Joong Hyup Kim

Syntheses and evaluation of pyrido[2,3-d]pyrimidine-2,4-diones as PDE 4 inhibitors

The syntheses and in vitro evaluation of a new series of pyrido[2,3-d]pyrimidine-2,4-diones bearing substituents at C-3 and/or C-4 positions on the pyridine ring are described. Some of these compounds, especially 51 and 6f, were found to be potent phosphodiesterase 4 (PDE 4) inhibitors exhibiting improved ratio of PDE 4 inhibitory activity:rolipram binding assay (RBA).

Mild and Efficient Reduction of Sulfoxides to Sulfides with Titanium Tetrachloride–Indium System

Abstract TiCl4/In system was found to be a new reagent for reducing various sulfoxides to the corresponding sulfides in good yields under mild conditions.

Synthesis and structure–activity relationships of quaternary ammonium cephalosporins with 3-pyrazolylpyridinium derivatives

Cephalosporins with 3-pyazolylpyridinium at C-3 position, which is supposed to exhibit synergic activity of ceftazidime and cefoselis, were synthesized and their antibacterial activity against gram-positive and gram-negative was inspected.

MILD AND EFFICIENT REDUCTION OF SULFOXIDES TO SULFIDES WITH BIS-(CYCLOPENTADIENYL)TITANIUM(IV) DICHLORIDE–INDIUM SYSTEM

ABSTRACT Cp2TiCl2/In system was found to be a new reagent for reducing various sulfoxides to the corresponding sulfides in good yields under mild and neutral conditions.

Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)amino]methyl cephalosporin derivatives

The new cephalosporins having N-linked quarternary ammonium salt at C-3 position were prepared from the reaction of 2-methylimino-3-methyl-1,3-thiazoline derivatives with cephalosporins. Also antimicrobial activities of those compounds were determined.

Facile Deoxygenation of Amine‐N‐oxides With CoCl2 · 6H2O–Indium System

Abstract CoCl2 · 6H2O/In system was found to be a new reagent for deoxygenation of various amine‐N‐oxides to the corresponding amines in good to excellent yields under sonication.

Indium-mediated coupling of bromoacetonitriles with aromatic acyl cyanides: convenient synthesis of aromatic α-cyano ketones

Indium-mediated coupling of bromoacetonitrile and 2-bromopropionitrile with a variety of aromatic acyl cyanides afforded the corresponding aromatic α-cyano ketones in moderate to good yields under mild and neutral conditions.

A facile reduction of aromatic nitro compounds to aromatic amines with bis(cyclopentadienyl)titanium(IV) dichloride-indium system

ABSTRACT Cp2TiCl2/In system was found to be a new reagent for reducing various aromatic nitro compounds to the corresponding aromatic amines in good yields under mild and neutral conditions.

Indium-mediated reductive coupling of acyl cyanides: a convenient synthesis of 1,2-diketones

Abstract The indium-mediated reductive coupling of acyl cyanides afforded the corresponding 1,2-diketones in moderate to good yields under neutral and mild conditions.

Synthesis and Biological Evaluation of Novel Apio Nucleosides with Thiazole‐4‐carboxamide and 1,2,4‐Triazole‐3‐carboxamide

In view of biological activities of azole nucleosides and apio‐dideoxynucleoside, novel apio nucleoside analogues (1 and 2) with thiazole and triazole base moiety were synthesized using 2,3‐O‐isopropylidene‐apio‐β‐d‐furanose (3), which was prepared from d‐mannose.