Jonathan S. Baum

Diazotransfer Reactions with p-Acetamidobenzenesulfonyl Azide

Abstract The utility of p-acetamidobenzenesulfonyl azide in diazotransfer reactions is described. This practical, cost effective reagent offers advantages over existing alternatives.

Structural replacements for the benzoxazinone protox inhibitors

Substituted benzoxazinones are a class of highly active inhibitors of protoporphyrinogen oxidase (protox) which are effective at controlling grass and broadleaf weeds at low rates. As part of the process of optimization of the herbicidal activity of the 6-heterocyclic benzoxazinones, a number of replacements were prepared for the oxazinone ring. Quantitative structure-activity relationships (QSAR) were developed for the benzoxazinone replacements using molecular properties, and these were compared to published QSAR for the acyclic 2,4,5-trisubstituted arylheterocyclic protox inhibitors. That the molecular properties of the acyclic and bicyclic protox inhibitors are similar suggest they may be interacting with the same binding site.

Synthesis of 2-Aryl-3-cyanophthalimidines and Related Analogs

Abstract A series of novel 3-cyano- and related 3-substituted phthalmidines have been synthesized from acyclic precursors, some of which were isolated.