Jong-Lyel Roh

Sclerotherapy for Congenital Lesions in the Head and Neck

OBJECTIVES: This study retrospectively reviews the results of sclerotherapy using several sclerosants for congenital lesions of the head and neck. METHODS AND PATIENTS: Between May 1990 and May 2002, patients with lymphatic malformations were treated by sclerotherapy; 10 with bleomycin, and 25 with OK-432. OK-432 sclerotherapy was also applied in 9 patients with plunging ranula and in 1 patient with branchial anomaly. Percutaneous sclerotherapy with ethanolamine oleate was used in 29 patients with venous malformations, and 28 patients with pyriform sinus fistula were treated by trichloroacetic acid chemocauterization. RESULTS: Overall, two thirds of patients with these lesions showed marked to complete response. One case of mortality occurred in the bleomycin sclerotherapy group. However, no major complications by other sclerosants were found. In lymphatic malformations, history of excision before sclerotherapy was a poor prognostic factor. CONCLUSION: Sclerotherapy using these sclerosants is a safe and effective primary treatment for congenital lesions in the head and neck.

Xerostomia Following Radiotherapy of the Head and Neck Affects Vocal Function

PURPOSEnTo investigate whether xerostomia induced by wide-field radiotherapy (RT) of the head and neck affects vocal function.nnnPATIENTS AND METHODSnWe conducted a retrospective cohort study comparing 20 patients with early glottic cancer treated by limited RT of the larynx to 20 patients receiving wide-field RT of the primary tumor site and the lymphatic system of the entire head and neck, including the salivary glands. Salivary and vocal functions, as well as responses to questionnaires on xerostomia and quality of life were compared between groups. Twenty healthy volunteers matched for age, sex, and smoking status were included as controls.nnnRESULTSnThe wide-field RT patients showed high xerostomia-related symptom scores and significantly lower values of whole salivary flow rate compared to the limited RT and healthy patients (P < .001). Subjective vocal dysfunction and stroboscopic abnormality were observed in the wide-field RT group (P < .05), but acoustic or aerodynamic profiles showed no significant difference among groups (P > .05). Subjective and objective salivary gland hypofunction was significantly correlated to vocal dysfunction.nnnCONCLUSIONnOur results suggest that xerostomia following extensive RT of the head and neck can affect vocal function. In the treatment of head and neck malignancies, efforts to prevent post-RT xerostomia would be anticipated to contribute to the preservation of vocal function.

Retroauricular hairline incision for removal of upper neck masses.

Background/Objectives: The general population has been increasingly concerned about cosmesis and hopeless about prominent or invisible postoperative scars of the face and neck. The purpose of this study was to evaluate the benefit of a retroauricular hairline incision (RAHI) by comparing it with conventional cervical incision for removal of upper neck masses.

Prevention of Anterior Glottic Stenosis after Transoral Microresection of Glottic Lesions Involving the Anterior Commissure with Mitomycin C

Objective: To evaluate the effectiveness of topical mitomycin C (MMC) in preventing anterior glottic stenosis (AGS) after transoral microresection of glottic lesions involving the anterior commissure (AC).

Intrathyroid hemorrhage and acute upper airway obstruction after fine needle aspiration of the thyroid gland.

Objectives: Although hematoma formation after fine needle aspiration (FNA) is the most commonly encountered complication, massive intrathyroid hemorrhage producing acute upper airway obstruction rarely occurs.

Bile Acid Induces Cyclo-Oxygenase-2 Expression in Cultured Human Pharyngeal Cells: A Possible Mechanism of Carcinogenesis in the Upper Aerodigestive Tract by Laryngopharyngeal Reflux†

Objectives/Hypothesis Laryngopharyngeal reflux is a common event in patients with head and neck cancer. Bile acid is known to be related to tumor formation in the esophagus through the overexpression of cyclo‐oxygenase‐2 (COX‐2), an enzyme that produces prostanoids. To better understand the mechanism of the laryngopharyngeal reflux–cancer connection, we examined COX‐2 expression by bile acid in cultured human pharyngeal mucosa cells.

Primary Treatment of Ranula With Intracystic Injection of OK-432

Objective: Although surgery is the first choice of therapy for ranula, it was made a hypothesis that ranula can be primarily treated with sclerotherapy from prior evidence. This study examined the effectiveness of intracystic injection of OK‐432 for treatment of ranula.

The Utility of Second‐Look Operation After Laser Microresection of Glottic Carcinoma Involving the Anterior Commissure

Objectives/Hypothesis: Transoral laser microsurgery for the treatment of glottic carcinoma with anterior commissure (A‐com) involvement is associated with a high rate of recurrence. We prospectively evaluated the outcomes of laser microsurgery and the efficacy of second‐look operation in these patients.

OK-432 Sclerotherapy of Cervical Chylous Lymphocele After Neck Dissection

Backgound/Objectives: Postoperative cervical chylous lymphoceles are extremely rare circumscribed collections of lymph which are usually treated by drainage or surgical exploration, but rarely by sclerotherapy. We investigated the efficacy of OK‐432 (Picibanil, Chungai Pharmaceutical Co., Tokyo, Japan) sclerotherapy in the treatment of cervical lymphocele after neck dissection.

Küttner's tumor: Unusual presentation with bilateral involvement of the lacrimal and submandibular glands

Chronic sclerosing sialadenitis, known as Küttners tumor (KT), is a chronic inflammatory disease of the salivary gland characterized by progressive periductal fibrosis, dilated ducts with a dense lymphocyte infiltration and lymphoid follicle formation, and acinar atropy. We report a unique case of KT in a 30-year-old female who presented with time-serial involvement of the bilateral lacrimal and submandibular glands with reactive follicular hyperplasia of bilateral upper cervical lymph nodes. All tissue samples of the submandibular and lacrimal glands were typical of KT on pathologic examination. There was no evidence of lymphoepithelial lesions or intraepithelial lymphocytes. This is the first case of KT involving both lacrimal and submandibular glands, suggesting that KT is closely related to an active local immune process.