José Eduardo de Aguilar-Nascimento

Guidelines for Perioperative Care for Pancreaticoduodenectomy: Enhanced Recovery After Surgery (ERAS(®)) Society Recommendations.

BackgroundProtocols for enhanced recovery provide comprehensive and evidence-based guidelines for best perioperative care. Protocol implementation may reduce complication rates and enhance functional recovery and, as a result of this, also reduce length-of-stay in hospital. There is no comprehensive framework available for pancreaticoduodenectomy.MethodsAn international working group constructed within the Enhanced Recovery After Surgery (ERAS®) Society constructed a comprehensive and evidence-based framework for best perioperative care for pancreaticoduodenectomy patients. Data were retrieved from standard databases and personal archives. Evidence and recommendations were classified according to the GRADE system and reached through consensus in the group. The quality of evidence was rated “high”, “moderate”, “low” or “very low”. Recommendations were graded as “strong” or “weak”.ResultsComprehensive guidelines are presented. Available evidence is summarised and recommendations given for 27 care items. The quality of evidence varies substantially and further research is needed for many issues to improve the strength of evidence and grade of recommendations.ConclusionsThe present evidence-based guidelines provide the necessary platform upon which to base a unified protocol for perioperative care for pancreaticoduodenectomy. A unified protocol allows for comparison between centres and across national borders. It facilitates multi-institutional prospective cohort registries and adequately powered randomised trials.

Benefits of early enteral nutrition with glutamine and probiotics in brain injury patients

Brain injury patients have higher energy and protein expenditures and are prone to infections. The aim of the present study was to evaluate the results of early enteral feeding with glutamine and probiotics in brain injury patients. Twenty-three brain injury patients (Glasgow score between 5-12 and therapeutic intervention scoring system>20) were studied. Three patients were excluded to leave 20 remaining patients. Patients were randomized to receive either an early enteral diet (control group, n=10) or the same formula with glutamine and probiotics added (study group, n=10) for a minimum of 5 days (range, 5-14 days). The diets were isocaloric and isonitrogenous [35 kcal.kg(-1).day(-1) (where 1 kcal approximately 4.184 kJ) and 1.5 g of protein.kg(-1).day(-1)]. Main outcome measures were the incidence of infection, the length of stay in the intensive care unit and the number of days requiring mechanical ventilation. The two groups were homogeneous in gender, age, nutritional status and severity of trauma. There was no mortality during the study period. The infection rate was higher in controls (100%) when compared with the study group (50%; P=0.03) and the median (range) number of infections per patient was significantly greater (P<0.01) in the control group [3 (1-5)] compared with the study group [1 (0-3)]. Both the critical care unit stay [22 (7-57) compared with 10 (5-20) days; P<0.01; median (range)] and days of mechanical ventilation [14 (3-53) compared with 7 (1-15) days; P=0.04; median (range)] were higher in the patients in the control group than in the study group. We conclude that the enteral formula containing glutamine and probiotics decreased the infection rate and shortened the stay in the intensive care unit of brain injury patients.

Clinical Costs of Feeding Tube Placement

BACKGROUND Although small-bore tube placement is common, insertion can lead to serious complications. We investigated the use of radiographs, fluoroscopy, feeding tubes, and complications associated with blind feeding-tube placement. METHODS The electronic and paper records of adult patients receiving a small-bore feeding tube in 2005 were retrospectively reviewed for the following variables: demographics, desired location (gastric or postpyloric), number of radiographs, number of tubes per individual, time interval between medical prescription, tube placement and delivery of the diet, complications, transport for fluoroscopy, and hospital location of placement (intensive care unit vs floor). RESULTS We identified 1822 tubes placed into 729 patients (male: 449, 61.6%; female: 280, 38.4%; median age: 59 years old, range 18-98). All tubes were placed by nurses unless fluoroscopically placed in radiology or placed after head and neck surgery in the operating room. An average of 2.5 (range 1-20) tubes was used per patient. A total of 2696 radiographs were obtained for an average of 3.7 (range 0-32) films per patient and 1.5 (range 0-11) per feeding tube. Successful placement was higher for intragastric (93.3%) than for postpyloric position (60.4%; p < .001). Fluoroscopy was needed in 18.6% of the patients, mostly for postpyloric insertion (p < .001). Respiratory tree misplacement occurred in 23 (3.2%) patients; 9 (1.2%) had a pneumothorax and 4 (0.5%) died. Patients with a malpositioned feeding tube underwent more tube insertions (6.8 +/- 5.4; range 2-20) than patients without complications (2.2 +/- 1.8; range 1-18; p < .001). CONCLUSIONS The incidence of airway misplacement of feeding tubes (3.2%) at a major tertiary referral university hospital was alarming. Mandatory radiographs may eliminate the risk of respiratory administration of feedings but not misplacements. The associated costs of radiographs, unsuccessful placements, fluoroscopy, and complications are significant. A solution to this problem will require focused attention and development of specific protocols, possibly using new technologies.

Reducing preoperative fasting time: A trend based on evidence

Preoperative fasting is mandatory before anesthesia to reduce the risk of aspiration. However, the prescribed 6-8 h of fasting is usually prolonged to 12-16 h for various reasons. Prolonged fasting triggers a metabolic response that precipitates gluconeogenesis and increases the organic response to trauma. Various randomized trials and meta-analyses have consistently shown that is safe to reduce the preoperative fasting time with a carbohydrate-rich drink up to 2 h before surgery. Benefits related to this shorter preoperative fasting include the reduction of postoperative gastrointestinal discomfort and insulin resistance. New formulas containing amino acids such as glutamine and other peptides are being studied and are promising candidates to be used to reduce preoperative fasting time.

Effects of preoperative feeding with a whey protein plus carbohydrate drink on the acute phase response and insulin resistance. A randomized trial

BackgroundProlonged preoperative fasting increases insulin resistance and current evidence recommends carbohydrate (CHO) drinks 2 hours before surgery. Our hypothesis is that the addition of whey protein to a CHO-based drink not only reduces the inflammatory response but also diminish insulin resistance.MethodsSeventeen patients scheduled to cholecystectomy or inguinal herniorraphy were randomized and given 474 ml and 237 ml of water (CO group) or a drink containing CHO and milk whey protein (CHO-P group) respectively, 6 and 3 hours before operation. Blood samples were collected before surgery and 24 hours afterwards for biochemical assays. The endpoints of the study were the insulin resistance (IR), the prognostic inflammatory and nutritional index (PINI) and the C-reactive protein (CRP)/albumin ratio. A 5% level for significance was established.ResultsThere were no anesthetic or postoperative complications. The post-operative IR was lower in the CHO-P group when compared with the CO group (2.75 ± 0.72 vs 5.74 ± 1.16; p = 0.03). There was no difference between the two groups in relation to the PINI. The CHO-P group showed a decrease in the both CRP elevation and CRP/albumin ratio (p < 0.05). The proportion of patients who showed CRP/albumin ratio considered normal was significantly greater (p < 0.05) in the CHO-P group (87.5%) than in the CO group (33.3%).ConclusionsShortening the pre-operative fasting using CHO and whey protein is safe and reduces insulin resistance and postoperative acute phase response in elective moderate operations.Trial registrationClinicalTrail.gov NCT01354249

Acerto pós-operatório: avaliação dos resultados da implantação de um protocolo multidisciplinar de cuidados peri-operatórios em cirurgia geral

OBJETIVO: O objetivo do presente estudo foi avaliar os resultados clinicos iniciais apos a implementacao do projeto Acerto Pos-operatorio (ACERTO) em pacientes operados num servico universitario de cirurgia geral. METODO: 161 pacientes foram prospectivamente observados durante dois periodos: o primeiro, entre janeiro a junho de 2005 (n=77) formado por pacientes submetidos a condutas convencionais (periodo PRE-ACERTO) e o segundo, entre agosto a dezembro de 2005 (n=84), formado por pacientes submetidos a um novo protocolo de condutas peri-operatorio estabelecidas pelo projeto ACERTO (periodo POS-ACERTO). A coleta de dados nos dois periodos ocorreu sem o conhecimento dos profissionais do servico. As variaveis observadas foram: indicacao de suporte nutricional pre-operatorio, tempo de jejum pre e pos operatorio, volume de hidratacao, uso de sondas e drenos, tempo de internacao e morbidade pos-operatoria. RESULTADOS: Na fase pos-ACERTO, o percentual de pacientes desnutridos que receberam suporte nutricional foi treses vezes maior (78,6%; 11/14 vs. 23,5%; 4/17; p <0.01). Houve uma diminuicao no tempo de jejum pre (16 [8-27] vs 5 [2-20] horas, p<0,01) e pos-operatorio (3 [1-15] vs 1 [1-6] dias, p<0,01) e na hidratacao venosa (8 [1-63,5] vs 4 [0,5-63] litros, p<0,001) na segunda fase do estudo. O conjunto de mudancas determinou uma reducao de dois dias no tempo de internacao (5 [2-46] vs 3 [1-64] dias, p<0,05) e de 60% na morbidade pos-operatoria (18,2%;14/77 vs 7,1%;6/84, p=0,03; RR=2,55, IC95%1,03-6,29, p<0,05). CONCLUSOES: A adocao das medidas multidisciplinares peri-operatorias como as do projeto ACERTO e factivel dentro da nossa realidade e pode, melhorar a morbidade e diminuir o tempo de internacao em cirurgia geral.

Early enteral nutrition with whey protein or casein in elderly patients with acute ischemic stroke: A double-blind randomized trial

OBJECTIVE The aim of this study was to investigate the effects of an early enteral formula containing whey protein, in comparison to a standard enteral formula containing casein as the protein source, on the levels of glutathione and inflammatory markers in aged patients with acute ischemic stroke. METHODS Thirty-one elderly patients (12 males and 19 females; median age = 74 [range,65-90] y old) with ischemic stroke were randomized to receive early nasogastric feeding (35 kcal/kg/d and 1.2 g of protein/kg/d) with either a formula containing polymeric [corrected] casein (casein group, n =16) or another isocaloric and isonitrogenous formula containing hydrolyzed whey protein (WP group, n = 15) for 5 d. The primary endpoints of the study were the changes in the serum levels of glutathione peroxidase, C-reactive protein (CRP), and interleukin 6 (IL-6). RESULTS Twenty-five patients completed the study (10 in the WP group and 15 in the casein group). Mortality was similar between groups (33%; P = 1.00) and was associated with higher serum IL-6 (73.7 ± 24.7 versus 16.6 ± 2.4 pg/dL; P = 0.04) and CRP (82.0 ± 35.6 versus 48.3 ± 14.5 mg/L; P = 0.02) levels. Albumin levels dropped from the first to the fifth feeding day only in the casein group (P < 0.01). Serum IL-6 decreased (62.7 ± 47.2 to 20.6 ± 10.3 pg/dL; P = 0.02) and glutathione increased (32.2 ± 2.1 to 39.9 ± 6.8 U/G Hb; P = 0.03) only in the WP group. Serum IL-6 was lower (P = 0.03) and glutathione was higher (P = 0.03) in whey protein-fed patients than in the casein group. CONCLUSION Enteral formula containing whey protein may decrease inflammation and increase antioxidant defenses in elderly patients with ischemic stroke, compared to casein-containing formula.

Espessura do músculo adutor do polegar: um método rápido e confiável na avaliação nutricional de pacientes cirúrgicos

OBJECTIVE: Investigate whether the right adductor pollicis muscle thickness is a reliable method to evaluate the nutritional status of surgical patients and whether it correlates or not correlate to other anthropometric, biochemical, and clinical parameters. METHODS: Cross-sectional study evaluating 87 patients candidates to major operations of the gastrointestinal tract. All were submitted to global subjective evaluation, traditional anthropometry (arm circumpherence ; triceps skin fold; and arm muscle circumpherence, serum albumin, lymphocytes and measurement of in both hands. RESULTS: The mean right adductor pollicis muscle thickness in dominant hand was 12,64 ± 3,19 mm and in non-dominant hand (EMAPND) 12,23 ± 2,9 mm. Sensitivity was 72,37% for left adductor pollicis muscle and 77,33% for left adductor pollicis muscle thickness being the cut-offs given by the ROC curve (13,4 and 13,1mm respectively). Specificity was 100% for both hands. There was a significantly correlation (P<0.01) for right adductor pollicis muscle thickness with all anthropometric parameters. The mean value for normal individuals was significantly greater (P<0.001) than for mild malnourished which was greater (p<0.05) when compared to patients with severe malnutrition. CONCLUSION: right adductor pollicis muscle thickness is a low-cost, reliable, and trustworthy method to assess nutritional status that can be easily and safety used in clinical practice for surgical patients.

Alimentação precoce após anastomoses intestinais: riscos ou benefícios?

BACKGROUND: Oral intake after intestinal anastomoses has traditionally been prescribed only after the resolution of ileus. The aim of this study was to evaluate the immediate results of early oral feeding in postoperative course of intestinal anastomoses. METHODS: 43 consecutive patients submitted to operations associated with intestinal anastomoses were randomized to two groups: early group (N=23) allowed to oral intake after 24 h of operation and conventional group (N=20) in which feeding was allowed only after the ileus resolution. Groups were statistically similar for age, gender, nutritional status, duration of operation, local and type of anastomoses, type of anesthesia and use of morphine. RESULTS: Three (13%) patients of early group and two (10%) of conventional presented vomiting requiring nasogastric decompression (P.0.05). Three (7.3%) patients, two (10%) in early feeding group and one (5%) in conventional group died (P>0.05). There was no difference between the groups for morbidity. Two anastomotic dehiscences occurred in each group. Passage of flatus was reported earlier (P=0.01) in early feeding group (35±13 h) when compared with conventional group (44±12 h). Hospital stay was similar between the two groups (conventional group = 12 [6-36] days versus early feeding group = 10 [5-29] days). CONCLUSIONS: The return of oral feeding on the first postoperative day in patients submitted to intestinal anastomoses is safe, not associated with the occurrence of anastomotic dehiscence and moreover, related to a shorter resolution of ileus.

Evaluation of the effects of a preoperative 2-hour fast with maltodextrine and glutamine on insulin resistance, acute-phase response, nitrogen balance, and serum glutathione after laparoscopic cholecystectomy: a controlled randomized trial.

BACKGROUND Prolonged preoperative fasting increases insulin resistance (IR). The authors investigated whether an abbreviated preoperative fast with glutamine (GLN) plus a carbohydrate (CHO)-based beverage would improve the organic response after surgery. METHODS Forty-eight female patients (19-62 years) were randomized to either standard fasting (control group) or to fasting with 1 of 3 different beverages before video-cholecystectomy. Beverages were consumed 8 hours (400 mL; placebo group: water; GLN group: water with 50 g maltodextrine plus 40 g GLN; and CHO group: water with 50 g maltodextrine) and 2 hours (200 mL; placebo: water; GLN: water with 25 g maltodextrine plus 10 g GLN; and CHO: water with 25 g maltodextrine) before anesthesia. Blood samples were collected pre- and postoperatively. RESULTS The mean (SEM) postoperative homeostasis model assessment-insulin resistance was greater (P < .05) in control patients (4.3 [1.3]) than in the other groups (placebo, 1.6 [0.3]; CHO, 2.3 [0.4]; and GLN, 1.5 [0.1]). Glutathione was significantly higher (P < .01) in the GLN group than in both CHO and control groups. Interleukin-6 increased in all groups except the GLN group. The C-reactive protein/albumin ratio was higher (P < .05) in controls than in CHO and GLN groups. The nitrogen balance was less negative in GLN (-2.5 [0.8] gN) than in both placebo (-9.0 [2] gN; P = .001) and control (-6.6 [0.4] gN; P = .04) groups. CONCLUSIONS Preoperative intake of a GLN-enriched CHO beverage appears to improve IR and antioxidant defenses and decreases the inflammatory response after video-cholecystectomy.