José Manuel de la Cuétara

Functional craniology and brain evolution: from paleontology to biomedicine.

Anatomical systems are organized through a network of structural and functional relationships among their elements. This network of relationships is the result of evolution, it represents the actual target of selection, and it generates the set of rules orienting and constraining the morphogenetic processes. Understanding the relationship among cranial and cerebral components is necessary to investigate the factors that have influenced and characterized our neuroanatomy, and possible drawbacks associated with the evolution of large brains. The study of the spatial relationships between skull and brain in the human genus has direct relevance in cranial surgery. Geometrical modeling can provide functional perspectives in evolution and brain physiology, like in simulations to investigate metabolic heat production and dissipation in the endocranial form. Analysis of the evolutionary constraints between facial and neural blocks can provide new information on visual impairment. The study of brain form variation in fossil humans can supply a different perspective for interpreting the processes behind neurodegeneration and Alzheimer’s disease. Following these examples, it is apparent that paleontology and biomedicine can exchange relevant information and contribute at the same time to the development of robust evolutionary hypotheses on brain evolution, while offering more comprehensive biological perspectives with regard to the interpretation of pathological processes.

A Bivariate Approach to the Variation of the Parietal Curvature in the Genus Homo

The parietal bones approximately cover the extension of the underlying parietal lobes. Although the boundaries of these two anatomical elements do not coincide, during morphogenesis the growth of the parietal bones is largely induced by the pressure exerted by the parietal lobes. Modern humans display larger parietal chords and arcs compared with non‐modern human species. However, the variation of these variables have not been analyzed before according to the covariation with the general endocranial diameters. When the curvature of the parietal bones is regressed onto the main neurocranial distances, modern humans show larger relative values, suggesting not only an absolute enlargement but a definite allometric change. Taking into account the morphogenetic relationships with the parietal lobes, these results further support previous hypotheses suggesting a relative enlargement of these cortical areas in Homo sapiens, by using simple and reliable homologous neurocranial arcs. Anat Rec, 2011.

Midsagittal brain variation and MRI shape analysis of the precuneus in adult individuals

Recent analyses indicate that the precuneus is one of the main centres of integration in terms of functional and structural processes within the human brain. This neuroanatomical element is formed by different subregions, involved in visuo‐spatial integration, memory and self‐awareness. We analysed the midsagittal brain shape in a sample of adult humans (n = 90) to evidence the patterns of variability and geometrical organization of this area. Interestingly, the major brain covariance pattern within adult humans is strictly associated with the relative proportions of the precuneus. Its morphology displays a marked individual variation, both in terms of geometry (mostly in its longitudinal dimensions) and anatomy (patterns of convolution). No patent differences are evident between males and females, and the allometric effect of size is minimal. However, in terms of morphology, the precuneus does not represent an individual module, being influenced by different neighbouring structures. Taking into consideration the apparent involvement of the precuneus in higher‐order human brain functions and evolution, its wide variation further stresses the important role of these deep parietal areas in modern neuroanatomical organization.

The evolution of the meningeal vascular system in the human genus: From brain shape to thermoregulation

The imprints of the middle meningeal vessels make it possible to analyze vascularization in fossil specimens. The association between changes in the cortical anatomy and vascular organization raises questions about the actual physiological meaning of these features, most of all when dealing with the origin of the modern human brain. Metabolism and thermoregulation may be relevant factors in influencing morphological adaptations between brain and vessels. This study is aimed at investigating the relationships between endocranial morphology and endocranial vessels in modern humans and to analyze the pattern of heat dissipation through the endocranial surface in fossil specimens.

The brain and the braincase: a spatial analysis on the midsagittal profile in adult humans.

The spatial relationships between brain and braincase represent a major topic in surgery and evolutionary neuroanatomy. In paleoneurology, neurocranial landmarks are often used as references for brain areas. In this study, we analyze the variation and covariation of midsagittal brain and skull coordinates in a sample of adult modern humans in order to demonstrate spatial associations between hard and soft tissues. The correlation between parietal lobe size and parietal bone size is very low, and there is a marked individual variation. The distances between lobes and bones are partially influenced by the dimensions of the parietal lobes. The main pattern of morphological variability among individuals, associated with the size of the precuneus, apparently does not influence the position of the neurocranial sutures. Therefore, variations in precuneal size modify the distance between the paracentral lobule and bregma, and between the parietal lobe and lambda. Hence, the relative position of the cranial and cerebral landmarks can change as a function of the parietal dimensions. The slight correlation and covariation among these elements suggests a limited degree of spatial integration between soft and hard tissues. Therefore, although the brain influences the cranial size and shape during morphogenesis, the specific position of the cerebral components is sensitive to multiple effects and local factors, without a strict correspondence with the bone landmarks. This absence of correspondent change between brain and skull boundaries suggests caution when making inferences about the brain areas from the position of the cranial sutures. The fact that spatial relationships between cranial and brain areas may vary according to brain proportions must be considered in paleoneurology, when brain anatomy is inferred from cranial evidence.

Gender-based differences in the shape of the human corpus callosum are associated with allometric variations

The corpus callosum displays considerable morphological variability between individuals. Although some characteristics are thought to differ between male and female brains, there is no agreement regarding the source of this variation. Biomedical imaging and geometric morphometrics have provided tools to investigate shape and size variation in terms of integration and correlation. Here we analyze variations at the midsagittal outline of the corpus callosum in a sample of 102 young adults in order to describe and quantify the pattern of covariation associated with its morphology. Our results suggest that the shape of the corpus callosum is characterized by low levels of morphological integration, which explains the large variability. In larger brains, a minor allometric component involves a relative reduction of the splenium. Small differences between males and?females are associated with this allometric pattern, induced primarily by size variation rather than gender‐specific characteristics.

Correlation between corpus callosum shape and cognitive performance in healthy young adults

Corpus callosum (CC) might be related to cognitive performance because of its role in interhemispheric communication. Previous research has focused mainly on volumetric analyses of the CC, yielding contradictory results to some extent. Shape is an approach that integrates and extends the data obtained with the volumetric methodology. Here, we analyze the relationships between midsagittal CC shape variation and several cognitive measures. 2D coordinates from 102 MRI-scanned young adult human CCs were superimposed through a Procrustes approach. The residual variation was regressed onto 21 cognitive measures completed by the participants. Most of these measures (including general intelligence, working memory, executive functioning, and mental speed) were unrelated to midsagittal CC morphology. However, attentional control did show consistent and significant correlations with CC shape variation. Slower responses in attentional control were systematically associated with more curved and thinner CC, with consequent rotation of the splenium and the genu. Although the magnitude of the correlations suggests a small relationship of midsagittal CC geometry and attention, the results provide interesting clues regarding the links between brain anatomical configuration and human cognitive function.

Quantifying Patterns of Endocranial Heat Distribution: Brain Geometry and Thermoregulation

The mechanisms involved in brain thermoregulation are still poorly known, and many disagreements still exist concerning the selective cooling capacity of the brain volume. This issue has also been discussed in human evolution and paleoneurology, speculating on possible changes associated with hominid encephalization. Although the vascular system is supposed to be the main component responsible for thermoregulation, brain geometry also plays an important role in the pattern of heat distribution.

Diploic vessels and computed tomography: Segmentation and comparison in modern humans and fossil hominids

OBJECTIVES The diploic channels appear to be more developed in humans than in nonhuman primates, suggesting they may be relevant in evolutionary biology. This study is aimed at providing a segmentation procedure for diploic channels and CT analysis, a quantitative description of their variation in modern humans, and paleoanthropological case-studies. MATERIALS AND METHODS CT data were used for the 2D and 3D visualization, rendering, and measure, of diploic channels in modern and fossil hominids. We analyzed 20 modern human skulls and three Neanderthals. The effect of different resolution factors was evaluated. A specific protocol was designed to segment the vascular network and localize the main branches, reducing the noise of the cancellous bone. RESULTS We provide a quantitative description of the frontal, parietal, and occipital diploic networks in modern humans and in three Neanderthals. There is a correlation in the degree of vascularization among the different vault areas. No side differences can be detected. The diploic network is commonly connected with the meningeal artery at the temporal fossa, with the emissary veins at the occipital bone, and with the venous sinuses at the parieto-occipital areas. The channels are more developed in the parietal areas. The three Neanderthals show a vascular development, which is in the lower range of the modern human variation. CONCLUSIONS Modern humans display a large variation in their morphological patterns, being the parietal area the most vascularized. The pattern of the diploic channels may be relevant in anthropology, medicine, and paleontology, taking into account their possible involvement in thermoregulation.

A Digital Collection of Hominoid Endocasts

The major focus of this book is to provide the researcher or student with a general overview of the recent advances and updated knowledge regarding human paleoneurological research. In this context, the objective of this chapter is to provide the reader with a series of plates showing endocranial casts of several well-preserved and relevant fossil specimens representing different extinct hominid species, as well as some examples from living modern humans and great apes. Each plate depicts the external aspect of the cranium and its spatial relationship with the endocranial cavity in lateral norm, as well as a general view of each endocast viewed from all six norms. Additionally, some basic taxonomic notes collected from the literature are also provided (Groves 2001; Holloway et al. 2004; Isler et al. 2008; Wood and Lonergan 2008). With this material in hand, the reader may look at the evolutionary changes discussed in the present book regarding the evolution of the human endocranium and brain. It is worth noting that this chapter is not intended to give a detailed description of any particular specimen. For that purpose, we recommend to consult Holloway et al. (2004) extensive monograph on hominid endocasts. All specimens depicted here were digitally reconstructed from computed tomographic (CT) sections following the principles of digital anatomy (Zollikofer and Ponce de Leon 2005; Weber and Bookstein 2011). Missing parts of fossil crania where estimated using sliding semi-landmarks and thin-plate spline techniques as proposed elsewhere (Gunz et al. 2005, 2009). The only exception to this procedure is the Asian Homo erectus specimen Zhoukoudian XII, which consisted of surface scans of a reproduction of the original endocast made by Weindereich (1943) as well as a cast of the cranial reconstruction made by Tattersall and Sawyer (1996).