Jonas Sode

Plasma testosterone, luteinizing hormone, and follicle-stimulating hormone after vasectomy.

Plasma testosterone, LH, and FSH were measured in 24 healthy subjects prior to and after bilateral vasectomy. No significant changes were noted in any of the hormones 42 and 87 days after surgery; this indicated that normal testicular function persisted during the period of study.

Cessation of growth hormone secretion associated with acute elevation of the serum-free fatty acid concentration☆

Abstract Following the intravenous injection of fat (Intralipid) with heparin into five unanesthetized adult male baboons, the serum FFA level rose to a mean (±SE) of 11.30 ± 3.58 meq/liter at 5 min and the serum GH concentration fell rapidly from a mean base-line value of 8.1 ± 2.0 ng/ml to 3.4 ± 1.4 ng/ml 20 min after injection (T12 = 19 min. This fall in serum GH was more consistent and of greater magnitude than that following the injection of either fat or heparin alone. A late rise in GH was not observed through 2 hr. The depression of serum GH was not explicable on the basis of hyperglycemia. The rapid fall in the serum GH concentration after the injection of fat with heparin, with a serum halftime approximating the disappearance rate of GH in man, the consistent temporal relationship between fat with heparin injection and the fall in GH concentration, and the failure of either fat or heparin alone to consistently produce similar serum GH patterns suggest that the injection of fat with heparin with acute elevation of serum FFA concentrations to supraphysiologic levels caused virtual cessation of GH secretion. Thus, free fatty acids, in addition to glucose and amino acids, may be involved in the regulation of GH secretion.

The effect of sedation and awakening on energy substrates and hormonal relationships in the subhuman primate

Abstract Fifteen adult baboons were tranquilized with 1-(1-phenylcyclohexyl) piperidine hydrochloride (Sernylan) early in the morning and changes in hormonal levels and energy substrates were determined as the animal awoke. Serum-free fatty acids and plasma cortisol rose during the 4-hr observation period. This was accompanied by a similar rise in urinary catecholamines and 11-hydroxycorticosteroids. An elevation in serum glucose and a decrease in serum insulin were observed but these changes did not achieve statistical significance. Serum growth hormone decreased during the experimental period. These changes are discussed in relation to the use of the awake baboon for experimental shock studies.

Immunochemical and physiologic insulin lack during lethal E. coli septicemia in the subhuman primate.

Depressed insulin secretion is a feature of severe stress, and it is usually, though not invariably, associated with hypotension. Absolute hypoinsulinemia develops during experimental hemorrhagic hypotension (5, 18) and experimental gram-negative septicemia (7) in the baboon. In man, investigators have observed relative hypoinsulinemia after combat trauma (4) and impaired serum insulin responses to intravenous glucose or tolbutamide after acute myocardial infarction (1, 2, 6, 23). After cranial trauma, the serum insulin response to intravenous glucose may be impaired (14).