Jonathan F. Cohen

Cyanide antidotes for mass casualties: Water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration

Current cyanide antidotes are administered by IV infusion, which is suboptimal for mass casualties. Therefore, in a cyanide disaster, intramuscular (IM) injectable antidotes would be more appropriate. We report the discovery of the highly water-soluble sulfanegen triethanolamine as a promising lead for development as an IM injectable cyanide antidote.

The Asymptotic Behaviour of the Maximum Likelihood Estimates for Univariate Extremes

Let F be in the domain of attraction of the type I extreme value distribution. The behaviour of the maximum likelihood estimates when fitting the incorrect model Λ(ax+b) to the distribution of the maximum Fn(x) is investigated. The main result is that under widely applicable conditions, the estimated distribution function is consistent for an optimal type I distribution in the sense of [3] and that the parameter estimates of a and b are asymptotically normal. Some of the implications for statistical inference problems are discussed. Finally, similar results for the case where three-parameter extreme-value approximations are fitted are hypothesized. On this basis we give some general conclusions on the problem of choice of extrema model for Fn(x).