Jorge Albores-Saavedra

Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates

Data on patients with gallbladder cancer listed in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute were reviewed. Between 1977 and 1986, 3038 patients were recorded in the Program. Histologic grade, histologic type, stage of disease, and vascular invasion were correlated with outcome. Compared with all other histologic types of cancer, papillary carcinomas had the most favorable prognosis. The 2‐year survival rate for patients with papillary carcinoma was 47%. A correlation with survival existed between grade, stage of disease, and vascular invasion. The study confirmed that cancers of the gallbladder occur more often in older age groups and are more common in women. Almost 40% of cases are found at an advanced stage. For patients whose enolase tumor was limited to the gallbladder at the time of surgery, the 2‐year survival rate was 45% and the 5‐year rate was 32%.

Low grade fibromyxoid sarcoma: Fine-needle aspiration cytology with histologic, cytogenetic, immunohistochemical, and ultrastructural correlation

Although the histologic features of the recently described low grade fibromyxoid sarcoma are well established, to the authors knowledge there are no reports in the literature describing the cytologic features of this tumor by fine‐needle aspiration. Recognition of this lesion is important because of its indolent but metastasizing nature.

Carcinoma of the extrahepatic bile ducts : histologic types, stage of disease, grade, and survival rates

Data on patients with extrahepatic bile duct carcinomas recorded in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute were reviewed, We analyzed the records of 1766 patients reported during a 10‐year period (1977–1986). These tumors occurred primarily in older age groups and were slightly more common in males. Histologic grade, histologic types, and stage of disease are useful prognostic indicators. The 5‐year survival rate for patients with Stage I disease was 11%. Although carcinomas of the extrahepatic bile ducts are better differentiated than carcinomas arising in the gallbladder, they have a less favorable prognosis.

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region

Undifferentiated carcinomas with osteoclast‐like giant cells are rare pancreatic and periampulary neoplasms that morphologically mimic giant cell tumor of bone. Despite numerous publications based primarily on single case reports, the terminology, histogenesis, and biologic behavior of these tumors remain controversial.

Low grade salivary duct carcinoma: A distinctive variant with a low grade histology and a predominant intraductal growth pattern

Salivary duct carcinoma (SDC) has been established as a morphologically distinct and highly aggressive (HG) malignancy of the major salivary glands. However, a low grade (LG) or intermediate grade salivary duct neoplasm has not been described.

The WHO histological classification of tumors of the gallbladder and extrahepatic bile ducts. A commentary on the second edition

The second edition of the WHO Histological Classification of Tumors of the Gallbladder and Extrahepatic Bile Ducts is more comprehensive and detailed than the previous one. Advances in our understanding of dysplasia, carcinoma in situ, various lines of differentiation among the carcinomas, and the recognition of a variety of tumor‐like lesions have resulted in more than three times as many entities in the current classification as in the previous one. The new edition should facilitate pathologic, epidemiologic, and therapeutic comparisons. Cancer 1992; 70:410–414.

Noninvasive and minimally invasive papillary carcinomas of the extrahepatic bile ducts

Adenocarcinomas of the extrahepatic bile ducts (EBD) are uncommon neoplasms that are morphologically heterogenous and associated with a poor prognosis. Papillary carcinomas of the EBD, however, appear to follow a much less aggressive clinical course.

K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix

Mutations in the K‐ras oncogene and the p53 tumor suppressor gene are present in approximately 50% of colonic adenocarcinomas. Goblet cell carcinoids (GCCs) are uncommon neoplasms of the appendix that appear to be intermediate between carcinoid tumors and adenocarcinomas, both histologically and biologically. The current study was undertaken to examine the role of p53 and K‐ras mutations in the pathogenesis of GCCs and typical carcinoids (TCs) of the appendix.

Telomerase activity and expression of its RNA component in cervical lesions

The authors investigated telomerase enzyme activity and expression of its RNA component (hTR) during the multistage pathogenesis of cervical carcinomas, and correlated activation with histopathologic findings and human papillomavirus (HPV) infection.

Atypical angiomyolipoma of the kidney

The purpose of this study was to fully characterize and emphasize the salient features of an unusual variant of angiomyolipoma that the authors believe has been underrecognized.