José Artur Sampaio

É possível diminuir o sangramento em hepatectomias sem a realização de exclusão vascular total ou parcial?: Resultados do uso de radiofrequência bipolar com agulhas resfriadas

BACKGROUND: Although the resection is the chosen procedure in the therapeutic treatment of liver malign lesions, the bleeding represents a factor of morbidity with a great impact in the hepatic surgery. With the means of minimizing this complication, several technological options have been utilized, being radiofrequency more recently among them, allowing the procedure to be realized with smaller incisions, without the need of vascular clamping, with minimum hepatic dissection, or bleeding. AIM: To present the results of the use of a new technique of hepatic parenchyma resection through parallel needles of bipolar radiofrequency developed by the authors themselves, verifying the impact in the trans-operation bleeding of patients subjected to hepatectomies. METHODS: Sixty patients were submitted to hepatic resection through the use of bipolar radiofrequency. The pre-operation bleeding was evaluated through the medication of the collected volume in the vacuum and by the weight difference in the compresses utilized during the procedure. All cases were monitored in their hepatocitary function through laboratory tests during the first week of the post-operation. RESULTS: The hepatic resections were realized with the mean of 87 minutes, mean incision size of 14 cm and mean bleeding of 58 ml. None of the patients received blood transfusion or derivatives. Central venous catheters were not utilized. All patients obtained fast anesthetic recuperation, leaving the recuperation room to the ward in less than 12 hours. The post-operation drainage was noted down until the drain removal occurring in all patients. The mean hospitalization time was of 3,2 days. After the elevation peak of the hepatic function tests in the first three days, all patients presented regression of them in a one month. CONCLUSION: It is possible, feasible and valid to use radiofrequency needle to perform hepatectomy, even larger ones, reducing bleeding.

A rare case of multiple skin metastases from squamous cell carcinoma of the esophagus

Summary Background: Esophageal cancer is an aggressive disease that generally has a poor prognosis. Patients affected by the disease usually present with signs and symptoms related to local growth of the tumor, gastrointestinal bleeding and nutritional impairment. Skin metastases are rare events, associated with advanced stage and poor survival. Case Report: We report the case of a 51-year-old man who presented poor general status, dysphagia, weight loss and skin lesions disseminated throughout the body. Endoscopic examination revealed the presence of esophageal squamous cell carcinoma, and biopsies of skin lesions showed metastasis of this cancer to the esophagus. Conclusions: We believe that any suspicious lesion that presents together with a history of gastrointestinal malignancy should be biopsied, since it can change the staging and prognosis of patients.

Estenoses biliares benignas: reparação e resultados com o uso de silastic transhepático transanastomótico

BACKGROUND: The medical advances is not always related to homogeneous good results for all the patients. This is the case of laparoscopic cholecystectomy, whose advantages are largely recognized in the medical literature. However, this operation most dreaded complication, iatrogenic major bile duct injury, is rising in the last years, despite the learning curve, and stabilized in a level higher than that experienced in open cholecystectomy. Among the features which can bring to this event a good outcome is the use of transhepatic transanastomotic tubes in association with the corrective hepaticojejunostomy. AIM: To report a 20 years experience on biliary reconstruction of bile duct injuries with the use of transhepatic transanastomotic tubes. METHODS: Data were analysed from 338 patients who underwent operation for major bile duct injuries between January 1988 and December 2009. RESULTS: All the 338 patients were submitted to Roux-en-Y hepaticojejunostomy (Hepp-Couinaud approach) or distinct cholangiojejunostomies, all with the use of transhepatic transanastomotic silastic tubes. A successful long-term result was achieved in 240 (92,9%) of 338 patients, including those who required subsequent procedures. CONCLUSION: Benign bile duct strictures near the hepatic duct confluence remains a surgical challenge. The use of silastic transhepatic transanastomotic tubes in high biliary tract reconstruction is an option which can provides a successful repair of bile duct injuries with low complication rates.

Utilização das hepatectomias centrais nas cirurgias hepatobiliares

The treatment of hepatobiliary diseases by central hepatectomies has been one of the most important challenges in surgical technique at the end of this century. Although different techniques were used in the last decades, only recently they have been carried out safely, drastically reducing the morbidity and mortality rates, and thus providing favorable results in treating different hepatic diseases. Whether the liver does or not present chronic liver disease, the integration of related multiple-disciplinary teams in this type of surgery and disease has allowed complex ablations, sometimes bordering on the limit of the possibility of life.Based on the principle of maintaining a viable remaining hepatocyte mass and function, the morphological and functional study of the liver during the preoperative period requires the frequent use of techniques to transplant liver segments, both for vascular reconstruction and for the reduction and conservation of the liver mass. Thus, the resection of any part of the liver with a minimum use of blood products has proved feasible with thorough knowledge of the anatomy of the liver, and the use of echography during surgery. Different central hepatectomy techniques are, thus, presented, discussing indications and surgical details of each of them.

Primitive Neuroectodermal Tumor of the Pancreas: A Case Report and Review of the Literature.

Primitive neuroectodermal tumors (PNETs) are presented as rare malignant neoplasms. In unusual cases, those neoplasms may arise in solid organs containing neuroendocrine cells, such as the pancreas. Herein the case of a 28-year-old patient that underwent gastroduodenopancreatectomy after the diagnosis of a huge mass (PNET) located in both head and body of the pancreas is reported. This is the 19th case of pancreatic PNET reported in literature.

Síndrome de Mirizzi em associação com níveis séricos de CA 19-9 superiores a 20.000U/ml: é possível?

Mulher de 83 anos foi atendida com historia de ictericia progressiva, coluria, hipocolia, prurido, dor em abdome superior e emagrecimento. Ao exame fisico apresentava-se icterica com discreta dor a palpacao do hipocondrio direito, sem evidencia de massas palpaveis. Os exames laboratoriais da admissao foram: bilirrubina total=26, bilirrubina direta=15,8, gama glutamil-transferase=829, fosfatase alcalina=518, transaminase glutâmico-oxalacetica=115, transaminase glutâmico-piruvica=92, hemoglobina=12,7, tempo de protrombina=89%, antigeno carboidrato 19-9=24.480. Destes, destaca-se o CA 19-9 de 24.480 U/mL. Tomografia computadorizada de abdome evidenciou dilatacao importante das vias biliares intra e extra-hepaticas e do segmento proximal do ducto hepatico comum (Figura 1). Observou-se tambem aparente compressao do hepatocoledoco pela vesicula biliar que se encontrava moderadamente distendida, com paredes espessadas, e provavel imagem de calculo na sua regiao infundibular medindo cerca de 2,0 cm. Ressalte-se que a possibilidade de neoplasia em via biliar nao podia ser afastada.A paciente em foi submetida a laparotomia exploradora, na qual foi evidenciado processo inflamatorio intenso no triângulo de Calot, com presenca de fistula entre a vesicula biliar - que apresentava-se escleroatrofica -, e o hepatocoledoco. Iniciou-se pela abertura da vesicula, onde foi identificado calculo unico de 2,3 cm no infundibulo, realizada biopsia da parede do coledoco e exploracao da via biliar a procura de outros calculos, que nao foram encontrados. Realizou-se coledocostomia com colocacao de dreno de Kehr e colangiografia de controle pelo dreno. Observou-se passagem do contraste para o duodeno e ausencia de lesoes ou calculos. A biopsia hepatica revelou reacao portal de padrao biliar com septos porta-porta, sugestivo de obstrucao de grandes ductos. Biopsias do coledoco/ducto hepatico/vesicula biliar nao revelaram malignidade, sendo compativeis com inflamacao aguda e cronica e edema, confirmando o diagnostico de sindrome de Mirizzi.A paciente evoluiu bem no pos-operatorio. Colangiografia no 9o dia foi normal. Houve normalizacao dos marcadores de colestase e decrescimo significativo do nivel serico do Ca 19-9 para 355,9 U/mL. No seguimento de tres anos, a paciente permanecia viva em bom estado geral sem evidencia de doenca maligna e com niveis sericos de CA 19-9 dentro da normalidade.

Características construtivas e funcionais das agulhas de radiofrequência bipolares resfriadas para reduzir o sangramento nas ressecções hepáticas

Background - To reduce bleeding in liver resection various technological options have been disclosed, among them the radiofrequency. The intent of the various methods is to avoid vascular clamping, less liver dissection and minimize bleeding. Aim - To present a new technique of parallel bipolar radiofrequency needles developed by the authors and the technical details. Methods - The needle system has two parallel electrodes (18 gauge each) of 25 cm in length, separated by a distance of 1.5 cm, and only distal 4 cm dissipate energy generated by a bipolar electrocautery. These needles are cooled by an internal cooling system for continuous flow of cold sterile distilled water at 0oC, whose temperature is maintained through the presence of sterile distilled water ice. The operation is performed under general anesthesia and is not used central venous catheters during or after the procedure. The incisions may be right subcostal and median supra-umbilical. Results - The inical use in liver resection showed an average 87 minutes operation time, average size of abdominal incision of 14 cm and 58 ml of blood loss during surgery. No patient in the inical group received transfusion of blood or blood products. Conclusion - The bipolar radiofrequency cooled needles are viable and reduce bleeding in liver resection. ABCDDV/785

A case of oncogenic osteomalacia owing to inguinal tumor

Abstract The oncogenic hypophosphatemic osteomalacia is a very incapacitating disease and the mortality rate, mainly due to metabolic disorder, depends on the early diagnosis, since the surgery is curative. The major difficulty is to consider this kind of disease in patients with complex clinical presentation. Moreover, medical centers have to provide a good diagnostic infrastructure because these tumors, in most cases, are small and do not have an obvious site. This case report is about a man with a rapid loss of strength and muscle mass, which had his diagnosis in a late, culminating in significant deformities and organic dysfunctions with clinical repercussions. However, the fast diagnosis with appropriate tests determined the stop point of the evolution of disease and marked the beginning of metabolic recovery. This case reinforces the global problem health care infrastructure and the access to diagnostic equipment, demonstrating the impact on the patient’s health of our service.

Oncogenic hypophosphatemic osteomalacia: From the first signal of disease to the first signal of healthy

Highlights • Oncogenic hypophosphatemic osteomalacia is an uncommon paraneoplastic syndrome. Neoplasia with high morbimortality if not detected early.• A free margin excision is necessary to stop deformity evolution.

Use of Left Gastric Vein as an Alternative for Portal Flow Reconstruction in Liver Transplantation

Portal vein thrombosis is observed in up to 10% of liver transplant candidates, hindering execution of the procedure. A dilated gastric vein is an alternative to portal vein reconstruction and decompression of splanchnic bed. We present two cases of patients with portal cavernoma and dilated left gastric vein draining splanchnic bed who underwent liver transplantation. The vein was dissected and sectioned near the cardia; the proximal segment was ligated with suture and the distal segment was anastomosed to the donor portal vein. Gastroportal anastomosis is an excellent option for portal reconstruction in the presence of thrombosis or hypoplasia. It allows an adequate splanchnic drainage and direction of hepatotrophic factors to the graft.