Jon Sassin

Human prolactin - 24-hour pattern with increased release during sleep.

Human prolactin was measured in plasma by radioimmunoassay at 20 minute intervals for a 24-hour period in each of six normal adults, whose sleep-wake cycles were monitored polygraphically. A marked diurnal variation in plasma concentrations was demonstrated, with highest values during sleep; periods of episodic release occurred throughout the 24 hours.

The temporal relation between high release and sleep stage changes at nocturnal sleep onset in man

Abstract The temporal pattern of growth hormone release at sleep onset was studied in six adult human subjects by frequent blood sampling combined with polygraphic sleep recording. HGH release was associated with sleep onset but not with the transition from waking to sleep. Delta activity consistently preceded the first elevation of plasma HGH.

Reduction of growth hormone secretion following clomiphene administration

Abstract Serial plasma growth hormone (GH) concentrations were measured every 20 min for 24 hr before and after the administration of clomiphene citrate (100 mg/day for 7 days) to four healthy young adult male subjects. The number of GH secretory episodes and the magnitude of the peak plasma concentrations during both wakefulness and sleep were decreased after the clomiphene treatment periods.