Jong Hee Park
Pusan National University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Jong Hee Park.
Archives of Pharmacal Research | 1998
So Young Kang; Sang Hyun Sung; Jong Hee Park; Young Choong Kim
Scopoletin (7-hydroxy-6-methoxycoumarin), a coumarin, was isolated from the aerial part ofSolanum lyratum Thunb. by the activity-guided fractionation employing carbon tetrachloride-intoxicated primary cultured rat hepatocytes as a screening system. Its hepatoprotective activity was first evaluated by measuring the release of glutamic pyruvic transaminase and sorbitol dehydrogenase from carbon tetrachloride-intoxicated rat hepatocytes into the culture medium. Scopoletin significantly reduced the releases of glutamic pyruvic transaminase and sorbitol dehydrogenase from the carbon tetrachloride-intoxicated primary cultured rat hepatocytes by 53% and 58%, respectively, from the toxicity in a dose-dependent manner over concentration ranges of 1 μM to 50 μM. Further studies revealed that at the concentration of 10 μM, scopoletin significantly preserved glutathione content by 50% and the activity of superoxide dismutase by 36% and also inhibited the production of malondialdehyde to the degree as seen in the control.
Archives of Pharmacal Research | 2004
Jeong Seon Yoon; Sang Hyun Sung; Jong Hee Park; Young Choong Kim
Two pterocarpans [(6aR,11aR)-maackiain, (6aR,11aR)-medicarpin], one flavanone [(2S)-7-hydroxy-6-methoxy-flavanone], one isoflavan (sativan) and two isoflavones (pseudobaptige-nin, genistein) were isolated from theSpatholobus suberectus (Leguminosae). Their chemical structures were determined by comparison of their spectroscopic parameters of CD, EIMS, 1D-NMR and 2D-NMR with those reported in the literatures. All of these compounds are reported for the first time from this plant through the present study.
Archives of Pharmacal Research | 2011
Myung-Hoe Kim; Agung Nugroho; Jongwon Choi; Jong Hee Park; Hee-Juhn Park
To identify an analgesic/anti-inflammatory component from the leaves of Rhododendron aureum (Ericaceae), phytochemical isolation and pharmacological assays (writhing assays and vascular permeability assay for analgesic action in mice; carrageenan-induced paw edemaand TPA-induced ear edema assays of anti-inflammatory action in rats) were performed. Four compounds were isolated from the active fraction (BuOH fraction) by silica gel column chromatography and identified as (−)-rhododendrol, (−)-rhododendrin, avicularin and hyperoside by spectroscopic methods. Rhododendrin, the main compound of the BuOH fraction, exhibited significant analgesic actions in mice and anti-inflammatory actions in rats. This compound accounted for 3.1% of the MeOH extract and 0.48% of dried leaves, respectively, on HPLC analysis. These results suggest that rhododendrin is the major biologically active substance in the leaves of R. aureum with analgesic/anti-inflammatory activity.
Archives of Pharmacal Research | 1989
Byeng Wha Son; Jong Hee Park; Ok-Pyo Zee
Catechin and catechin glycoside named uldavioside A were isolated from the Korean folk medicineUlmus davidiana. Based on chemical and physicochemical evidences, their structure have been determined as (+)-catechin (1) and (+)-catechin-5-O-β-D-apiofuranoside (2).
Archives of Pharmacal Research | 1990
Jae Sue Choi; Won Sick Woo; Han Suk Young; Jong Hee Park
From the stem ofPrunus davidiana, naringenin and its glucoside, kaempferol and its glucoside, dihydrokaempferol, kaempferide glucoside, hesperetin glucoside, quercetin glucoside, d-catechin and β-sitosterol glucoside were isolated.
Archives of Pharmacal Research | 1989
Han Suk Young; Jong Hee Park; Hee Juhn Park; Jae Sue Choi
From the stem ofCudrania tricuspidata, β-sitosterol, β-sitosterol glucoside, arthocarpesin, norarthocarpetin, and 5-O-methyl genistein were isolated and characterized by spectral data.
Biological & Pharmaceutical Bulletin | 2003
Byung-Soo Koo; Kyung-Su Park; Jeoung-Hee Ha; Jong Hee Park; Jae-Chul Lim; Dong-Ung Lee
Planta Medica | 2005
Kyung Ah Koo; Sang Hyun Sung; Jong Hee Park; Seung-Hyun Kim; Ki Yong Lee; Young Choong Kim
Chemical & Pharmaceutical Bulletin | 2005
Jae-Chul Lim; Jong Hee Park; Milos Budesinsky; Alexander Kasal; Yeong Hwan Han; Byung Soo Koo; Seung Il Lee; Dong Ung Lee
Biological & Pharmaceutical Bulletin | 2002
Sang Hyun Sung; So Young Kang; Ki Yong Lee; Mi Jung Park; Jeong Hun Kim; Jong Hee Park; Young Chul Kim; Jinwoong Kim; Young Choong Kim