José Manuel Sabucedo Cameselle

Legitimación de la violencia y contexto: análisis textual del discurso de las FARC-EP

Resumen En este estudio se analizó el discurso de las FARC-EP durante un periodo de cinco años. Los resultados muestran la existencia de dos momentos discursivos claramente diferenciados que se asocian a las modificaciones producidas en el contexto político, especialmente en las relaciones entre ese grupo y el gobierno colombiano. Pero los datos de este trabajo revelan que esos cambios en el discurso son meramente estratégicos ya que en ambos periodos están presentes, aunque bajo fórmulas retóricas distintas, los argumentos que legitiman la existencia de ese grupo armado.

TERTp mutation is associated with a shorter progression free survival in patients with aggressive histology subtypes of follicular-cell derived thyroid carcinoma

PurposeEvaluate the impact of TERTp mutation on the outcomes after initial treatment of 45 patients with thyroid carcinomas derived from follicular cells (TCDFC) with aggressive histology, in which the role of this mutation is not yet well defined.MethodsAnalysis of the presence of TERTp (−124C > T and −146C > T), BRAF (V600E), and NRAS (Q 61R) mutations by Sanger sequencing and analysis of their correlation with the patient’s outcomes.ResultsForty-five patients with aggressive histopathologic variants were included in the study. Of these, 68.9% had aggressive variants of papillary thyroid cancer (PTC), 22.2% had poorly differentiated thyroid carcinoma (PDTC)/insular carcinoma, and 8.9% had invasive follicular thyroid cancer (FTC) with Hurthle cell features (Hurthle cell carcinoma). Lymph node metastases were present in 46.7% and distant metastases in 54.6%. The response to the initial therapy was excellent in 45.5% and structurally incomplete in 50%. During the follow-up period (median of 56 months; 5–360 months), 47.7% presented with disease progression and 17.8% experienced disease-related death. In 53.3% of the cases at least one molecular alteration (TERTp in 33.4%, BRAF in 24.5%, RAS in 8.9%) was detected. In the multivariate analysis, TERTp mutation was the factor associated with the highest risk (6 times) of having structural disease after initial therapy (p = 0.01), followed by vascular invasion (p = 0.02), gross extrathyroidal extension (ETE) (p = 0.02) and distant metastasis (p = 0.04). Regarding mutational status, only TERTp mutation was associated with disease progression, and diminished disease progression-free survival (PFS). The presence of distant metastasis, vascular invasion and gross ETE were significantly associated with the risk of disease progression.ConclusionsTERTp mutation appears be an indicator of both persistence and progression of structural disease after initial therapy in aggressive variants of TCDFC, and associates with a shorter progression free survival regardless of the therapy employed.

La percepción de la conducta agresiva: Un estudio taxonómico de las diferencias inter e intraculturales

This study empirically attempts to offer contributions for the classification of aggressive episodes. The proximity data approach is followed. Under this perspective, aggressive episodes are mapped as points in a n-dimensional space. Data were collected for two different spanish subcultures: undergraduates and prisoners. An individual differences multidimensional escaling model and method (Carroll and Chang, 1970) was used co analyze the data. The four-dimensional solution was retained. Differences between subcultures are found.