Jonathan D. Low | Researchain

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Featured researches published by Jonathan D. Low.

Archive | 2011

Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer

Michael D. Bartberger; Ana Gonzalez Buenrostro; Hilary P. Beck; Xiaoqi Chen; Richard V. Connors; Jeffrey Deignan; Jason Duquette; John Eksterowicz; Benjamin Fisher; Brian M. Fox; Jiasheng Fu; Zice Fu; Felix Gonzalez-Lopez de Turiso; Michael W. Gribble; Darin Gustin; Julie Anne Heath; Xin Huang; Xianyun Jiao; Michael G. Johnson; Frank Kayser; David J. Kopecky; SuJen Lai; Yihong Li; Zhihong Li; Jiwen Liu; Jonathan D. Low; Brian Lucas; Zhihua Ma; Lawrence R. McGee; Joel McIntosh

Archive | 2011

Amino -dihydrooxazine and amino - dihydrothiazine spiro compounds as beta - secretase modulators and their medical use

Jian J. Chen; Wenge Zhong; Bryant Yang; Wenyuan Qian; Patricia Lopez; Ryan White; Matthew Weiss; Ted Judd; Timothy Powers; Yuan Cheng; Thomas Dineen; Oleg Epstein; Jonathan D. Low; Isaac E. Marx; Ana Elena Minatti; Nick A. Paras; Michele Potashman

Archive | 2014

PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

Ana Elena Minatti; Jonathan D. Low; Jennifer R. Allen; Jian Chen; Ning Chen; Yuan Cheng; Ted Judd; Qingyian Liu; Patricia Lopez; Wenyuan Qian; Shannon Rumfelt; Robert M. Rzasa; Nuria A. Tamayo; Qiufen Xue; Bryant Yang; Wenge Zhong

Archive | 2014

Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use

Ana Elena Minatti; Jonathan D. Low; Jennifer R. Allen; Albert Amegadzie; James Brown; Michael J. Frohn; Angel Guzman-Perez; Paul E. Harrington; Patricia Lopez; Vu Van Ma; Nobuko Nishimura; Wenyuan Qian; Shannon Rumfelt; Robert M. Rzasa; Kelvin Sham; Adrian L. Smith; Ryan White; Qiufen Xue

Archive | 2011

Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use

Ana Elena Minatti; Oleg Epstein; Ryan White; Matthew Weiss; Wenge Zhong; Jonathan D. Low

Archive | 2015

Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use

Jennifer R. Allen; Albert Amegadzie; Matthew P. Bourbeau; James Brown; Jian J. Chen; Yuan Cheng; Michael J. Frohn; Angel Guzman-Perez; Paul E. Harrington; Longbin Liu; Qingyian Liu; Jonathan D. Low; Vu Van Ma; James Manning; Ana Elena Minatti; Thomas Nguyen; Nobuko Nishimura; Mark H. Norman; Liping H. Pettus; Alexander J. Pickrell; Wenyuan Qian; Shannon Rumfelt; Robert M. Rzasa; Aaron C. Siegmund; Markian Stec; Ryan White; Qiufen Xue

Bioorganic & Medicinal Chemistry Letters | 2018

Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine beta-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation.

Jonathan D. Low; Bartberger; Yuan Cheng; Douglas A. Whittington; Qiufen Xue; Stephen Wood; Jennifer R. Allen; Ana Elena Minatti

MedChemComm | 2017

Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D

Jonathan D. Low; Michael D. Bartberger; Kui Chen; Yuan Cheng; Mark R. Fielden; Vijay Keshav Gore; Dean Hickman; Qingyian Liu; E. Allen Sickmier; Hugo M. Vargas; Jonathan A. Werner; Ryan White; Douglas A. Whittington; Stephen Wood; Ana Elena Minatti

Archive | 2016

COMPUESTOS DE TIAZIN-2-AMINA FUSIONADOS CON CICLOPROPILO COMO INHIBIDORES DE BETA-SECRETASA Y MÉTODOS DE USO

Qiufen Xue; Ryan White; Markian Stec; Aaron C. Siegmund; Robert M. Rzasa; Shannon Rumfelt; Wenyuan Qian; Alexander J. Pickrell; Liping H. Pettus; Mark H. Norman; Nobuko Nishimura; Thomas Nguyen; Ana Elena Minatti; James Manning; Vu Van Ma; Jonathan D. Low; Qingyian Liu; Longbin Liu; Paul Harrington; Angel Guzman-Perez; Michael J. Frohn; Yuan Cheng; Jian J. Chen; James Brown; Matthew P. Bourbeau; Albert Kudzovi Amegadzie; Jennifer R. Allen

Archive | 2015

Composés thiazin-2-amine fusionnée à un groupement cyclopropyle utilisés en tant qu'inhibiteurs de la bêta-secrétase et leurs procédés d'utilisation

Jennifer R. Allen; Albert Kudzovi Amegadzie; Matthew P. Bourbeau; James Brown; Jian J. Chen; Yuan Cheng; Michael J. Frohn; Angel Guzman-Perez; Paul Harrington; Longbin Liu; Qingyian Liu; Jonathan D. Low; Vu Van Ma; James Manning; Ana Elena Minatti; Thomas Nguyen; Nobuko Nishmura; Mark H. Norman; Liping H. Pettus; Alexander J. Pickrell; Wenyuan Qian; Shannon Rumfelt; Robert M. Rzasa; Aaron C. Siegmund; Markian Stec; Ryan White; Qiufen Xue

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