José Alexandre Coelho Pimentel
University of São Paulo
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Featured researches published by José Alexandre Coelho Pimentel.
Journal of Critical Care | 2014
Nara Aline Costa; Ana Lúcia Gut; Mariana de Souza Dorna; José Alexandre Coelho Pimentel; Silvia Maria Franciscato Cozzolino; Paula S. Azevedo; Ana Angélica Henrique Fernandes; Leonardo Antonio Mamede Zornoff; Sergio Alberto Rupp de Paiva; Marcos F. Minicucci
PURPOSE The purpose of the study is to determine the influence of serum thiamine, glutathione peroxidase (GPx) activity, and serum protein carbonyl concentrations in hospital mortality in patients with septic shock. MATERIALS AND METHODS This prospective study included all patients with septic shock on admission or during intensive care unit (ICU) stay, older than 18 years, admitted to 1 of the 3 ICUs of the Botucatu Medical School, from January to August 2012. Demographic information, clinical evaluation, and blood sample were taken within the first 72 hours of the patients admission or within 72 hours after septic shock diagnosis for serum thiamine, GPx activity, and protein carbonyl determination. RESULTS One hundred eight consecutive patients were evaluated. The mean age was 57.5 ± 16.0 years, 63% were male, 54.6% died in the ICU, and 71.3% had thiamine deficiency. Thiamine was not associated with oxidative stress. Neither vitamin B1 levels nor the GPx activity was associated with outcomes in these patients. However, protein carbonyl concentration was associated with increased mortality. CONCLUSIONS In patients with septic shock, oxidative stress was associated with mortality. On the other hand, thiamine was not associated with oxidative stress or mortality in these patients.
Journal of Trace Elements in Medicine and Biology | 2017
Gilmara P. Rodrigues; Silvia Maria Franciscato Cozzolino; Dilina do Nascimento Marreiro; Daniele R. C. Caldas; Kelcylene G. Silva; Kaluce Gonçalves de Sousa Almondes; José Machado Moita Neto; José Alexandre Coelho Pimentel; Cecília Maria Resende Gonçalves de Carvalho; Nadir do Nascimento Nogueira
The study evaluated the dietary intake of zinc and copper, as measured by plasma and erythrocyte concentrations, the Cu/Zn ratio and measure the erythrocyte superoxide dismutase enzyme (eSOD) activity and the relationship between these markers and the degree of dementia in elderly individuals with and without Alzheimers Disease (AD). A total of 93 elderly people aged 60-94 years were divided into two groups: with AD (n=44) and without AD (n=49). The NINCDS-ADRDA criteria were used for diagnosing AD, and dementia staging was determined using the Clinical Dementia Rating (CDR) scale. The dietary intake of Zn and Cu was obtained from a standard 3-day food record. Plasma and erythrocyte concentrations of the minerals were determined by flame atomic absorption spectrophotometry and by measuring eSOD activity in an automatic biochemical analyzer. The results showed dietary intake of Zn and Cu above the reference values with no differences observed between the two groups (p>0.05). Plasma and erythrocyte normocupremia as well as alteration in the Zn pool, with its reduced plasma concentrations and high in the erythrocytes, were observed in both groups (p>0.05). The plasma Cu/Zn ratio were not significantly different in patients with and without AD (p>0.05). The eSOD activity was high in both patient groups (p>0.05). However, among elderly patients with AD there was a positive correlation between this marker and dementia severity. According to our study results, we conclude that plasma and erythrocyte concentrations of Cu and Zn, as well as Cu/Zn ratio among elderly individuals is not related to Alzheimers Disease. However, antioxidant activity of eSOD is associated with dementia severity.
Critical Care | 2014
Nara Aline Costa; Ana Lúcia Gut; José Alexandre Coelho Pimentel; Silvia Maria Franciscato Cozzolino; Paula S. Azevedo; Ana Angélica Henrique Fernandes; Bertha F. Polegato; Suzana Erico Tanni; Rafael Dezen Gaiolla; Leonardo Antonio Mamede Zornoff; Sergio Alberto Rupp de Paiva; Marcos F. Minicucci
Nutrire | 2011
Liliane V. Pires; Ana Mara de Oliveira e Silva; Luciane L. Alencar; José Alexandre Coelho Pimentel; Jorge Mancini-Filho; Silvia Maria Franciscato Cozzolino
Nutrition | 2018
Renata Germano Borges de Oliveira Nascimento Freitas; Gabriel Hessel; Silvia Maria Franciscato Cozzolino; Ana Carolina Junqueira Vasques; Kaluce Gonçalves de Sousa Almondes; José Alexandre Coelho Pimentel; Roberto José Negrão Nogueira
Biological Trace Element Research | 2017
Liliane V. Pires; Adriana Aparecida Siviero-Miachon; Angela Maria Spinola-Castro; José Alexandre Coelho Pimentel; Luciana Sigueta Nishimura; Carla Soraya Costa Maia; Silvia Maria Franciscato Cozzolino
Journal of Critical Care | 2016
Nara Aline Costa; Ana Lúcia Gut; Mariana de Souza Dorna; José Alexandre Coelho Pimentel; Silvia Maria Franciscato Cozzolino; Paula S. Azevedo; Ana Angélica Henrique Fernandes; Leonardo Antonio Mamede Zornoff; Sergio Alberto Rupp de Paiva; Marcos F. Minicucci
Nutrire | 2012
Leila Hashimoto; Liliane V. Pires; Luciane L. Alencar; Tiago Franco de Oliveira; Ana Paula de Melo Loureiro; Verônica da Silva Bandeira; José Alexandre Coelho Pimentel; Silvia Maria Franciscato Cozzolino
Nutrire | 2012
Luciane L. Alencar; Liliane V. Pires; Leila Hashimoto; Verônica da Silva Bandeira; José Alexandre Coelho Pimentel; Angela M. S. e Castro; Silvia Maria Franciscato Cozzolino
Nutrire | 2011
Gilmara P. Rodrigues; Daniele R. C. Caldas; Kelcylene G. Silva; Kaluce Gonçalves de Sousa Almondes; José Alexandre Coelho Pimentel; José Machado Moita Neto; Cecília Maria Resende Gonçalves de Carvalho; Dilina do Nascimento Marreiro; Nadir do Nascimento Nogueira