José Antonio Avilés-Izquierdo

Frequency and characteristics of familial melanoma in Spain: The FAM-GEM-1 Study

Introduction Familial history of melanoma is a well-known risk factor for the disease, and 7% melanoma patients were reported to have a family history of melanoma. Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published, but these only include patients from specific areas of Spain and do not represent the data for the whole of Spain. Patients and methods An observational study conducted by the Spanish Group of Melanoma (GEM) analyzed the family history of patients diagnosed with melanoma between 2011 and 2013 in the dermatology and oncology departments. Results In all, 1047 patients were analyzed, and 69 (6.6%) fulfilled criteria for classical familial melanoma (two or more first-degree relatives diagnosed with melanoma). Taking into account other risk factors for familial melanoma, such as multiple melanoma, pancreatic cancer in the family or second-degree relatives with melanoma, the number of patients fulfilling the criteria increased to 165 (15.8%). Using a univariate analysis, we determined that a Breslow index of less than 1 mm, negative mitosis, multiple melanoma, and a history of sunburns in childhood were more frequent in familial melanoma patients, but a multivariate analysis revealed no differences in any pathological or clinical factor between the two groups. Conclusions Similar to that observed in other countries, familial melanoma accounts for 6.6% of melanoma diagnoses in Spain. Although no differences in the multivariate analysis were found, some better prognosis factors, such as Breslow index, seem more frequent in familial melanoma, which reflect a better early detection marker and/or a different biological behavior.

Dermoscopic Features of Circumscribed Palmar Hypokeratosis

Report of Cases | Case 1. A healthy woman in her 40s presented with a 10-year history of an asymptomatic, erythematous, and scaly plaque on the palmar aspect of the fifth finger on the right hand. Physical examination revealed a 7 × 3-mm atrophic and eroded plaque (Figure 1A, top). Polarized light dermoscopic examination showed a rounded pink lesion with a rim of peripheral stairlike desquamation. In the center of the lesion, a dotted pattern composed of white dots with regular distribution over a light pink background was observed (Figure 1A, bottom). On histopathological analysis, the periphery of the lesion showed an abrupt stairlike thinning of the horny layer forming an area of hypokeratosis in the center. Dilated congestive capillaries and a mild chronic inflammatory infiltrate were present in the papillary dermis (Figure 2).

Dermoscopic features in three cases of rounded and velvety epidermal naevus

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Dermoscopic features in 2 cases of angiolymphoid hyperplasia with eosinophilia

the Departments of Dermatology and Histopathology, ospital General Universitario Gregorio Mara~ n on. ing sources: None. licts of interest: None declared. int requests: Enrique Rodr ıguez-Lomba, MD, Department Dermatology, Hospital General Universitario Gregorio Mara~ n on, C/ Doctor Esquerdo, 46 28007 Madrid, Spain. E-mail: enriquerlomba@outlook.com. J Am Acad Dermatol 2016;75:e19-21. 0190-9622/

Who detects melanoma? Impact of detection patterns on characteristics and prognosis of patients with melanoma

36.00 a 2016 by the American Academy of Dermatology, Inc. http://dx.doi.org/10.1016/j.jaad.2016.02.1145