of synergistic ablation and hindlimb suspension (HLS-ABL). After 28 days of hindlimb suspension, soleus atrophy was more pronounced in HLS (58%) than in HLS-ABL (43%) rats. Compared to C rats, non-weight bearing decreased mixed and myofibrillar protein contents and Type I MHC 49%, 45%, and 7%, respectively, in HLS animals. In addition, de novo expression of fast Type IIx and Type IIb MHC (5% and 2%, respectively) was observed in HLS animals. Similarly, when compared to C rats, mixed and myofibrillar protein contents and Type I MHC decreased 43%, 46%, and 4%, respectively, in HLS-ABL animals. Also, de novo expression of Type IIx (4%) and IIb (1%) MHC was observed. Collectively, these data indicate that the loss of muscle protein and Type I MHC, and the de novo expression of Type IIx and Type IIb MHC in the rat soleus occur independently of the presence of synergists during non-weight bearing. Furthermore, these results confirm the contention that soleus mass and MHC expression are highly sensitive to alterations in mechanical load.
Journal of Applied Physiology | 1997
David L. Allen; Jon K. Linderman; Roland R. Roy; R. E. Grindeland; Venkat R. Mukku; V. R. Edgerton
Journal of Applied Physiology | 1998
Gary E. McCall; David L. Allen; Jon K. Linderman; R. E. Grindeland; Roland R. Roy; Venkat R. Mukku; V. R. Edgerton
American Journal of Physiology-regulatory Integrative and Comparative Physiology | 1994
Jon K. Linderman; K. L. Gosselink; F. W. Booth; V. R. Mukku; R. E. Grindeland
Journal of Applied Physiology | 2002
Eduard Jose-Cunilleras; Kenneth W. Hinchcliff; Richard A. Sams; Steven T. Devor; Jon K. Linderman
Sports Medicine | 1994
Jon K. Linderman; K. L. Gosselink
Journal of Sports Science and Medicine | 2005
Timothy J. Demchak; Jon K. Linderman; W. Jerry Mysiw; Rebecca D. Jackson; Jihong Suun; Steven T. Devor
Life Sciences | 1995
Jon K. Linderman; Justen B. Whittall; K. L. Gosselink; Tommy J. Wang; Venkat R. Mukku; Frank W. Booth; R. E. Grindeland
Archive | 1992
Frank W. Booth; Jon K. Linderman; Christopher R. Kirby
Archive | 2015
V. Reggie Edgerton; David L. Allen; Jon K. Linderman; Roland R. Roy; R. E. Grindeland