Jonathan Gardner

Nut Consumption in Pregnancy May Increase Asthma Risk in Child

Early childhood colonization with the major human commensal microbe Helicobacter pylori may be protective against asthma, study findings show. According to the “hygiene hypothesis,” the rise in asthma and allergic disorders that occurred during the 20th century relates to a reduction in exposure to environmental antigens and alterations in gut microbiota during development of the immune system. Changes in human colonization with H. pylori represent a “biologically plausible” candidate in the hygiene hypothesis, asserted Dr. Yu Chen of New York University and Dr. Martin J. Blaser of New York University and the Veterans Affairs Medical Center, New York.. The investigators explained that there has been a near universal association of this organism and humans for at least 58,000 years, since the time of the initial human migration out of Africa. Seropositivity is generally acquired during the first few years of life and remains lifelong unless eradicated by antibiotics. The prevalence of seropositivity began to decline early in the last century, a trend that was paralleled by an increase in asthma. Today the seroprevalence in native-born children younger than 10 years in the United States stands at less than 10%, wrote the researchers ( J. Infect. Dis. 2008;198: 553-60). To investigate whether this decline in H. pylori colonization could be linked to the increase in asthma in children, the investigators analyzed data from the National Health and Nutrition Examination Survey (NHANES) 1999-2000, which is a representative sample of the U.S. population. They estimated odds ratios for asthma, wheezing, and other allergic conditions such as allergic rhinitis and eczema, with adjustment for age, body mass index, smoking, education level, race, country of origin, and also for antibiotic and corticosteroid use in the previous month, medical insurance status, and household income. The sample included 7,412 participants, 3,327 of whom were younger than 20 years. Overall seroprevalence for H. pylori was 26%, but prevalence was lower in younger groups, with only 5% of children younger than 10 years being seropositive. For the entire cohort there was a trend toward an inverse association between seropositivity for H. pylori and ever having had asthma and for having had one or more asthma attacks during the past year. There was a significant inverse association between H. pylori seropositivity and having had eczema or dermatitis in the past year, with an odds ratio of 0.73. Among the 3,327 subjects who were age 19 years or younger at the time of data collection, there was a strong inverse association between H. pylori positivity and onset of asthma before 5 years of age, with an odds ratio of 0.58. Furthermore, among those aged 3-13 years, strong inverse associations were seen for seropositivity and current asthma, ever having had asthma, and having had allergic rhinitis during the previous year. A possible explanation for the recent decline in H. pylori colonization is the widespread use of antibiotics in children for conditions such as otitis media, according to Dr. Chen and Dr. Blaser. In fact, they noted, their study population was “strongly impacted” by antibiotics, with 11% of those younger than 10 years having had an antibiotic during the month before data collection. Eradication rates of H. pylori with antibiotic monotherapy range from 10% to 50%. “Our findings suggest H. pylori status is one of the measurable risk factors for asthma and atopic conditions in children,” they wrote. Among the characteristics favoring H. pylori as protective is its dominance in the gastric microbiota and its “intimate relationship with the gastric mucosa, where it injects bacterial constituents into epithelial cells.” In seropositive subjects, lymphoid cells such as helper and regulatory T cells are found in the gastric lamina propria. These lymphoid cell populations are absent in seronegative persons. Dr. Chen and Dr. Blaser commented that the loss of the lymphoid compartment in the stomach, with its activator and regulatory T cells, could potentially lower an agedependent threshold for allergic sensitization. ■

Hormonal Precursor Could Make Dx of Sepsis Easier

G L A S G O W, S C O T L A N D — Swiss researchers have identified a hormonal precursor that may make it easier for physicians to identify patients suffering from sepsis, according to a study presented at the 8th European Congress of Endocrinology. The substance is copeptin, a precursor to vasopressin, which is produced when the body undergoes stress, such as septic shock. Vasopressin is unstable and has a short half-life, making it difficult to use in identifying patients who are suffering from sepsis. Copeptin, on the other hand, is more stable and is derived from the same precursor molecule. A team of researchers from the departments of endocrinology and internal medicine at University Hospital, Basel, Switzerland, led by Dr. Mirjam Christ-Crain, evaluated 101 consecutive critically ill patients over a 9-month period and compared their relative serum copeptin levels with relative copeptin levels in 50 healthy control subjects. Copeptin levels were measured at admission, day 2, and hospital discharge or death. Copeptin levels were identified in the blood using a test that will soon be available commercially from the German medical equipment manufacturer Brahms AG. Of the 101 critically ill patients, 53 had sepsis, severe sepsis, or septic shock; 48 had systemic inflammatory response syndrome (SIRS). At admission, patients with SIRS had a median copeptin level of 27.6 pmol/L of blood, those with sepsis 50 pmol/L, those with severe sepsis 73.6 pmol/L, and those with septic shock 171.5 pmol/L. In comparison, healthy controls had a median copeptin level of 5 pmol/L, Dr. ChristCrain said. Patients with sepsis, severe sepsis, or septic shock who died had median copeptin blood levels of 171.5 pmol/L, compared with 86.8 pmol/L among those who survived. Septicemia is the 10th-leading cause of death in the United States, claiming 33,464 lives in 2004, according to the Centers for Disease Control and Prevention. “Copeptin is a novel tool to assess the prognosis of sepsis,” Dr. Christ-Crain observed. “It might help to guide the resource allocation of hospital care to those patients especially in need for intensive surveillance.” ■ Ju n e 1 , 2 0 0 6 • w w w. f a m i l y p r a c t i c e n ew s . c o m Infectious Diseases 31