José M. Cancela

Physical Exercise in MCI Elderly Promotes Reduction of Pro-Inflammatory Cytokines and Improvements on Cognition and BDNF Peripheral Levels

The benefits of physical exercise to reduce low-grade inflammation and improve Brain-Derived Neurotrophic Factor (BDNF) levels and cognitive function became a growing field of interest. Low-grade inflammation is common during aging and seems to be linked to neurodegenerative process. Regular physical exercises can help to reduce pro-inflammatory cytokines levels and to improve BDNF peripheral concentrations. The main goal of this research was to analyze the effects of a 16-week multimodal physical exercise program on peripheral BDNF levels and on Tumor Necrosis-α (TNF-α) and Interleukin- 6 (IL-6) as pro-inflammatory markers in cognitive healthy elderly individuals and in elderly with mild cognitive impairment (MCI). Cognitive functions were assessed by the Montreal Cognitive Assessment (MoCA) prior to and after the intervention. Thirty cognitively healthy participants and thirty-seven MCI participants were assigned to the control (CG) and trained (TG) groups. The TG participated in a multimodal physical training program for a 16-week period. The results showed a significant between-subjects interaction, which indicates the beneficial contribution of training on the reduction of TNF-α (p=0.001) and IL-6 (p<0.001) and on the improvement of BDNF (p<0.001) peripheral concentrations. Cognitive functions also presented significant improvements for MCI trained group (p=0.03). In conclusion, physical exercise was effective to reduce pro-inflammatory cytokines and to improve BDNF peripheral levels, with positive reflexes on cognition. To the best of our knowledge, this is the first study that evaluated longitudinally the effects of a multimodal physical exercises protocol on peripheral concentrations of pro-inflammatory cytokines and cognition performance in elderly MCI individuals.

Effects of two different intensities of aerobic exercise on elderly people with mild cognitive impairment: a randomized pilot study:

Objective: To evaluate the effect of different intensities of aerobic exercise on elderly people with mild cognitive impairment. Design: A randomized trial. Setting: Residential care homes for elderly people. Subjects: Forty-eight patients were included in the study. Interventions: The patients were randomized in three groups. Group A performed aerobic exercise at 40% of heart rate reserve, group B did the same at 60% and group C carried out recreational activities. The duration of the study was three months. Main measures: Cognitive level and functional ability were assessed by means of the Mini Mental State Examination and the Timed Up and Go test before the intervention, at the end of it and three months later as a follow-up. Results: After completion of the aerobic training programme, the patients’ Mini Mental State Examination scores improved marginally (group A from 19.8 ± 5.1 to 20.6 ± 7.3; group B from 20.8 ± 4.6 to 21 ± 5.4). A similar trend was observed for the Timed Up and Go test scores (group A from 18.8 ± 5.3 to 18.5 ± 5 seconds; group B from 15.4 ± 4.2 to 14.3 ± 5.1 seconds). However, no statistically significant differences were found at any time during the evaluation regarding cognitive level and functional autonomy among the three groups. Conclusion: In this pilot study, intensity does not seem to be a determining factor when aerobic exercise is performed by people with mild cognitive impairment.

Lifestyle and health among Spanish university students: differences by gender and academic discipline

Today the need to analyze health behaviour from a gender perspective is as imminent as ever, particularly at university, where the number of women who register is on the rise and has exceeded the number of male students worldwide. We carried out a prevalence study aimed at analyzing Spanish university students’ lifestyles and identify differences according to gender and academic discipline. Of 3,646 eligible subjects doing university courses related to health (Group A), education (Group B) and other professions (Group C), 985 (27.0%) participated in the study. Information was elicited about their physical activity level, disturbed eating attitudes, consumption of alcohol, tobacco and illegal substances. Prevalence and Odds Ratios (OR) were calculated according to sex and kind of academic discipline. The obtained data confirmed that only 27.4% of the students were considered as sufficiently active, while 14.9% of them suffered from disturbed eating attitudes (DEA). Women were particularly less active (OR 0.46 (0.32–0.66); p < 0.0001), and more sedentary than men (OR 1.40 (1.00–1.97); p = 0.03). Binge drinking was more frequent in female than in male students (OR 1.79 (1.29–2.47); p = 0.0004). A third of the analyzed sample admitted that they had used illegal substances, while a lower consumption prevalence was found in women (OR 0.53 (0.40–0.71); p < 0.0001). The studied population was not very active (27.4%), especially women (OR = 0.45). Therefore, it seems that Spanish university students lead an unhealthy lifestyle, a situation which seems more conspicuous amongst females.

Effect of a multimodal exercise program on sleep disturbances and instrumental activities of daily living performance on Parkinson's and Alzheimer's disease patients

To assess the contribution of a multimodal exercise program on the sleep disturbances (SD) and on the performance of instrumental activities daily living (IADL) in patients with clinical diagnosis of Alzheimers disease (AD) and Parkinsons disease patients (PD).

Batteries assessing health related fitness in the elderly: a brief review

Evaluation of physical functioning is a key issue in clinical geriatrics and in aging research. In recent years, different physical performance batteries in which individuals are asked to perform several tasks and are evaluated using different criteria have been designed and used in elderly populations. These batteries include different types of test which range from basic motor abilities to relevant everyday activities, depending on the construct area in the domain of physical function that must be measured. This paper reviews and classifies the main physical functioning batteries that can be found in the scientific field of aging research in order to provide knowledge on selection, administration, and interpretation of this indispensable assessment tools.

Effects of Pilates method in physical fitness on older adults. A systematic review

Pilates method is employed for physical and mental conditioning. Elderly people could be benefited from a patterned and regulated conditioning work based on Pilates method. We performed a systematic review to assess the evidence on the effects of Pilates method in physical fitness on older adults. Our search included the following databases: MEDLINE-PubMed, Scopus and CINAHL Plus with Full Text via EBSCO and SPORTDiscus databases (up to April 2014). A summary of the results was performed using a best evidence synthesis and was reported according to the systematic review method proposed by Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement. The Physiotherapy Evidence Database (PEDro) scale was used to assess the methodology quality of selected studies. Seventeen experimental studies were included in this review. Fourteen were randomized controlled trials (RCT) and three clinical controlled trials (CCT). Quality scores according to PEDro indicate low quality of the included studies (range 1–6, mean 3.8 ± 1.2). The most studied components related to physical fitness were neuromotor fitness (n = 11), muscle strength (n = 8), cardiorespiratory endurance (n = 4), body composition (n = 4) and flexibility (n = 4). Results indicate that Pilates method seems to present positive effects in neuromotor fitness, especially in static and dynamic balance. Related to the other components of physical fitness (cardiorespiratory endurance, muscle strength, body composition and flexibility), contradictory results were observed. The Pilates method indicates to be an appropriate exercise modality in order to improve balance on older adults. Nevertheless, more intervention research is needed to build a solid knowledge base about the health benefits of Pilates method on older people, especially regarding the other components of physical fitness.

Effectiveness of water-based exercise in people living with Parkinson’s disease: a systematic review

This systematic review summarizes the relatively scant literature concerning the effectiveness of water-based exercise (WBE) interventions in people with Parkinson’s disease (PD). Databases MEDLINE, EMBASE, PEDro, Scopus, and SportDiscus were searched from the earliest available date to December 2011. Studies had to meet the following selection criteria: (1) the target population was patients with PD; (2) the effects of a WBE intervention (as the primary intervention) were tested; (3) the abstract of the research was available in English. Selected studies were subject to unmasked quality assessment by applying a methodological scoring with a possible maximum score of 15 points. Twelve studies met the inclusion criteria, although only three of them achieved a methodological quality score above 10 points. Collectively, the data showed that WBE has some beneficial short-term effects on the impact that PD has on the patients (mainly on their motor symptoms and on their functional mobility), as well as on their quality of life. This review provides evidence that WBE is safe for patients with PD, but there is a lack of hard evidence regarding its beneficial effects. Further randomized and controlled trials with larger sample sizes are required.

Correlation between the Yale Physical Activity Survey (YPAS) and a submaximal performance-based test: A study in a population of elderly Spanish women

The aim of this study is to research the degree of correlation between the Spanish version of the questionnaire YPAS and the 6-minute walking test (6MWT) in women over 60. In addition, the authors analyzed the relationship between the variables age and body mass index (BMI) and the walked distance. The study was carried out with 44 elderly women (68.1 ± 5.4 years) who filled in the questionnaire and immediately afterwards performed the 6MWT. Total time and energy expenditure (EE) values obtained in the questionnaire are significantly correlated with the 6MWT (p=0.02; p=0.01, respectively), while BMI and age showed an inverse association (r=-0.433; r=-0.318, respectively) with the walked distance. The Spanish version of YPAS is beginning to be considered as a valid and useful tool for habitual physical activity (PA) measurement and can be used among elderly Spanish speaking women.

Reliability of Two Field-Based Tests for Measuring Cardiorespiratory Fitness in Preschool Children.

Abstract Ayán, C, Cancela, JM, Romero, S, and Alonso, S. Reliability of two field-based tests for measuring cardiorespiratory fitness in preschool children. J Strength Cond Res 29(10): 2874–2880, 2015—This study is aimed at analyzing the reliability of 2 field-based cardiorespiratory fitness tests when applied to a sample specifically made up of preschool-aged children. A total of 97 preschoolers (mean age: 4.36 ± 0.4 years; 50.5% girls) performed Course-Navette and Mini-Cooper tests 3 times (familiarization test and retest). The scores obtained were compared with the results provided by the 3-minute shuttle run test, which is considered to be a reliable field-based test for preschoolers. The Mini-Cooper test showed a high reliability for children aged 4 (intraclass correlation coefficient [ICC]: 0.942; 95% confidence interval [CI]: 0.903–0.965) and 5 years old (ICC: 0.946; 95% CI: 0.893–0.973). The reliability of Course-Navette was also high for both 4-year-old (ICC: 0.909; 95% CI: 0.849–0.945) and 5-year-old children (ICC: 0.889; 95% CI: 0.780–0.944). The mean scores of the 3-minute shuttle run test did not show a significant correlation with the mean scores obtained in the Mini-Cooper test and in the Course-Navette test in the 4-year-old children. The results of this study suggest that Course-Navette and Mini-Cooper tests are reliable measures of cardiorespiratory fitness that can be used to assess health-related fitness in preschool children. Nevertheless, some considerations must be taken into account before administering them.

An evaluation of questionnaires assessing physical activity levels in youth populations

The aim of this study was to revise and organize according to recall time based criteria, questionnaires created and validated to assess the level of physical activity in children and adolescents, with the intention of enabling their proper understanding and subsequent use by nurses and health care professionals. In order to determine the questionnaires’ quality, their degree of reliability and validity was the main feature to be taken into account. Thirty-eight papers were retrieved and analyzed, 31 of which were aimed at designing and validating a questionnaire intended for physical activity (PA) level assessment in youth populations (four to 19 year olds). The most widely used questionnaires were those whose recall time spans from one to seven days. In general, all questionnaires were characterized by the use of pen-and-paper format and scarce utilization of new technologies. Based upon validity and reliability criteria, in order to assess PA level in children and adolescents, nurses should use the “Children’s Leisure Activities Study Survey” and the “Flemish Physical Activity Computer Questionnaire”, respectively. There is a need for the validation of these tools in other languages and cultures.