Joseph H. Perlmutt

Effect of Intravenous Injections of Desoxycorticosterone Glucoside upon Blood Glucose of Adrenalectomized Dogs.

Summary and Conclusion (A) Three types of fasted adrenalectomized dogs were studied: (1) those maintained in normal health; (2) those exhibiting mild insufficiency symptoms; and (3) animals in severe adrenal crisis. When these dogs were injected intravenously with massive doses of DCG, only occasional blood glucose changes were observed. These infrequent rises in glucose were associated with marked improvement in the circulation of the animal, increased hydration, increased vigor and muscular activity. (B) A fasted, intact dog, injected with 300 mg DCG, did not show any significant changes in blood sugar level over a 24-hour period

Contralateral renal function after unilateral renal vein ligation.

The effect of increased pressure in one kidney, produced by ligation of its vein, on contralateral renal function was investigated in eight anesthetized dogs. Kidney function was determined under t...