Jorge Méndez

Rotatory behavior induced in nigra-lesioned rats by n-propylnoraporphine, apomorphine, and levodopa

Abstract The induction of rotatory behavior by N-propylnoraporphine, apomorphine, and levodopa (the last given with a peripheral metabolic inhibitor) was studied in rats with unilateral nigral lesions produced with 6-OH dopamine. Within the dose ranges studied, N-propylnoraporphine had longer lasting effects than did the other two drugs, and its activity was significantly increased by atropine.

Rotatory behavior induced by glycine injected into the substantia nigra of the rat.

Implantation of crystalline glycine and dopamine into the substantia nigra of the rat caused the rat to turn away from the injected side. This response is similar to that observed after electrical stimulation of the substantia nigra, or after amphetamine administration when the contralateral substantia nigra has been previously damaged with 6-hydroxydopamine. Rotatory behavior was not observed after injection of glycine into the caudate nucleus, whereas dopamine did induce this effect, as previously demonstrated.

Limbus lumbar and sacral vertebral fractures

Abstract e evaluated the fractures of the lumbar and sacral vertebral limbus by disc impingement at the peripheral ring apophysis in 23 adults associated with trauma in 16 of them. Lumbalgia, radicular pain and narrow canal symptoms are the presenting forms of this underdiagnosed pathology. CT is the best method of examination, while plain roentgenograms and MR are usually negative. Accurate diagnosis and surgical technique with larger exposure are needed to resect the fractured fragments and protruded disc material for decompressing the roots and the dural sac. Our results were very good on the majority of cases. [Neurol Res 2002; 24: 139-144]

Hypothermic Circulatory Arrest in Cerebral Aneurysm Surgery

Hypothermia for aneurysm surgery was first used more than 40 years ago and was shortly followed by deep hypothermic circulatory arrest (DHCA). Some giant, complex intracranial aneurysms have limited therapeutic alternatives, because the results of endovascular obliteration and indirect surgical approaches can be disappointing. In these cases, DHCA allows aneurysm surgery traditionally considered to be neither feasible nor advisable. Two cases of giant intracranial aneurysms successfully operated on with DHCA and a review of the literature on the subject are presented.