José María González-Pérez
Hospital Universitario de Canarias
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Featured researches published by José María González-Pérez.
Alcohol and Alcoholism | 2012
Emilio González-Reimers; F. Santolaria-Fernández; J.A. Medina-García; José María González-Pérez; M.J. de la Vega-Prieto; L. Medina-Vega; Candelaria Martín-González; M.C. Durán-Castellón
UNLABELLED In alcoholics, the activation of Kupffer cells by gram negative bacteriae leads to an inflammatory response and cytokine secretion, which in turn activate T-lymphocytes. Possibly, Th-1 lymphocytes are activated first, followed by a Th-2 response. Th-2 cytokines, especially interleukin (IL)-13 (scarcely studied in alcoholics), may be involved in the progression to chronic stages. AIMS The aim of the study was to analyze the relationship of Th-1 and Th-2 cytokines with liver function, alcohol consumption, nutritional status and survival. METHODS Serum Th-1 [interferon-γ (IFN-γ)] and Th-2 cytokines (IL-4, IL-13), IL-10, IL-6 and tumor necrosis factor (TNF-α), were determined for 18 controls and 47 stable alcoholics with variable liver function impairment, who were followed-up during a median time of 90 months, a period during which 14 patients died. RESULTS IL-4 was lower among patients; no differences were observed regarding IL-6, but the remaining ILs were higher among alcoholics. IL-10 and IL-13 were even higher in cirrhotics (Z = 2.88, P = 0.004, and Z = 2.09, P = 0.037, respectively). A significant, direct, correlation was observed between IL-13 and IL-10 (ρ = 0.49, P = 0.001), and non-significant, inverse ones were observed between IFN-γ and IL-13 (ρ = -0.23), IL-4 (ρ = -0.14) and IL-10 (ρ = -0.09). IL-13 and IL-10 were inversely related with liver function and, directly with immunoglobulin A levels, but not with survival. CONCLUSION Serum IFN-γ values were increased in alcoholics, who also showed raised IL-13 and IL-10, but lower IL-4 levels. Given the immunomodulatory roles of IL-10 and IL-13, this increase may be interpreted as a compensatory rise of anti-inflammatory cytokines. We failed to find any relation with mortality.
Biological Trace Element Research | 2012
José María González-Pérez; Emilio González-Reimers; María José DeLaVega-Prieto; M.C. Durán-Castellón; J. Viña-Rodríguez; L. Galindo-Martín; Julio Alvisa-Negrín; Francisco Santolaria-Fernández
Both manganese and copper may affect bone synthesis. Bone content of both metals can be altered in alcoholics, although controversy exists regarding this matter. To analyse the relative and combined effects of ethanol and a low protein diet on bone copper and manganese, and their relationships with bone structure and metabolism, including trabecular bone mass (TBM), osteoid area (OA), osteocalcin (OCN), insulin-like growth factor-1 (IGF-1), parathyroid hormone (PTH), urinary hydroxyproline (uHP) and vitamin D. Adult male Sprague–Dawley rats were divided into four groups. The control rats received a 18% protein-containing diet; a second group, an isocaloric, 2% protein-containing diet; a third one, an isocaloric, 36% ethanol-containing diet and a fourth, an isocaloric diet containing 2% protein and 36% ethanol. After sacrifice, TBM and OA were histomorphometrically assessed; bone and serum manganese and copper were determined by atomic absorption spectrophotometry, and serum OCN, IGF-1, PTH, uHP and vitamin D by radioimmunoassay. Ethanol-fed rats showed decreased TBM and bone manganese. Significant relationships existed between bone manganese and TBM, serum IGF-1 and OCN. Ethanol leads to a decrease in bone manganese, related to decreased bone mass and bone synthesis. No alterations were found in bone copper.
Journal of Trace Elements in Medicine and Biology | 2011
José María González-Pérez; Emilio González-Reimers; M.C. Durán-Castellón; Franscisco Santolaria-Fernández; L. Galindo-Martín; Rosa RosVilamajó; María José de la Vega-Prieto; J. Viña-Rodríguez; Pedro Abreu-Gonzalez
UNLABELLED Some observations suggest that oxidative damage may affect both osteoblastic function and osteoclastic activity in alcohol-mediated bone alterations. Selenium, a potent antioxidant, is decreased in alcoholics. OBJECTIVE To analyse if the supplementation with selenium may alter bone changes observed in a murine model fed ethanol and/or a 2% protein-containing diet, following the Lieber-deCarli design. MATERIAL AND METHOD Adult male Sprague-Dawley rats were divided into 8 groups, which received the Lieber-DeCarli control diet, an isocaloric, 36% ethanol-containing diet, an isocaloric, 2% protein-containing diet; and an isocaloric diet containing 2% protein and 36% ethanol diet, and another similar four groups to which selenomethionine (1mg/kg body weight). After sacrifice (5 weeks later), trabecular bone mass was histomorphometrically assessed, bone and serum selenium were determined by flame atomic absorption spectrophotometry, and serum osteocalcin, insulin growth factor 1 (IGF-1), PTH and telopeptide, by radioimmunoanalysis. Liver glutathione peroxidase (GPX) activity was also determined. RESULTS Ethanol-fed rats showed decreased TBM, IGF-1 and osteocalcin, especially when ethanol was added to a 2%-protein diet. Selenium did not modify at all bone parameters, despite a marked increase in serum selenium and a less pronounced one in bone selenium, and an increase in liver GPX. CONCLUSION Our results do not support the existence of a beneficial effect of selenium addition on bone changes observed in this murine model treated following the Lieber-deCarli experimental design.
Biological Trace Element Research | 2008
Emilio González-Reimers; L. Galindo-Martín; Francisco Santolaria-Fernández; María José Sánchez-Pérez; Julio Alvisa-Negrín; Elena García-Valdecasas-Campelo; José María González-Pérez; M. Candelaria Martín-González
Trace Elements and Electrolytes | 2008
Emilio González-Reimers; M.C. Martín-González; L. Galindo-Martín; M.C. Durán-Castellón; M.R. Aleman-Valls; J. Velasco-Vázquez; José María González-Pérez; F. Barroso-Guerrero
Biological Trace Element Research | 2014
María José Monedero-Prieto; José María González-Pérez; Emilio González-Reimers; Onán Hernández-Pérez; María Monereo-Muñoz; L. Galindo-Martín; Geraldine Quintero-Platt; Pedro Abreu-Gonzalez
Trace Elements and Electrolytes | 2014
Emilio González-Reimers; Candelaria Martín-González; L. Galindo-Martín; Remedius Aleman-Valls; José María González-Pérez; Carlos Jorge-Ripper; Oswaldo Elvira-Cabrera; Geraldine Quintero-Platt
Biological Trace Element Research | 2013
Emilio González-Reimers; M. J. Monedero-Prieto; José María González-Pérez; M.C. Durán-Castellón; L. Galindo-Martín; Pedro Abreu-Gonzalez; María José Sánchez-Pérez; Francisco Santolaria-Fernández
Journal of the American Geriatrics Society | 2016
Onán Pérez-Hernández; José María González-Pérez; Antonio Martínez-Riera; M.C. Durán-Castellón; María Monereo-Muñoz; Candelaria Martín-González; Francisco Santolaria-Fernández
Archive | 2014
Emilio González-Reimers; M. Arnay-de-la-Rosa; Aioze Trujillo; Manuel Machado-Calvo; Alejandra C. Ordóñez; Diego M. Pérez; José María González-Pérez; Agustín Castañeyra-Perdomo