José Nunes da Silva Júnior
Federal University of Ceará
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Publication
Featured researches published by José Nunes da Silva Júnior.
Journal of the Brazilian Chemical Society | 2015
Daniely H. P. Vasconcelos; Jair Mafezoli; Paula Karina S. Uchoa; Natália N. Saraiva; Mary Anne S. Lima; José Nunes da Silva Júnior; Francisco Geraldo Barbosa; Marcos Carlos de Mattos; Maria da Conceição F. de Oliveira; Cristiano Souza Lima; Maria Nenmaura Gomes Pessoa
The diterpene ent-18,19-dihydroxytrachylobane was biotransformed for the first time by Rhizopus stolonifer, and yielded the new ent-11β,18,19-trihydroxytrachylobane derivative besides the new ent-kaur-11-ene diterpenes ent-16α,18,19-trihydroxykaur-11-ene and ent-18,19-dihydroxy-16α-methoxykaur-11-ene. Their structures were determined by spectrometric methods.
Journal of the Brazilian Chemical Society | 2015
Sousa Ah; José Nunes da Silva Júnior; Maria Lenise Silva Guedes; Raimundo Braz-Filho; Letícia V. Costa-Lotufo; Ana Jérsia Araújo; Edilberto R. Silveira; Mary Anne S. Lima
An asymmetrical dimer of kaurane diterpene and monoterpene and four novel diterpenes were isolated from the roots of Croton limae, along with kaempferol-3-O-glucoside, ombuin- 3-O-rutinoside and acetyl aleuritolic acid. The cytotoxic activity of the kaurane diterpene was evaluated against colorectal adenocarcinoma (HCT-116), ovarian carcinoma (OVCAR-8) and glioma (SF-295) cell lines, exhibiting IC50 values of 7.14, 8.19 and > 10 µg mL−1, respectively.
Química Nova | 2014
José Nunes da Silva Júnior; Francisco Geraldo Barbosa; Antonio José Melo Leite Junior; Valeska Mesquita Eduardo
that shows how electrons are shared between two or more atoms and allows a prediction of the chemical reactivity and relative stability of reagents, intermediates, and products. An educational software that enables interactive exploration of the concepts related to resonance and thereby facilitates its understanding was developed. The software was field-tested, and an evaluation questionnaire concerning the software as an educational tool was answered by the students and professors involved in the test. The results led to the conclusion that the developed computer application can be characterized as an auxiliary tool that assists teachers in their lectures and students in their learning process.
Química Nova | 2012
José Nunes da Silva Júnior; Francisco Geraldo Barbosa; Antonio José Melo Leite Junior
Optical activity is the ability of chiral substances to rotate the plane of plane-polarized light and is measured using an instrument called a polarimeter. An educational software application to explore, both interactively and visually, the concepts related to polarimetry to facilitate their understanding was developed. The software was field-tested and a questionnaire evaluating the graphics interface, usability and the software as an educational tool, was answered by students. The results characterized the computer application developed as an auxiliary tool for assisting teachers in lectures and students in the learning process.
Química Nova | 2015
Francisco Geraldo Barbosa; Jair Mafezoli; Mary Anne S. Lima; Francisco Serra Oliveira Alexandre; Diego Macedo de Almeida; Antonio José Melo Leite Junior; José Nunes da Silva Júnior
Intermolecular forces are a useful concept that can explain the attraction between particulate matter as well as numerous phenomena in our lives such as viscosity, solubility, drug interactions, and dyeing of fibers. However, studies show that students have difficulty understanding this important concept, which has led us to develop a free educational software in English and Portuguese. The software can be used interactively by teachers and students, thus facilitating better understanding. Professors and students, both graduate and undergraduate, were questioned about the software quality and its intuitiveness of use, facility of navigation, and pedagogical application using a Likert scale. The results led to the conclusion that the developed computer application can be characterized as an auxiliary tool to assist teachers in their lectures and students in their learning process of intermolecular forces.
Helvetica Chimica Acta | 2013
Francisco Artur e Silva Filho; José Nunes da Silva Júnior; Raimundo Braz-Filho; Carlos A. de Simone; Edilberto R. Silveira; Mary Anne S. Lima
Journal of Chemical Education | 2014
José Nunes da Silva Júnior; Mary Anne S. Lima; Eduardo Henrique Silva Sousa; Francisco Serra Oliveira Alexandre; Antonio José Melo Leite Junior
Journal of Chemical Education | 2017
José Nunes da Silva Júnior; Mary Anne S. Lima; João Victor Xerez Moreira; Francisco Serra Oliveira Alexandre; Diego Macedo de Almeida; Maria da Conceição F. de Oliveira; Antonio José Melo Leite Junior
Natural Product Communications | 2014
Mafezoli J; Oliveira Mc; Paiva; Sousa Ah; Lima Ma; José Nunes da Silva Júnior; Francisco Geraldo Barbosa; Wijeratne Em; Gunatilaka Aa
Journal of the Brazilian Chemical Society | 2012
Pérsio Alexandrino Veloso; Antonia T. A. Pimenta; Sousa Francisco M. de; Maria José C. Falcão; Nilce V. Gramosa; José Nunes da Silva Júnior; Edilberto R. Silveira; Mary Anne S. Lima