Jonathan Rushton

Zoonosis emergence linked to agricultural intensification and environmental change

A systematic review was conducted by a multidisciplinary team to analyze qualitatively best available scientific evidence on the effect of agricultural intensification and environmental changes on the risk of zoonoses for which there are epidemiological interactions between wildlife and livestock. The study found several examples in which agricultural intensification and/or environmental change were associated with an increased risk of zoonotic disease emergence, driven by the impact of an expanding human population and changing human behavior on the environment. We conclude that the rate of future zoonotic disease emergence or reemergence will be closely linked to the evolution of the agriculture–environment nexus. However, available research inadequately addresses the complexity and interrelatedness of environmental, biological, economic, and social dimensions of zoonotic pathogen emergence, which significantly limits our ability to predict, prevent, and respond to zoonotic disease emergence.

Impact of avian influenza outbreaks in the poultry sectors of five South East Asian countries (Cambodia, Indonesia, Lao PDR, Thailand, Viet Nam) outbreak costs, responses and potential long term control

Highly pathogenic avian influenza (HPAI), in most cases the strain H5N1, was known to be present in all countries of this study in 2003 and was officially reported by all countries in January 2004 (OIE, 2005; FAO, 2004). The outbreak appears to be most widely spread in Indonesia, Thailand and Viet Nam, with the latter two countries also reporting human cases and fatalities (FAO, 2005). The importance of this disease is a combination of:

The economics of animal health and production.

1. What Is Economics And How Is It Useful? 2. Livestock Production Economics 3. Economics Of Controlling Livestock Diseases: Basic Theory 4. Data Collection 5. Different Methods Of Livestock Data Collection Methods 6. Economic Analysis Tools 7. Modelling And The Generation Of Information 8. Optimisation Methods For Assisting Policy Decisions On Endemic Diseases 9. Tools That Going Beyond The Enterprise Farm Or Business Level 10. Tools For Assessing The Price And Market Impacts Of Livestock Policies 11. The New Institutional Economics And The Assessment Of Animal Disease Control 12. Social And Culture Factors 13. The Economics Of Zoonoses And Their Control 14. Livestock Populations And Production Systems 15. The Main Livestock Diseases 16. Diseases Of Large Ruminants 17. Diseases Of Small Ruminants 18. Diseases Of Pigs 19. Diseases Of Poultry 20. Livestock Policy And Poverty Reduction - Experiences From The Developing World 21. Economics In Animal Health Policy Making In Northern Ireland 22. Animal Diseases Management In A New Livestock Trade Environment: The Case Of Chile 23. Decision Making, Scales And Quality Of Economic Evaluations For The Control Of Contagious Bovine Pleuropneumonia (CBPP) 24. Animal Health Policy In South Asia: What Can Economic Analysis Contribute 25. Approaches To Economic Analyses And Implications For Policy Issues In South East Asia Results From Three Case Studies In Crop - Animal Systems.

Towards a conceptual framework to support one-health research for policy on emerging zoonoses.

Summary In the past two decades there has been a growing realisation that the livestock sector was in a process of change, resulting from an expansion of intensive animal production systems and trade to meet a globalised worlds increasing demand for livestock products. One unintended consequence has been the emergence and spread of transboundary animal diseases and, more specifically, the resurgence and emergence of zoonotic diseases. Concurrent with changes in the livestock sector, contact with wildlife has increased. This development has increased the risk of transmission of infections from wildlife to human beings and livestock. Two overarching questions arise with respect to the real and perceived threat from emerging infectious diseases: why are these problems arising with increasing frequency, and how should we manage and control them? A clear conceptual research framework can provide a guide to ensure a research strategy that coherently links to the overarching goals of policy makers. We propose such a new framework in support of a research and policy-generation strategy to help to address the challenges posed by emerging zoonoses.

Hanging in, Stepping Up and Stepping Out: Livelihood Aspirations and Strategies of the Poor

In recent years understanding of poverty and of ways in which people escape from or fall into poverty has become more holistic. This should improve the capabilities of policy analysts and others working to reduce poverty, but it also makes analysis more complex. This article describes a simple schema which integrates multi-dimensional, multi-level, and dynamic understandings of poverty, of poor peoples livelihoods, and of changing roles of agricultural systems. The article suggests three broad types of strategy pursued by poor people: ‘hanging in’, ‘stepping up’, and ‘stepping out’. This simple schema explicitly recognises the dynamic aspirations of poor people, diversity among them, and livelihood diversification. It also brings together aspirations of poor people with wider sectoral, inter-sectoral, and macro-economic questions about policies necessary for the realisation of those aspirations.

Feeding the world healthily: the challenge of measuring the effects of agriculture on health

Agricultural production, food systems and population health are intimately linked. While there is a strong evidence base to inform our knowledge of what constitutes a healthy human diet, we know little about actual food production or consumption in many populations and how developments in the food and agricultural system will affect dietary intake patterns and health. The paucity of information on food production and consumption is arguably most acute in low- and middle-income countries, where it is most urgently needed to monitor levels of under-nutrition, the health impacts of rapid dietary transition and the increasing ‘double burden’ of nutrition-related disease. Food availability statistics based on food commodity production data are currently widely used as a proxy measure of national-level food consumption, but using data from the UK and Mexico we highlight the potential pitfalls of this approach. Despite limited resources for data collection, better systems of measurement are possible. Important drivers to improve collection systems may include efforts to meet international development goals and partnership with the private sector. A clearer understanding of the links between the agriculture and food system and population health will ensure that health becomes a critical driver of agricultural change.

Industrial Food Animal Production and Global Health Risks: Exploring the Ecosystems and Economics of Avian Influenza

Many emerging infectious diseases in human populations are associated with zoonotic origins. Attention has often focused on wild animal reservoirs, but most zoonotic pathogens of recent concern to human health either originate in, or are transferred to, human populations from domesticated animals raised for human consumption. Thus, the ecological context of emerging infectious disease comprises two overlapping ecosystems: the natural habitats and populations of wild animals, and the anthropogenically controlled habitats and populations of domesticated species. Intensive food animal production systems and their associated value chains dominate in developed countries and are increasingly important in developing countries. These systems are characterized by large numbers of animals being raised in confinement with high throughput and rapid turnover. Although not typically recognized as such, industrial food animal production generates unique ecosystems—environments that may facilitate the evolution of zoonotic pathogens and their transmission to human populations. It is often assumed that confined food animal production reduces risks of emerging zoonotic diseases. This article provides evidence suggesting that these industrial systems may increase animal and public health risks unless there is recognition of the specific biosecurity and biocontainment challenges of the industrial model. Moreover, the economic drivers and constraints faced by the industry and its participants must be fully understood in order to inform preventative policy. In order to more effectively reduce zoonotic disease risk from industrial food animal production, private incentives for the implementation of biosecurity must align with public health interests.

Impacts of avian influenza virus on animal production in developing countries

This paper reviews the (predominantly grey) literature on impacts of highly pathogenic avian influenza (HPAI) strain H5N1 and control responses on the livestock sector and associated industries in developing countries. The authors distinguish between impacts that arise directly through HPAI-related morbidity and mortality, those that are a consequence of public intervention to control or eradicate HPAI, and impacts that are mediated through market reactions. The paper further considers how these impacts propagate up- and downstream through related supply and distribution networks, how short-term reactions are followed by longer-term adjustments, how impacts include direct cost elements and foregone income, and why losses to the poultry sector will, at least to some extent, be ‘passed on’ on the one hand, for example through compensation, and, on the other hand, be compensated for by gains in other livestock subsectors. Differences in methodology applied in the reviewed reports result in a lack of comparability of estimates for HPAI ‘costs/impacts’ across countries and even within countries and are compounded by information deficits. Despite these shortcomings, the literature permits some significant conclusions to be drawn on the relative importance of direct and indirect impacts and on their distribution across different types of poultry producers. The paper ends by outlining directions of future research that combine epidemiology and economics to provide a framework for disease control decisionmaking.

Cost of post-weaning multi-systemic wasting syndrome and porcine circovirus type-2 subclinical infection in England - An economic disease model

Post-weaning multi-systemic wasting syndrome (PMWS) is a multi-factorial disease with major economic implications for the pig industry worldwide. The present study aimed to assess the economic impact of PMWS and porcine circovirus type 2 (PCV2) subclinical infections (PCV2SI) for farrow-to-finish farms and to estimate the resulting cost to the English pig industry. A disease model was built to simulate the varying proportions of pigs in a batch that get infected with PCV2 and develop either PMWS, subclinical disease (reduce growth without evident clinical signs) or remain healthy (normal growth and no clinical signs), depending on the farm level PMWS severity. This PMWS severity measure accounted for the level of post-weaning mortality, PMWS morbidity and proportion of PCV2 infected pigs observed on farms. The model generated six outcomes: infected pigs with PMWS that die (PMWS-D); infected pigs with PMWS that recover (PMWS-R); subclinical pigs that die (Sub-D); subclinical pigs that reach slaughter age (Sub-S); healthy pigs sold (H-S); and pigs, infected or non-infected by PCV2, that die due to non-PCV2 related causes (nonPCV2-D). Enterprise and partial budget analyses were used to assess the deficit/profits and the extra costs/extra benefits of a change in disease status, respectively. Results from the economic analysis at pig level were combined with the disease models estimates of the proportion of different pigs produced at different severity scores to assess the cost of PMWS and subclinical disease at farm level, and these were then extrapolated to estimate costs at national level. The net profit for a H-S pig was £19.2. The mean loss for a PMWS-D pig was £84.1 (90% CI: 79.6–89.1), £24.5 (90% CI: 15.1–35.4) for a PMWS-R pig, £82.3 (90% CI: 78.1–87.5) for a Sub-D pig, and £8.1 (90% CI: 2.18–15.1) for a Sub-S pig. At farm level, the greatest proportion of negative economic impact was attributed to PCV2 subclinical pigs. The economic impact for the English pig industry for the year 2008, prior to the introduction of PCV2 vaccines, was estimated at £52.6 million per year (90% CI: 34.7–72.0), and approximately £88 million per year during the epidemic period. This was the first study to use empirical data to model the cost of PMWS/PCV2SI at different farm severity levels. Results from this model will be used to assess the efficiency of different control measures and to provide a decision support tool to farmers and policy makers.

A Blueprint to Evaluate One Health

One Health (OH) positions health professionals as agents for change and provides a platform to manage determinants of health that are often not comprehensively captured in medicine or public health alone. However, due to the organization of societies and disciplines, and the sectoral allocation of resources, the development of transdisciplinary approaches requires effort and perseverance. Therefore, there is a need to provide evidence on the added value of OH for governments, researchers, funding bodies, and stakeholders. This paper outlines a conceptual framework of what OH approaches can encompass and the added values they can provide. The framework was developed during a workshop conducted by the “Network for Evaluation of One Health,” an Action funded by the European Cooperation in Science and Technology. By systematically describing the various aspects of OH, we provide the basis for measuring and monitoring the integration of disciplines, sectors, and stakeholders in health initiatives. The framework identifies the social, economic, and environmental drivers leading to integrated approaches to health and illustrates how these evoke characteristic OH operations, i.e., thinking, planning, and working, and require supporting infrastructures to allow learning, sharing, and systemic organization. It also describes the OH outcomes (i.e., sustainability, health and welfare, interspecies equity and stewardship, effectiveness, and efficiency), which are not possible to obtain through sectoral approaches alone, and their alignment with aspects of sustainable development based on society, environment, and economy.