Josep M. Castello

New imidazole antifungal agents derived from benzo[b]thiophene

Abstract 1-[(Aryl)(benzo[ b ]thienyl)methyl]-1 H -imidazoles 22 , 1-[(benzo[ b ]thien-3-yl)(thienyl)methyl]-1 H -imidazoles 25 and 1-[(diaryl)(benzo[ b ]thien-3-yl)methyl]-1 H -imidazoles 28 have been synthesized and tested for anti-fungal activity. All compounds showed good activity against a broad spectrum of fungi (yeasts, dermatophytes).

Preparation, antimicrobial evaluation, and mutagenicity of [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols, [5-tert-Butyl-2-methylaminophenyl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanol, and [2-Hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl] ketones

Efficient preparations of the titled compounds are described, their antimicrobial activity and mutagenic properties being evaluated. Some of the studied compounds are nonmutagenic and present a MIC as low as some of the usual standards in the field.

Preparation, antimicrobial evaluation and mutagenicity of differently substituted [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols

Abstract An efficient preparation of the titled compounds is described, their antimicrobial activity and mutagenic properties being evaluated. Some of the studied compounds are non mutagenic and present a MIC as low as some of the usual standards in the field.