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Dive into the research topics where Joost Alexander Kolkman is active.

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Featured researches published by Joost Alexander Kolkman.


Drug Discovery Today: Technologies | 2010

Nanobodies – from llamas to therapeutic proteins

Joost Alexander Kolkman; Debbie A. Law

Antibodies have been a focus of drug development since the approval of Orthoclone® OKT3 in 1986. However these large biologics are not without limitations. This has led to new technologies which harness the power of the immune system but provide distinct advantages over conventional antibody approaches. Nanobodies® are llama-derived proteins with unique characteristics well suited for drug discovery. The Nanobody platform has proven robust with four Nanobodies currently in clinical development.


Archive | 2007

Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling

Joost Alexander Kolkman; Els Beirnaert


Archive | 2007

Peptides capable of binding to serum proteins

Hilde Revets; Joost Alexander Kolkman; Hendricus Renerus Jacobus Mattheus Hoogenboom


Archive | 2007

DP-78-Like Nanobodies

Joost Alexander Kolkman


Archive | 2007

Polypeptides specific for complexes involved in receptor-mediated signaling, such as the il-6/il-6 receptor complex

Els Beirnaert; Joost Alexander Kolkman; Hendricus Renerus Jacobus Matteus Hoogenboom


Archive | 2010

Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders

Els Beirnaert; Cedric Jozef Neotere Ververken; Joost Alexander Kolkman; Roy Maarten Van


Archive | 2014

Interleukin-6 receptor binding polypeptides

Joost Alexander Kolkman; Els Beirnaert


Archive | 2010

Anti-IL-6R polypeptides and pharmaceutical compositions thereof

Els Beirnaert; Cedric Jozef Neotere Ververken; Joost Alexander Kolkman; Maarten Van Roy


Archive | 2014

Anti IL-6R polypeptides and compositions thereof

Els Beirnaert; Cedric Jozef Neotere Ververken; Joost Alexander Kolkman; Maarten Van Roy


Archive | 2008

PROVIDING IMPROVED IMMUNOGLOBULIN SEQUENCES BY MUTATING CDR AND/OR FR POSITIONS

Joost Alexander Kolkman

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